Role of dorsal raphe nucleus serotonin 5-HT1A receptor in the regulation of REM sleep.

abstract：:Responses to [Mpr14]-ADM(14-50), a novel analog of adrenomedullin, were investigated in the hindlimb vascular bed of the cat under conditions of controlled blood flow. Intraarterial injections of [Mpr14]-rADM(14-50) in doses of 0.003-1 nmol caused dose-related decreases in hindlimb perfusion pressure. In terms of rela...

journal_title：Life sciences

authors： Champion HC,Duperier CD,Fitzgerald WE,Lambert DG,Murphy WA,Coy DH,Kadowitz PJ

更新日期：1996-01-01 00:00:00

abstract：:Previous studies demonstrated a direct action of interleukin-1 (IL-1) on release of hormones from rat anterior pituitary cells in monolayer culture. To rule out any possibility of a paracrine effect from the elevated hormones in the static monolayer system, and to examine further the dynamics of hormone release elicit...

journal_title：Life sciences

authors： Beach JE,Smallridge RC,Kinzer CA,Bernton EW,Holaday JW,Fein HG

更新日期：1989-01-01 00:00:00

abstract：:Extracellular phospholipase A2 (PLA2) with proinflammatory activity has recently been discovered in synovial fluids in inflammatory arthritides. In the search for the sources of synovial fluid PLA2, human synovium and articular cartilage were found to contain large quantities of the enzyme. In rheumatoid arthritis (RA...

journal_title：Life sciences

authors： Pruzanski W,Bogoch E,Stefanski E,Wloch M,Vadas P

更新日期：1991-01-01 00:00:00

abstract：:Previous in vitro evidence suggests that adrenaline causes K influx in skeletal muscle by stimulating a ouabain sensitive Na/K ATPase membrane pump. However in rabbits, adrenaline induced hypokalaemia was not significantly altered by pretreatment with digoxin (50 micrograms/kg). Rats were infused with adrenaline or sa...

journal_title：Life sciences

authors： Struthers AD,Davies DL,Harland D,Price JS,Brown RA,Quigley C,Brown MJ

更新日期：1987-01-05 00:00:00

abstract：AIMS:Investigate the involvement of the histaminergic projections from tuberomammillary nucleus (TMN) to the spinal cord in the modulation of nociception and peripheral edema in a model of monoarthritis. MAIN METHODS:Subacute monoarthritis was induced by an intraarticular injection of carrageenan followed by LPS 72 h ...

journal_title：Life sciences

authors： Stein T,Tonussi CR

更新日期：2020-12-01 00:00:00

abstract：:Behavioral Hypersensitivity (BH) to dopamine agonists occurs following chronic treatment with most neuroleptics including haloperidol. In the present study we observed that the concurrent administration of thioridazine and haloperidol prevented the development of BH. In contrast, another neuroleptic, fluphenazine, coa...

journal_title：Life sciences

authors： Klawans HL,Carvey PM,Nelson D,Tanner CM,Goetz CG

更新日期：1986-05-12 00:00:00

abstract：:This study was essentially an in vivo protection experiment designed to test further the hypothesis that stress induces release of endogenous opioids which then act at opioid receptors. Rats that were either subjected to restraint stress for 1 hr or unstressed were injected ICV with either saline or 2.5 micrograms of ...

journal_title：Life sciences

authors： Adams JU,Andrews JS,Hiller JM,Simon EJ,Holtzman SG

更新日期：1987-12-28 00:00:00

abstract：:Previous behavioral studies on triazolam (TZ), which are small in number, could only speculate about tolerance to the anxiolytic effect of TZ, as the experiments did not cover sufficient time (of 4 to 7 days) for tolerance to develop. Therefore longer time for chronic TZ administration is used. We investigated the eff...

journal_title：Life sciences

authors： Aburawi SM,Elhwuegi AS,Ahmed SS,Saad SF,Attia AS

更新日期：2003-10-31 00:00:00

abstract：:Chronic voluntary running of mice is known to increase the circadian peak of plasma corticosterone without change in the level of adrenocorticotropic hormone (ACTH). In order to investigate how chronic exercise modulates the circadian HPA axis, we used two weeks of voluntary wheel running of mice and confirmed the sig...

journal_title：Life sciences

authors： Otawa M,Arai H,Atomi Y

更新日期：2007-01-30 00:00:00

abstract：:Opioid peptides have been demonstrated to stimulate prolactin secretion, and it has been postulated that this is mediated, at least in part, by an effect on hypothalamic prolactin releasing and release-inhibiting factors and neurotransmitters. The aim of this study was to investigate the effect of opioid peptides and ...

journal_title：Life sciences

authors： Burns G,Baker DJ,Brown BL,Dobson PR

更新日期：1987-03-09 00:00:00

abstract：:11Beta-hydroxyglucocorticoids (HGCs) are known to induce apoptosis in immature T cells. Here we show that 11-oxoglucocorticoids (OGCs), which are oxidized metabolites of HGCs, counteract the apoptosis-inducing effects of HGC in murine thymocytes in vitro. Corticosterone at concentrations ranging from 0.1-100 microM in...

journal_title：Life sciences

authors： Hirano T,Horigome H,Ishishita H,Uda S,Oka K

更新日期：2001-05-18 00:00:00

abstract：:Despite the considerable number of published studies in the field of S-nitrosothiols (RSNO), the determination of these compounds in biological samples still represents an analytical challenge, due to several technical obstacles and often long sample preparation procedures. Other problems derive from the intrinsic lab...

journal_title：Life sciences

authors： Bramanti E,Angeli V,Paolicchi A,Pompella A

更新日期：2011-01-17 00:00:00

abstract：AIMS:Constant development of chemotherapeutic strategies has considerably improved the efficiency of tumor treatment. However, adverse effects of chemotherapeutics enforce premature treatment cessation, which leads to the tumor recurrence and accelerated death of oncologic patients. Recently, sodium ascorbate (ASC) has...

journal_title：Life sciences

authors： Ryszawy D,Pudełek M,Catapano J,Ciarach M,Setkowicz Z,Konduracka E,Madeja Z,Czyż J

更新日期：2019-09-01 00:00:00

abstract：:Melanin in the skin determines the skin color, and decreased melanin causes many hypopigmentation disorders and increased damage to skin by ultraviolet B (UVB) light irradiation. Here, we stimulate melanogenesis in B16F10 melanoma cells by using specific frequencies of ELF-EMFs. In this study, we focus on the melanoge...

journal_title：Life sciences

authors： Kim YM,Cho SE,Seo YK

更新日期：2016-10-01 00:00:00

abstract：:Stonustoxin (SNTX) is a 148 kDa, dimeric, hypotensive and lethal protein factor isolated from the venom of the stonefish Synanceja horrida. SNTX (10-320 ng/ml) progressively causes relaxation of endothelium-intact, phenylephrine (PE)-precontracted rat thoracic aortic rings. The SNTX-induced vasorelaxation was inhibite...

journal_title：Life sciences

authors： Liew HC,Khoo HE,Moore PK,Bhatia M,Lu J,Moochhala SM

更新日期：2007-04-10 00:00:00

abstract：:NMDA receptors are glutamate-regulated ion channels of critical importance for many neurophysiological and neuropathological processes. Mg2+ blocks the NMDA receptor by binding to the channel pore with an apparent affinity that depends on the membrane potential. We have investigated the effect of NMDA and the required...

journal_title：Life sciences

authors： Liu Y,Hill RH,Arhem P,von Euler G

更新日期：2001-03-09 00:00:00

abstract：:To characterize the mechanism of the analgesic action of H1 antihistaminics the effects of a new, highly selective agonist, 2-(3-trifluoromethylphenyl)histamine dihydrogenmaleate (FMPH), and of the better known H1 agonist, 2-thiazolylethylamine (2-TEA), were studied on pain threshold by means of three different kinds ...

journal_title：Life sciences

authors： Malmberg-Aiello P,Lamberti C,Ipponi A,Bartolini A,Schunack W

更新日期：1998-01-01 00:00:00

abstract：:There is increasing evidence that the 5'UTR of mRNAs affects regulation of gene expression in eukaryotic cells. We examined the overexpression of the mu-opioid receptor in High Five insect cells, employing rat mu-receptor cDNA linked to variable lenghts of their native 5'UTR. The sequences employed consist of either 2...

journal_title：Life sciences

authors： Belke-Louis GF,Wehmeyer A,Schulz R

更新日期：1999-01-01 00:00:00

abstract：:The molecular dynamics (MD) simulations study in the formation of the complex between compound SWR-0342SA and beta-ARs suggested that upon binding SWR-0342SA stimulates receptor activation through residues network (Asp104, Leu335 in beta(1)-AR; Asp117, Ser209, Leu303, Ser191 in beta(3)-AR) in an active conformation st...

journal_title：Life sciences

authors： Ahmed M,Ishiguro M,Nagatomo T

更新日期：2006-03-20 00:00:00

abstract：:Castration increases the central nervous system (CNS) sensitivity to hexobarbital as measured by an EEG-threshold method. Testosterone treatment in doses from 1 to 5 mg/kg/day decreases CNS-sensitivity and restores threshold values in castrated rats to a level found in normal young adult male rats. ...

journal_title：Life sciences

authors： Bolander HG,Kourtopoulos H

更新日期：1985-03-11 00:00:00

abstract：AIMS:A bridging ligand 2,4,6-pyridine tricarboxylic acid (H(3)ptc) and its manganese(II) complex [Mn(Hptc)(phen)(OH)]n(Hptc=2,4,6-pyridine tricarboxylic acid, phen=1,10-phenanthroline) have been synthesized and characterized. MAIN METHODS:The interaction with DNA (HeLa and KB) was carried out by fluorescence spectrum ...

journal_title：Life sciences

authors： Zhu M,He W,Gao E,Lin L,Zhang Y,Dai L,Wang R,Wang B,Wang M

更新日期：2012-04-09 00:00:00

abstract：:The regions of muscarinic receptors that specify G-protein-coupling and ligand-binding have been defined in several recent studies. Overall, these studies have shown that amino acids within the third cytoplasmic loop of the receptors define their selectivity for different G-proteins, and that multiple, discontinuous e...

journal_title：Life sciences

authors： Brann MR,Klimkowski VJ,Ellis J

更新日期：1993-01-01 00:00:00

abstract：:In critically ill patients various conditions may lead to the activation of poly(ADP-ribose) polymerase (PARP). By promoting cellular energetic dysfunction, and by enhancing pro-inflammatory gene expression, PARP activation significantly contributes to the pathogenesis of shock. PARP activation is usually triggered by...

journal_title：Life sciences

authors： Horváth EM,Benko R,Gero D,Kiss L,Szabó C

更新日期：2008-01-16 00:00:00

abstract：:The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible ...

journal_title：Life sciences

authors： Pertwee RG

更新日期：1999-01-01 00:00:00

abstract：AIMS:Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. MAIN METHODS:Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assay...

journal_title：Life sciences

authors： Sogawa N,Hirai K,Sogawa C,Ohyama K,Miyazaki I,Tsukamoto G,Asanuma M,Sasaki A,Kitayama S

更新日期：2013-04-09 00:00:00

abstract：:An increase in the weight of the thyroid gland, accompanied by reductions in uptake and release of 1311, serum T3 and reverse T3 concentrations and an increase in serum TSH concentration, occurs during the development of renal hypertension in rats. Renal function, as assessed by BUN, serum and urinary creatinine conce...

journal_title：Life sciences

authors： Fregly MJ,Threatte RM

更新日期：1982-02-15 00:00:00

abstract：:The systemic administration of neurotensin (NT) dose-dependently increased plasma adrenocorticotropin (ACTH) concentration in rats, and this effect was annulled by (alpha-helical)-CRH9-41, an antagonist of corticotropin-releasing hormone (CRH). The systemic administration of [D-Trp11]-neurotensin (NT-A), a specific NT...

journal_title：Life sciences

authors： Nussdorfer GG,Malendowicz LK,Meneghelli V,Mazzocchi G

更新日期：1992-01-01 00:00:00

abstract：:Microiontophoretic study was performed to elucidate dopaminergic mechanism in the nucleus accumbens (Acc) of rats anesthetized with chloral hydrate. Iontophoretically applied dopamine produced an inhibition of glutamate-induced firing in 28 (62%) out of 45 Acc neurons tested. The dopamine-induced inhibition of 14 Acc ...

journal_title：Life sciences

authors： Akaike A,Sasa M,Takaori S

更新日期：1983-06-06 00:00:00

abstract：:The scientific interest in irisin, a myokine discovered in 2012, has grown exponentially in recent years. Irisin, which is mainly produced in skeletal muscle, influences the browning process of adipose tissue and lipid and energy metabolism. Recent discoveries highlight that the potential of this hormone may have been...

journal_title：Life sciences

authors： Flori L,Testai L,Calderone V

更新日期：2021-02-15 00:00:00

abstract：:We studied the different effects of three kinds of somatostatin (somatostatin 1-14, somatostatin 15-28, somatostatin 1-28) on the aggregation of rabbit's platelets. It was clarified that somatostatin 15-28 had inhibitory effects on rabbit's platelet aggregation stronger than somatostatin 1-14 did, and that somatostati...

journal_title：Life sciences

authors： Fuse I,Ito S,Takagi A,Shibata A

更新日期：1985-05-27 00:00:00