Abstract：
:Interleukin-1 (IL-1) is a monokine which has been demonstrated to produce a variety of seemingly diverse metabolic events including fever, neutrophilia, anorexia, altered mineral metabolism, muscle catabolism, and fibroblast proliferation. Because many of the clinical features of alcoholic hepatitis are metabolic abnormalities that have been shown to be caused by IL-1, we questioned whether patients with alcoholic hepatitis had elevated serum levels of IL-1. Six patients with alcoholic hepatitis had serum IL-1 activity measured by the thymocyte costimulator assay after serum inhibitors were removed. Their values were compared to those of 6 age and sex-matched healthy controls. Patients with alcoholic hepatitis had markedly elevated serum IL-1 activity, with the integrated value of all fractions having serum IL-1 activity being 9.8 times that of controls. IL-1 activity in serum from alcoholic hepatitis patients also was blocked by antibody to IL-1. We conclude that patients with alcoholic hepatitis have increased serum IL-1 activity which may play a role in certain of the metabolic complications of alcoholic hepatitis.
journal_name
Life Scijournal_title
Life sciencesauthors
McClain CJ,Cohen DA,Dinarello CA,Cannon JG,Shedlofsky SI,Kaplan AMdoi
10.1016/0024-3205(86)90554-0subject
Has Abstractpub_date
1986-10-20 00:00:00pages
1479-85issue
16eissn
0024-3205issn
1879-0631pii
0024-3205(86)90554-0journal_volume
39pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Oxytocin (OT) and arginine-8-vasopressin (AVP) were measured by radioimmunoassay in micropunched hypothalamic neurosecretory nuclei of estrous cycling female Sprague-Dawley rats. In the paraventricular nucleus (PVN): the concentration (pg/microgram protein) of OT was significantly higher in rats in diestrus than durin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90638-7
更新日期：1986-06-23 00:00:00
abstract：:Transcription factor Gata3 is implicated in the formation of autosomal dominant hypoparathyroidism, sensorineural deafness, and renal anomaly (HDR) syndrome. We pursued to identify the potential Gata3 target genes by profiling the gene expression pattern in E9.5 Gata3-/- mouse embryos. Altogether four independent micr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.054
更新日期：2005-04-15 00:00:00
abstract：:S-adenosylmethionine and adenosine levels in the rat pineal gland were determined by high-performance liquid chromatography after fractionation of the pineal extracts. The concentration of S-adenosylmethionine follows a circadian rhythm and is about three times higher during the day (2.5 nmol/gland) than the night (1....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90253-4
更新日期：1984-08-06 00:00:00
abstract：:Hyperlipidemia and the glomerular accumulation of atherogenic lipoproteins (low density lipoprotein, LDL; and its oxidatively-modified variants, ox-LDL) are commonly associated with the development of glomerular mesangial proliferative diseases. However, cellular signaling mechanisms by which atherogenic lipoproteins ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.08.010
更新日期：2008-10-24 00:00:00
abstract：:The effect of chronic cigarette smoke exposure on the activity of rat trachea and lung ornithine decarboxylase (ODC) and s-adenosyl-methionine decarboxylase (AdoMet-DC) was determined. Male rats were exposed once daily for 10 min to mainstream (MS) or different sidestream (SS) dilutions of fresh Kentucky 2R1 cigarette...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90567-3
更新日期：1985-12-09 00:00:00
abstract：:The effects of the novel anticonvulsant felbamate, which binds to the 5-7 dichlorokynurenic binding sites, were tested towards the CA1 epileptiform activity induced in rat hippocampal slices by kainic acid. The effects of the kynurenic acid derivatives 7-chlorokynurenic acid and 5-7 dichlorokynurenic acid and of the N...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00251-2
更新日期：1996-05-24 00:00:00
abstract：:Leukemias are a heterogenous group of diseases characterized by uncontrolled proliferation of abnormal blood cells of hematopoietic system. Evodiamine, a characteristic alkaloid extracted from Evodia fruits, has been reported to exhibit inhibitory effect on cell proliferation and migration in several types of cancer c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.11.025
更新日期：2004-05-21 00:00:00
abstract：:The effects of 1,3-dipropyl-8(p-sulfophenyl)xanthine (DPSPX) and enprofylline on the respiratory responses to bilateral occlusions of the common carotid arteries (CCO) were studied in rats anesthetized with sodium pentobarbitone and breathing spontaneously. CCO during periods of 5, 10 and 15 s caused increases in tida...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90208-7
更新日期：1989-01-01 00:00:00
abstract：:Ornithine decarboxylase (ODC) activity increases during many growth responses. Some cells and tissues in culture also exhibit elevated enzyme activity with decreasing osmolality of the culture medium. We have found that this also occurs with uterine tissue from ovariectomized rats. Organ culture incubation under hypot...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90551-4
更新日期：1984-03-26 00:00:00
abstract：:Ancylostoma ceylanicum, the human hookworm parasite, exhibited significant secretion of cholinesterase when maintained in vitro in RPMI-1640 medium. Secretion of the enzyme was linear up-to 4 hours of incubation. About 40 percent of the total cholinesterase activity was localized in the soluble fraction, while remaini...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90478-8
更新日期：1992-01-01 00:00:00
abstract：AIMS:Systemic administration of opiate analgesics such as morphine remains the most effective treatment for alleviating severe pain across a range of conditions including acute pain. However, chronic or repeated administration of opiate analgesics results in the development of analgesic tolerance. Glial cells such as m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.08.009
更新日期：2013-10-11 00:00:00
abstract：AIM:Membranous nephropathy remains the most common form of the nephrotic syndrome in adults. The combination therapy of steroid and cyclophosphamide has routinely been used. Although satisfactory therapeutic efficacy can be achieved, its side effect on reproductive system has been a concern. Mizoribine is an imidazole ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.04.012
更新日期：2016-06-01 00:00:00
abstract：:Rats implanted subcutaneously with an empty osmotic pump connected by a polyethylene catheter to a jugular vein for 5 to 10 days evinced a decreased splenocyte responsiveness to blastogenic stimulation in vitro to bacterial lipopolysaccharide, a known B cell stimulator, as well as to the plant mitogens pokeweed mitoge...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90291-v
更新日期：1992-01-01 00:00:00
abstract：:Contractile responses to norepinephrine (NE), and the population of beta-adrenoceptors, were determined in gastric fundus smooth muscle from rats with diabetes induced by streptozotocin (STZ), and age-matched controls. Relaxation and/or contraction of fundus strips of controls and diabetics were induced by 10(-5)M NE....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90505-6
更新日期：1991-01-01 00:00:00
abstract：:P120-catenin (P120) was known to function in adhesion between cells and signal transduction in many types of cells. In this study, we investigated the expression and role of P120 in pulmonary fibrosis and transforming growth factor beta (TGF-β) mediated lung fibroblast-to-myofibroblast differentiation (fibroblast diff...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.05.052
更新日期：2019-08-01 00:00:00
abstract：:The effect of the vasopressin neuropeptide des-glycinamide (Arg8)-vasopressin (DGAVP) on reducing the acquisition of intravenous heroin self-administration in rats was analyzed. When rats reduced in body weight were allowed to self-administer heroin for 1 h per day in the presence of a fixed time, non contingent food ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90565-6
更新日期：1988-01-01 00:00:00
abstract：:Uptake of serotonin and 3H-imipramine binding in platelets of depressed patients were investigated simultaneously with changes in clinical state. Both Vmax for serotonin uptake and Bmax for 3H-imipramine binding were significantly lower in unmedicated depressed patients with respect to normal subjects. Successful trea...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90201-2
更新日期：1985-02-25 00:00:00
abstract：:Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) we...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90139-0
更新日期：1985-09-30 00:00:00
abstract：:The leukotriene (LT) synthesis inhibitors BAY x1005 and MK-886 were evaluated in human lung parenchyma challenged with an anti-IgE. The anti-IgE-induced LTE4 release was time- and dose-dependent. Treatment of the parenchyma with indomethacin (3 microM) prior to anti-IgE challenge inhibited the 6-keto prostaglandin F1 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00426-2
更新日期：1996-01-01 00:00:00
abstract：:Experiments were done to examine the analgesic effect of thiorphan alone or in combination with stress in mice. Analgesia was assessed by measuring jump latencies from a 55 degrees C hot plate. Thiorphan exhibited weak analgesic properties evidenced by significant increases in jump latencies only after 300 mg/kg i.p. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90338-1
更新日期：1982-09-20 00:00:00
abstract：:Secreted frizzled-related protein 5 (Sfrp5) primarily acts in combination with wingless-type family member 5a (Wnt5a), to inhibits chronic inflammation and repress atherosclerosis and other metabolic disorders. Epicardial adipose tissue (EAT), surrounding the heart and coronary arteries, has been found to be highly re...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117338
更新日期：2020-03-15 00:00:00
abstract：AIM:Diabetic nephropathy (DN) is a leading cause of end-stage renal disease, and thus, the ability of antidiabetic drugs to ameliorate renal microvascular disease may be as important as their ability to control blood glucose. Therefore, we investigated the reno-protective effect of the antidiabetic drugs, Sitagliptin a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.03.043
更新日期：2016-05-15 00:00:00
abstract：:The present study is undertaken to investigate whether the phospholipase A(2) (PLA(2)) influences mRNA nucleocytoplasmic transport evaluated by nucleoside triphosphatase (NTPase) activity and mRNA export in isolated hepatic nuclear envelope. Isolated hepatic nuclei from rat liver were exposed to PLA(2) (10(-5) approxi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00357-6
更新日期：2003-07-11 00:00:00
abstract：:Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2015.01.006
更新日期：2015-04-01 00:00:00
abstract：:The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus. In the present studies, this pharmacologic procedure has been examined as a potential method for estimating hypothalamic ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90441-d
更新日期：1991-01-01 00:00:00
abstract：:The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main factors restricting the activation of the inflammasome, which is closely related to the abundance and localization of NLRP3. A substantial number of studie...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118918
更新日期：2021-02-15 00:00:00
abstract：:Male Sprague-Dawley rats were given a single electroconvulsive shock (ECS) on alternate days and sacrificed 48 hrs after 1, 3, or 5 seizures. The content of TRH in hippocampus, pyriform cortex and amygdala was increased 2.5-fold, 5.4-fold and 4.3-fold respectively, 48 hrs. after 3 alternate-day electroconvulsive shock...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90116-x
更新日期：1985-01-28 00:00:00
abstract：:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2004.05.034
更新日期：2004-11-05 00:00:00
abstract：:The feasibility of using human cells isolated from peritoneal dialysis effluent as a model for studying lipoprotein and cholesterol metabolism was investigated. Human peritoneal cells degraded low density lipoproteins (LDL) and acetylated LDL (acetyl-LDL) by saturable, high affinity receptor-mediated processes. Positi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00138-5
更新日期：1996-01-01 00:00:00
abstract：AIMS:The aims of the study are to investigate whether the combination of adipose-derived stem cells (ADSCs) with decellularized extracellular matrix (dECM) of myocardium can exert synergistic therapeutic effects on acute MI and the underlying mechanism. MAIN METHODS:Myocardial dECM from fresh porcine myocardium was pr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116891
更新日期：2019-12-15 00:00:00
