Furowanin A-induced autophagy alleviates apoptosis and promotes cell cycle arrest via inactivation STAT3/Mcl-1 axis in colorectal cancer.

Abstract:

:Aim Furowanin A (Fur A) is a flavonoid isolated from Millettia pachycarpa Benth. Studies show its potent anti-neoplastic effects against leukemia cells. The aim of the present study was to determine the potential therapeutic effect of Fur A against colorectal cancer (CRC), and elucidate the underlying mechanism. MATERIAL AND METHODS:Cell Counting Kit-8 (CCK-8) assay was used to determine cell, and TUNEL and Annexin-V/PI staining was used to detect apoptosis and the cell cycle distribution. The expression levels of specific proteins in the CRC cells were analyzed by Western blotting. A xenograft model was also established to evaluate the therapeutic effect of Fur A in vivo. KEY FINDINGS:Fur A suppressed proliferation, blocked cell cycle progression, induced apoptosis and promoted autophagy in CRC cells. Interestingly, Fur A-induced autophagy functioned not only as a survival mechanism against apoptosis but also intensified the cell cycle arrest in CRC cells. In addition, Fur A mediated its effects via the inactivation of the STAT3/Mcl-1 axis. SIGNIFICANCE:Fur A is a promising drug candidate for the treatment and prevention of CRC.

journal_name

Life Sci

journal_title

Life sciences

authors

Ma Z,Bao X,Gu J

doi

10.1016/j.lfs.2018.12.027

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

47-57

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(18)30820-8

journal_volume

218

pub_type

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