Influence of adrenal cortex on testicular activity in the toad during the breeding season.

abstract：:N-acyl dehydroalanines have been shown to react with and scavenge oxygen derived free radicals. One of those compounds, the AD-5 (N-(paramethoxyphenylacetyl) dehydroalanine) has been examined for its ability to decrease the amount of reactive oxygen species which appeared when liver microsomes (isolated from rats pret...

journal_title：Life sciences

authors： Buc-Calderon P,Roberfroid M

更新日期：1990-01-01 00:00:00

abstract：:The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed for the different ag...

journal_title：Life sciences

authors： Henry JM,Roth GS

更新日期：1984-08-20 00:00:00

abstract：:5-hydroxytryptamine (5-HT) caused concentration-dependent relaxation of isolated rings from porcine vena cava contracted with alpha-methyl 5-HT or prostaglandin F2 alpha. Relaxation was not blocked by propranolol (1 micron), atropine (1 micron), indomethacin (3 microns), mepyramine (1 micron), cimetidine (1 micron), o...

journal_title：Life sciences

authors： Trevethick MA,Feniuk W,Humphrey PP

更新日期：1984-07-30 00:00:00

abstract：:The effects of elevated glucose and aldose reductase inhibitor (ARI:ONO-2235) on nitric oxide (NO) production in cultured human umbilical endothelial cells (HUVEC) were evaluated. Aldose reductase and nitric oxide synthase(NOS) share NADPH as an obligate cofactor, therefore it is suggested that the enhanced of glucose...

journal_title：Life sciences

authors： Okuda Y,Kawashima K,Suzuki S,Asakura Y,Asano M,Tsurumaru K,Dai H,Tachi Y,Bannai C,Saitoh M,Yamashita K

更新日期：1997-01-01 00:00:00

abstract：:Decidualization of endometrial tissues, which is essential for implantation and the continuation of pregnancy, is induced by pituitary hormones that are regulated by gonadotropin releasing hormone (GnRH). Our objective was to determine the role of a direct action of GnRH on endometrial tissues by comparing the charact...

journal_title：Life sciences

authors： Takeuchi S,Futamura N,Minoura H,Toyoda N

更新日期：1998-01-01 00:00:00

abstract：:The injection of neostigmine into the hippocampus of anesthetized rats increased the mean arterial blood pressure (17% of baseline after 60 min injection) and decreased the heart rate (24% of baseline after 60 min injection). These changes were blocked by the co-administration of methylatropine into the hippocampus. I...

journal_title：Life sciences

authors： Haruta K,Iguchi A,Matsubara T,Itoh K,Chen CL,Yoshida S,Terada R,Kanashiro M,Suzuki O,Nishimura H

更新日期：1992-01-01 00:00:00

abstract：:The analgesic effects of bestatin and thiorphan, two enzymatic inhibitors protecting endogenous enkephalins from their degradation, and those of DAGO and deltakephalin, respectively mu and delta opioid peptides, are assessed on the electrical stimulation test of the mouse tail. The relative analgesic potency of DAGO a...

journal_title：Life sciences

authors： Chaillet P,Coulaud A,Fournié-Zaluski MC,Gacel G,Roques BP,Costentin J

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are widely applied in various clinical disorders, including acute lung injury (ALI). We aimed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs)-derived exosomal microRNA-22-3p (miR-22-3p) on lipopolysaccharid (LPS)-induced ALI via...

journal_title：Life sciences

authors： Zheng Y,Liu J,Chen P,Lin L,Luo Y,Ma X,Lin J,Shen Y,Zhang L

更新日期：2021-01-06 00:00:00

abstract：:CYP3A4, the predominant cytochrome P450 (CYP) expressed in human liver, contributes to the metabolism of approximately half the drugs in use today. In general, human-derived cell lines fail to express CYPs. It was previously shown that CYP3A4 mRNA and CYP3A immunoreactive protein are induced by 1alpha,25-dyhydroxyvita...

journal_title：Life sciences

authors： Elizondo G,Medina-Díaz IM

更新日期：2003-05-30 00:00:00

abstract：:The study of opioid distribution in blood and cerebrospinal fluid (CSF) is required to understand pharmacokinetic-pharmacodynamic relationships following lumbar intrathecal (it) and intracerebroventicular (i.c.v.) administration, and to investigate the contributions of spinal or supraspinal sites of action. The sheep ...

journal_title：Life sciences

authors： Payne R,Gradert TL,Inturrisi CE

更新日期：1996-01-01 00:00:00

abstract：AIMS:Dietary habits are crucial factors affecting metabolic homeostasis. However, few animal experiments have addressed the effects of long-term feeding with soft food on parameters reflecting systemic health. MAIN METHODS:Using mice, we compared the effects of short (3 days) and long (17 weeks from weaning) feeding p...

journal_title：Life sciences

authors： Tsuchiya M,Niijima-Yaoita F,Yoneda H,Chiba K,Tsuchiya S,Hagiwara Y,Sasaki K,Sugawara S,Endo Y,Tan-No K,Watanabe M

更新日期：2014-05-08 00:00:00

abstract：:The O2 affinity of "stripped" (cofactor-free) hemoglobin (Hb) of the elasmobranch, Squalus acanthias is decreased by ATP, the main erythrocytic phosphate cofactor but increased by urea at physiological concentration. When both compounds are present, as in life, urea decreases the ATP sensitivity, indicating that previ...

journal_title：Life sciences

authors： Weber RE,Wells RM,Tougaard S

更新日期：1983-05-02 00:00:00

abstract：:A mechanism of antidepressant activity of beta-amyrin palmitate was studied using the forced swimming method in mice. Beta-amyrin palmitate (10 mg/kg) reduced the increase in the duration of immobility induced by tetrabenazine (100 and 200 mg/kg), but showed no effect on that in mice treated with alpha-methyl-para-tyr...

journal_title：Life sciences

authors： Subarnas A,Tadano T,Nakahata N,Arai Y,Kinemuchi H,Oshima Y,Kisara K,Ohizumi Y

更新日期：1993-01-01 00:00:00

abstract：AIMS AND METHODS:We previously reported that angiotensin II (AngII) restores the vascular reactivity diminished by hemorrhagic shock. In this study, we investigated whether the beneficial effects of AngII are related to regulation of gap junctions (GJs) and connexin43 (Cx43), and the implication of MAPK signaling and m...

journal_title：Life sciences

authors： Lei Y,Peng X,Li T,Liu L,Yang G

更新日期：2019-01-01 00:00:00

abstract：:Quinolinic acid (QUIN) levels are elevated in patients and animals suffering from chronic infectious diseases. In the present study, male Sprague-Dawley rats were used to test the anti-inflammatory effects of QUIN using the carrageenan (CGN)-induced paw edema assay and the CGN sponge assay. Results of these studies in...

journal_title：Life sciences

authors： Heyliger SO,Mazzio EA,Soliman KF

更新日期：1999-01-01 00:00:00

abstract：:Using hot plate method, analgesia induced by noncatecholic phenylethylamines, phenethylamine, phenylethanolamine and amphetamine, was inhibited by naloxone, reserpine, apomorphine and p-chlorophenylalanine, while potentiated by haloperidol. These results suggest that phenylethylamines induced analgesia involves centra...

journal_title：Life sciences

authors： Kubota K,Matsuoka Y,Sakuma M,Satoh S,Uruno T,Sunagane N

更新日期：1982-09-20 00:00:00

abstract：:L-dopa is the major treatment for Parkinson's disease (PD), but its efficacy is limited by the presence of dyskinesia. The dyskinesia develops over a period of exposure to L-dopa and is related to the dosage, therefore, the cause may involve inductive changes that produce toxic levels of metabolites, interfering with ...

journal_title：Life sciences

authors： Charlton CG,Crowell B Jr

更新日期：2000-04-21 00:00:00

abstract：:The aims of the current study were: 1) to determine if the epsilonPKC pseudosubstrate peptide (epsilonphi) (NH(2)-RKRQGAVRRRVHQVNG-COOH) could be used as an epsilonPKC-selective inhibitor in neonatal cardiac myocytes (NCMs) and 2) to determine if differences in the alpha and epsilonPKC autoinhibitory pseudosubstrate m...

journal_title：Life sciences

authors： Johnson JA

更新日期：2004-05-07 00:00:00

abstract：:We investigated the combined effect of 5-hydroxytryptamine (5-HT, serotonin) and calcium ionophore (A23187) on human platelet aggregation. Aggregation, monitored at 37 degrees C using a Dual-channel Lumi-aggregometer, was recorded for 5 min after challenge by a change in light transmission as a function of time. 5-HT ...

journal_title：Life sciences

authors： Connor JD,Rasheed H,Gilani AH,Cheema M,Rizvi Z,Saeed SA

更新日期：2001-10-26 00:00:00

abstract：AIMS:High level of saturated fatty acids leads to mitochondrial dysfunction and inflammation in the development of insulin resistance in skeletal muscle. We recently found that puerarin improved impaired insulin signaling in skeletal muscle in diabetic animals and in myotubes in vitro. However, whether puerarin can act...

journal_title：Life sciences

authors： Chen X,Yi L,Song S,Wang L,Liang Q,Wang Y,Wu Y,Gao Q

更新日期：2018-08-01 00:00:00

abstract：:The effect of gonadal steroids on the response to analgesia testing was determined in castrated male and female rats and castrated male and female rats treated with testosterone propionate (TP) and estradiol benzoate (EB), respectively. The time to respond to a noxious somatic stimulus in the form of heat was assessed...

journal_title：Life sciences

authors： Forman LJ,Tingle V,Estilow S,Cater J

更新日期：1989-01-01 00:00:00

abstract：:The effect of several anti-inflammatory drugs (NSAIDs), the calmodulin inhibitor W-7 and cortisol on vanadate-induced tonic contraction and on calmodulin dependent cAMP-phosphodiesterase activity have been assayed. Indomethacin, diclofenac, phenylbutazone, mefenamic acid, naproxen, tolmetin, piroxicam, aspirin and W-7...

journal_title：Life sciences

authors： Cantabrana B,Perez Vallina JR,Menéndez L,Hidalgo A

更新日期：1995-01-01 00:00:00

abstract：:Fish oil is rich in the long chain n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); typically these fatty acids constitute 20 to 25 g/100 g total fatty acids in fish oil. Feeding rodents diets rich in fish oil has been shown to decrease lymphocyte proliferation and natural ki...

journal_title：Life sciences

authors： Peterson LD,Thies F,Sanderson P,Newsholme EA,Calder PC

更新日期：1998-01-01 00:00:00

abstract：AIMS:Hypoxia is implicated in the pathogenesis of rheumatoid arthritis (RA), contributing to the tumor-like phenotypes of RA fibroblast-like synoviocytes (RA-FLSs). Andrographolide is the main bioactive component of Andrographis paniculata, an herbal medicine that shows therapeutic benefits in RA patients. Here, we exp...

journal_title：Life sciences

authors： Li GF,Qin YH,Du PQ

更新日期：2015-09-01 00:00:00

abstract：:Arsenic as a one of the most important toxic metals could induce hepatotoxicity. Previous reports revealed the significance of oxidative stress in promoting of arsenic-induced liver toxicity. The aim of the present investigation is to evaluate the effect of chrysin (CHR), a natural flavonoid with potent antioxidant ac...

journal_title：Life sciences

authors： Fatemi I,Khalili H,Mehrzadi S,Basir Z,Malayeri A,Goudarzi M

更新日期：2021-02-15 00:00:00

abstract：:Convulsive seizures are a potential side effect of antidepressant drug treatment and can be produced by all classes of antidepressants. It is also known that some convulsant and anticonvulsant drug actions are mediated by the GABA-receptor chloride-ionophore complex. Drugs acting at this complex appear to induce convu...

journal_title：Life sciences

authors： Malatynska E,Knapp RJ,Ikeda M,Yamamura HI

更新日期：1988-01-01 00:00:00

abstract：:The Thirteenth International Conference on Endothelin (ET-13) was held from September 8-11, 2013 in Tokyo, Japan chaired by Noriaki Emoto, Kobe Pharmaceutical University, Japan, and Takashi Miyauchi, University of Tsukuba, Japan and held on the Tokyo Campus of Tsukuba University. The International Conferences on Endot...

journal_title：Life sciences

authors： Emoto N,Yanagisawa M

更新日期：2014-11-24 00:00:00

abstract：:Polyamines have been shown to relax several types of smooth muscle including vasculature. In the estrogen-treated uterus, uterine blood flow and polyamine levels in the uterus are increased. The relaxant effect of polyamines on blood vessels suggest that polyamines may act on uterine vasculature to cause uterine hyper...

journal_title：Life sciences

authors： Wing LY

更新日期：1992-01-01 00:00:00

abstract：:This study demonstrates the formation of gamma-glutamyl peptides from glutamine and plasma amino acids, as catalyzed by gamma-glutamyl transpeptidase. It also establishes the effect of various amino acids in modulating the rate of glutamine utilization as well as the hydrolytic or transfer product formed. The mechanis...

journal_title：Life sciences

authors： Dass PD

更新日期：1983-10-31 00:00:00

abstract：:Osteoarthritis (OA) is a complex joint disorder with a number of underlying physical, biochemical, biomechanical and genetic causes. Obesity is considered to be one of the major risk factors for the development and progression of OA. It actively contributes to the inflammatory status and to cartilage degradation in th...

journal_title：Life sciences

authors： Scotece M,Mobasheri A

更新日期：2015-11-01 00:00:00