Furowanin A-induced autophagy alleviates apoptosis and promotes cell cycle arrest via inactivation STAT3/Mcl-1 axis in colorectal cancer.


:Aim Furowanin A (Fur A) is a flavonoid isolated from Millettia pachycarpa Benth. Studies show its potent anti-neoplastic effects against leukemia cells. The aim of the present study was to determine the potential therapeutic effect of Fur A against colorectal cancer (CRC), and elucidate the underlying mechanism. MATERIAL AND METHODS:Cell Counting Kit-8 (CCK-8) assay was used to determine cell, and TUNEL and Annexin-V/PI staining was used to detect apoptosis and the cell cycle distribution. The expression levels of specific proteins in the CRC cells were analyzed by Western blotting. A xenograft model was also established to evaluate the therapeutic effect of Fur A in vivo. KEY FINDINGS:Fur A suppressed proliferation, blocked cell cycle progression, induced apoptosis and promoted autophagy in CRC cells. Interestingly, Fur A-induced autophagy functioned not only as a survival mechanism against apoptosis but also intensified the cell cycle arrest in CRC cells. In addition, Fur A mediated its effects via the inactivation of the STAT3/Mcl-1 axis. SIGNIFICANCE:Fur A is a promising drug candidate for the treatment and prevention of CRC.


Life Sci


Life sciences


Ma Z,Bao X,Gu J




Has Abstract


2019-02-01 00:00:00












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    abstract::SGK1 is one of the protein-serine/threonine kinases that is activated by insulin in a PI3K-dependent manner. Although SGK1 mediates a variety of biological activities, the mechanisms regulating its activity remain unclear. In this study, we examined the potential roles of calcium signaling in the activation of SGK1. T...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Imai S,Okayama N,Shimizu M,Itoh M

    更新日期:2003-04-04 00:00:00

  • Urantide attenuates myocardial damage in atherosclerotic rats by regulating the MAPK signalling pathway.

    abstract:OBJECTIVE:To explore the effect of urantide on atherosclerotic myocardial injury by antagonizing the urotensin II/urotensin II receptor (UII/UT) system and regulating the mitogen-activated protein kinase (MAPK) signalling pathway. METHODS:Atherosclerosis (AS) was established in rats by administering a high-fat diet an...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Zhao J,Miao G,Wang T,Li J,Xie L

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  • Role of acute elevation of portal venous pressure by exogenous glucagon on gastric mucosal injury in rats with portal hypertension.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Tsui CP,Sung JJ,Leung FW

    更新日期:2003-07-18 00:00:00

  • Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat.

    abstract::There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Jalil JE,Ebensperger R,Meléndez J,Acevedo E,Sapag-Hagar M,González-Jara F,Gálvez A,Pérez-Montes V,Lavandero S

    更新日期:1999-01-01 00:00:00

  • Brief debrisoquin administration to assess central dopaminergic function in children.

    abstract::Central dopaminergic (DA) function in children was assessed by monitoring plasma-free homovanillic acid (pHVA) levels after brief (18 hour) administration with debrisoquin sulfate, a peripherally active antihypertensive agent that blocks peripheral, but not central, HVA production. Brief debrisoquin administration res...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Riddle MA,Shaywitz BA,Leckman JF,Anderson GM,Shaywitz SE,Hardin MT,Ort SI,Cohen DJ

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  • The theaflavin fraction is responsible for the facilitatory effect of black tea at the skeletal myoneural junction.

    abstract::The effect of various fractions of black tea [(Camellia Sinensis) (L) O. Kuntze (Theaceae)] on the function of mammalian skeletomotor apparatus was studied. The theaflavin fraction (Tfs) produced a concentration- dependent facilitation of indirect twitch responses of the rat phrenic nerve diaphragm preparation and the...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Basu S,Chaudhuri T,Chauhan SP,Das Gupta AK,Chaudhury L,Vedasiromoni JR

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  • A convulsant, 3-mercaptopropionic acid, decreases the level of GABA in pancreatic islets of rat as well as that of brain.

    abstract::To investigate the properties of the gamma-aminobutyric acid (GABA) synthesizing enzyme, glutamate decarboxylase (GAD), in the brain and the pancreatic islets of the rat, GABA concentration in the brain and the pancreatic islets was measured after administration of 3-mercaptopropionic acid (3-MP) at 25 mg/kg intraperi...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Katoh J,Taniguchi H,Ogura M,Miyamoto K,Kasuga M,Okada Y

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  • Warburg Effect Inversion: Adiposity shifts central primary metabolism in MCF-7 breast cancer cells.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Luis C,Duarte F,Faria I,Jarak I,Oliveira PF,Alves MG,Soares R,Fernandes R

    更新日期:2019-04-15 00:00:00

  • Endogenous nitric oxide in expired air: effects of acute exercise in humans.

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    journal_title:Life sciences

    pub_type: 临床试验,杂志文章


    authors: Bauer JA,Wald JA,Doran S,Soda D

    更新日期:1994-01-01 00:00:00

  • FSH bioactivity is strongly enhanced by kinetic incubation of pre-antral hamster follicles.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Goverde HJ,van de Venne WP

    更新日期:1994-01-01 00:00:00

  • Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats.

    abstract::Coxsackievirus B3 (CVB3) is a major pathogen for acute and chronic viral myocarditis. The aim of this study was to investigate the antiviral effects of sophoridine, an alkaloid extracted from Chinese medicinal herb, Sophora flavescens, against CVB3, and the underlying pharmacokinetics. First, we determined the antivir...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Zhang Y,Zhu H,Ye G,Huang C,Yang Y,Chen R,Yu Y,Cui X

    更新日期:2006-03-20 00:00:00

  • Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo.

    abstract::We investigated the inhibition of human cholinesterases by galanthamine, an alkaloid of the common snowdrop (galanthus nivalis). In vitro, the compound showed potent enzyme inhibition and 50-fold selectivity for acetylcholinesterase (EC as opposed to butyrylcholinesterase (EC There was no difference...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Thomsen T,Kewitz H

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  • Excretion of urinary epidermal growth factor in non-insulin dependent diabetes mellitus.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Kawaguchi M,Kamiya Y,Ito J,Fujii T,Hayakawa F,Sakuma N,Fujinami T

    更新日期:1993-01-01 00:00:00

  • The neuronal transport mechanism for noradrenaline is not influenced by the ATP analogue ATP gamma S.

    abstract::Noradrenaline is taken up in noradrenergic neurones via a desipramine-sensitive transport system (uptake1). There are reports which describe the activity of uptake1 being increased by extracellular ATP and ATP gamma S. This was attributed to a protein kinase-mediated mechanism. We reevaluated this phenomenon since a m...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Gliese M,Babin-Ebell J,Schömig E,Russ H

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  • Alpha(1)-adrenergic receptor subtypes: non-identical triplets with different dancing partners?

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    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Hague C,Chen Z,Uberti M,Minneman KP

    更新日期:2003-12-12 00:00:00

  • Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Lemaire G,Mnif W,Mauvais P,Balaguer P,Rahmani R

    更新日期:2006-08-15 00:00:00

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Lichtstein D,Steinitz M,Gati I,Samuelov S,Deutsch J,Orly J

    更新日期:1998-01-01 00:00:00

  • Effects of ultraviolet radiation on the tension and the cyclic GMP level of bovine mesenteric arteries.

    abstract::Strips of bovine mesenteric arteries brought to sustained contraction by the addition of 3.0 microM phenylephrine relaxed when exposed to ultraviolet radiation (366 nm). The relaxation was reversible and associated with a rapid increase in the cGMP content. After termination of the radiation the cGMP level rapidly dec...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Karlsson JO,Axelsson KL,Andersson RG

    更新日期:1984-04-16 00:00:00

  • Icariin protects neurons from endoplasmic reticulum stress-induced apoptosis after OGD/R injury via suppressing IRE1α-XBP1 signaling pathway.

    abstract::Icariin (ICA), a flavonol glycoside isolated from Epimedium, has been considered as a potential alternative therapy for ischemic stroke. However, the protective mechanisms of ICA on cerebral ischemia-reperfusion (I/R) are not fully illuminated yet. The effects of ICA on ER stress and inflammatory response which were i...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Mo ZT,Liao YL,Zheng J,Li WN

    更新日期:2020-08-15 00:00:00

  • Absence of association of TAP and LMP genes with type 1 (insulin-dependent) diabetes mellitus.

    abstract::Although one of the major genes which cause type 1 (insulin-dependent) diabetes mellitus is located in the class II HLA region in humans, its precise location is still unknown. In order to investigate whether TAP (Transporter associated with Antigen Processing) and LMP (Low Molecular Weight Polypeptide) genes, which a...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Kawaguchi Y,Ikegami H,Fukuda M,Takekawa K,Fujioka Y,Fujisawa T,Ueda H,Ogihara T

    更新日期:1994-01-01 00:00:00

  • GABA as a trophic factor during development.

    abstract::The process of synaptogenesis has been studied by many investigators to determine the factors which regulate synapse formation. We have used neonatal rabbit retina to investigate the role of the gamma-aminobutyric acid (GABA) neurotransmitter system during development. By utilizing an in vitro incubation treatment of ...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Madtes P Jr,Redburn DA

    更新日期:1983-09-05 00:00:00

  • Intrahippocampal injection of TsTX-I, a beta-scorpion toxin, causes alterations in electroencephalographic recording and behavior in rats.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Teixeira VF,Conceição IM,Lebrun I,Nencioni AL,Coronado Dorce VA

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    abstract::Extracts of increasing polarity of 6 Venezuelan plants belonging to the Chrysobalanaceae family were tested for possible letal toxicity against Biomphalaria glabrata Say, a snail intermediate hosts of Schistosoma mansoni Sambon. The piscicidal toxicity of the active extracts was also evaluated with the aim of findings...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Bilia AR,Braca A,Mendez J,Morelli I

    更新日期:2000-01-01 00:00:00

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Gauquelin G,Schiffrin EL,Garcia R,Entresangles M,Cantin M,Gharib C

    更新日期:1988-01-01 00:00:00

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Karthikeyan K,Bai BR,Gauthaman K,Sathish KS,Devaraj SN

    更新日期:2003-10-10 00:00:00

  • Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Ueda Y,Miyagawa N,Wakitani K

    更新日期:2007-01-09 00:00:00

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Cardinot TM,Lima TM,Moretti AI,Koike MK,Nunes VS,Cazita PM,Krieger MH,Brum PC,Souza HP

    更新日期:2016-05-15 00:00:00

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Fonseca F,Ballerini AP,Izar MC,Kato J,Ferreira CE,Fonzar W,do Amaral J,Rezende P,Machado-Santelli G,França C

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Sun S,Yang F,Zhu Y,Zhang S

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Haigler HJ,Cahill LF,Crager MR,Charles E

    更新日期:1987-01-12 00:00:00