Brief debrisoquin administration to assess central dopaminergic function in children.

Abstract:

:Central dopaminergic (DA) function in children was assessed by monitoring plasma-free homovanillic acid (pHVA) levels after brief (18 hour) administration with debrisoquin sulfate, a peripherally active antihypertensive agent that blocks peripheral, but not central, HVA production. Brief debrisoquin administration resulted in marked reductions in pHVA in each of six patients studied. In five of the six patients, post-debrisoquin pHVA levels remained relatively stable over the six-hour period of observation. No significant cardiovascular or behavioral side effects of debrisoquin were observed. The brief debrisoquin administration method appears to be a safe, simple, and potentially valid peripheral technique for evaluating aspects of central dopaminergic function in children with neuropsychiatric disorders. Additional work is needed to further establish this method's validity and reliability.

journal_name

Life Sci

journal_title

Life sciences

authors

Riddle MA,Shaywitz BA,Leckman JF,Anderson GM,Shaywitz SE,Hardin MT,Ort SI,Cohen DJ

doi

10.1016/0024-3205(86)90239-0

subject

Has Abstract

pub_date

1986-03-17 00:00:00

pages

1041-8

issue

11

eissn

0024-3205

issn

1879-0631

pii

0024-3205(86)90239-0

journal_volume

38

pub_type

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