Molecular modeling of SWR-0342SA, a beta3-selective agonist, with beta1- and beta3-adrenoceptor.

abstract：:Catecholamine uptake into PC12 cells, in the presence and absence of ATP, was measured in a bicarbonate-buffered Krebs Ringer. ATP enhanced significantly the uptake in a dose-dependent manner with maximal uptake at 1-3 mM. ATP increased the Vmax of uptake by 3-5 fold for both dopamine and norepinephrine, without a sig...

journal_title：Life sciences

authors： Eshleman A,Dunigan C,Shamoo A,Eldefrawi M

更新日期：1995-01-01 00:00:00

abstract：:We have examined factors that alter the effect of diazepam (DZ) on plasma corticosterone (CS) in rats. DZ had a biphasic effect on plasma CS levels: CS decreased with doses below 5 mg/kg and increased with higher doses. Peak response occurred 90 minutes post injection in both sexes. Plasma DZ levels were significantly...

journal_title：Life sciences

authors： Pohorecky LA,Cotler S,Carbone JJ,Roberts P

更新日期：1988-01-01 00:00:00

abstract：:Nitric oxide (NO) is the mediator of ischemic preconditioning against myocardial infarction. Desflurane produces anesthetic preconditioning to protect the myocardium against infarction. In the model of myocardial ischemia-reperfusion injury in rabbits, we evaluated desflurane-induced ischemic preconditioning and studi...

journal_title：Life sciences

authors： Tsai SK,Lin SM,Huang CH,Hung WC,Chih CL,Huang SS

更新日期：2004-12-24 00:00:00

abstract：:Malaria is a major health problem in many countries and according to an estimate of the WHO, more than 500 million infections occur per year. Artemisinin, a sesquiterpene from Artemisia annua L., has received considerable attention as a promising and potent antimalarial drug for its stage speciticity, its rather low t...

journal_title：Life sciences

authors： Bilia AR,Lazari D,Messori L,Taglioli V,Temperini C,Vincieri FF

更新日期：2002-01-04 00:00:00

abstract：:We investigated the effects of ketanserin, a S 2 (5-hydroxytryptamine 2; 5-HT 2)-serotonergic receptor antagonist, on cerulein-induced pancreatitis in the rat. Large pharmacological doses of cerulein induced acute pancreatitis in the rat. Ketanserin reduced the cerulein-induced increase in serum amylase concentration ...

journal_title：Life sciences

authors： Oguchi H,Terashima M,Koiwai T,Kawa S,Furuta S,Kobayashi M,Homma T

更新日期：1992-01-01 00:00:00

abstract：:The drug transporter, multidrug resistance-associated protein 2 (ABCC2/Mrp2), is known to play important roles in excretion of various drugs. In the present study, we investigated whether Mrp2 is involved in the transport of micafungin, a newly developed antifungal agent. When Sprague-Dawley rats received an intraveno...

journal_title：Life sciences

authors： Abe F,Ueyama J,Kimata A,Kato M,Hayashi T,Nadai M,Saito H,Takeyama N,Noguchi H,Hasegawa T

更新日期：2008-08-15 00:00:00

abstract：AIMS:Toll-like receptor (TLR)9 ligand CpG-oligodeoxynucleotide (CpG-ODN) exerts preconditioning in myocardial ischemia/reperfusion. We hypothesized a postconditioning effect of CpG-ODN in a murine closed-chest model of myocardial infarction. MATERIALS AND METHODS:C57BL/6 (12 weeks, male, WT) mice were instrumented at ...

journal_title：Life sciences

authors： Kim SC,Wu S,Fang X,Neumann J,Eichhorn L,Schleifer G,Boehm O,Meyer R,Frede S,Hoeft A,Baumgarten G,Knuefermann P

更新日期：2014-12-05 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic, and HAM/TSP...

journal_title：Life sciences

authors： Fuzii HT,da Silva Dias GA,de Barros RJ,Falcão LF,Quaresma JA

更新日期：2014-05-28 00:00:00

abstract：:Environmental estrogens (endocrine disruptive chemicals) have been shown to affect reproduction in wild life and it has been reported that maternal exposure with those chemicals have adverse effects on the male reproductive tract. However, little is known about the potential effects of prepubertal or pubertal exposure...

journal_title：Life sciences

authors： Takao T,Nanamiya W,Nagano I,Asaba K,Kawabata K,Hashimoto K

更新日期：1999-01-01 00:00:00

abstract：:Previous studies from this laboratory have shown that rats with experimental cirrhosis of the liver induced by the combined administration of oral phenobarbital and inhaled carbon tetrachloride show an hyperdynamic status with enhanced cardiac output (CO), and decreased mean arterial pressure (MAP) and peripheral vasc...

journal_title：Life sciences

authors： Villamediana LM,Sanz E,Fernandez-Gallardo S,Caramelo C,Sanchez Crespo M,Braquet P,Lopez-Novoa JM

更新日期：1986-07-21 00:00:00

abstract：:Endogenous opioid peptides have been implicated in the pathophysiology of shock (1-5). In anaesthetised mongrel dogs, administration of E coli endotoxin caused a rise in plasma met-enkephalin-like immunoreactivity (MLI). Biochemical characterisation of MLI by gel filtration chromatography revealed various molecular fo...

journal_title：Life sciences

authors： Evans SF,Medbak S,Hinds CJ,Tomlin SJ,Varley JG,Rees LH

更新日期：1984-04-09 00:00:00

abstract：AIMS:The aim of this study was to investigate the effects of a mood stabilizer lamotrigine (LMG) on learning and memory processes using Morris water maze (MWM), modified elevated plus maze (mEPM) and passive avoidance (PA) tests. MAIN METHODS:Balb-c mice were used. LMG were injected (20; 40mg/kg, intraperitoneal, i.p....

journal_title：Life sciences

authors： Celikyurt IK,Ulak G,Mutlu O,Akar FY,Erden F,Komsuoglu SS

更新日期：2012-12-17 00:00:00

abstract：:Although both the incidence and the mortality rate of breast cancer is rising, there is no potent and practical option for the treatment of these patients, particularly in advanced stages. One of the most critical challenges for treatment is the presence of complicated and extensive tumor escape mechanisms in the tumo...

journal_title：Life sciences

authors： Bastaki S,Irandoust M,Ahmadi A,Hojjat-Farsangi M,Ambrose P,Hallaj S,Edalati M,Ghalamfarsa G,Azizi G,Yousefi M,Chalajour H,Jadidi-Niaragh F

更新日期：2020-04-15 00:00:00

abstract：:In order to further elucidate a possible role of neuropeptides and GABA in the pathogenesis of febrile convulsions, we studied changes of immunoreactive-arginine vasopressin (IR-AVP), IR-somatostatin (IR-SRIF) and gamma-aminobutyric acid (GABA) in the rat brain after febrile convulsions induced by ultra-red light (UR)...

journal_title：Life sciences

authors： Nagaki S,Nagaki S,Minatogawa Y,Sadamatsu M,Kato N,Osawa M,Fukuyama Y

更新日期：1996-01-01 00:00:00

abstract：:Mucosal mast cells are implicated in visceral hypersensitivity associated with irritable bowel syndrome (IBS). In this study, we investigated the role of mast cells in the development of visceral hypersensitivity by using mast cell deficient (Ws/Ws) rats and their control (W+/W+). In W+/W+ rats, an injection of 2,4,6-...

journal_title：Life sciences

authors： Ohashi K,Sato Y,Kawai M,Kurebayashi Y

更新日期：2008-02-13 00:00:00

abstract：:Sodium spirulan (Na-SP) is a sulfated polysaccharide with M(r) approximately 220,000 isolated from the blue-green alga Spirulina platensis. The polysaccharide consists of two types of disaccharide repeating units, O-hexuronosyl-rhamnose (aldobiuronic acid) and O-rhamnosyl-3-O-methylrhamnose (acofriose) with sulfate gr...

journal_title：Life sciences

authors： Kaji T,Okabe M,Shimada S,Yamamoto C,Fujiwara Y,Lee JB,Hayashi T

更新日期：2004-03-26 00:00:00

abstract：:The concentrations and molecular forms of urinary and plasma gastrin from normal subjects were studied by radioimmunoassays using two region-specific antisera. Urinary concentration of NH2-terminal big gastrin (G-34) immunoreactivity was several hundred times as great as that of COOH-terminal gastrin immunoreactivity....

journal_title：Life sciences

authors： Higashimoto Y,Himeno S,Shinomura Y,Kanayama S,Nagao K,Tarui S

更新日期：1990-01-01 00:00:00

abstract：:We examined whether H(+)-ATPase is involved in the control of cellular action of arginine vasopressin (AVP) to produce adenosine 3', 5'-monophosphate (cAMP) and mobilize cellular free calcium ([Ca2+]i) in rat renal papillary collecting tubule cells in culture. N-Ethylmaleimide (NEM), an inhibitor of H(+)-ATPase, reduc...

journal_title：Life sciences

authors： Ishikawa S,Sakuma N,Okada K,Saito T

更新日期：1993-01-01 00:00:00

abstract：:The in vivo effect of trazodone on the density of [(3)H]5-HT binding sites and 5-HT(1A) receptors and adenylyl cyclase (AC) response was studied in regions of rat brain. The chronic administration of trazodone (10 mg/Kg body wt, 40 days) resulted in a significant downregulation of [(3)H]5-HT binding sites and 5-HT(1A)...

journal_title：Life sciences

authors： Subhash MN,Srinivas BN,Vinod KY

更新日期：2002-08-16 00:00:00

abstract：:Following a report that nortriptyline was found useful in the control of enuresis in adults, presumably as an anticholinergic, its likely mechanism of action and apparent bladder specificity have now been investigated in vitro. The ratios of anticholinergic potencies (reciprocal of dissociation contents, Ki) for four ...

journal_title：Life sciences

authors： Rehavi M,Weiss H,Nissenkorn I,Rubinstein R,Cohen S

更新日期：1987-05-04 00:00:00

abstract：:A series of cyclic conformationally restricted penicillamine containing somatostatin octapeptide analogues have been prepared by standard solid phase synthetic techniques and tested for their ability to inhibit specific [125I]CGP 23,996 (des-Ala1-,Gly2-[desamino-Cys3Tyr11]-dicarba3, 14-somatostatin), [3H]naloxone or [...

journal_title：Life sciences

authors： Gulya K,Pelton JT,Hruby VJ,Yamamura HI

更新日期：1986-06-16 00:00:00

abstract：:N-acyl dehydroalanines have been shown to react with and scavenge oxygen derived free radicals. One of those compounds, the AD-5 (N-(paramethoxyphenylacetyl) dehydroalanine) has been examined for its ability to decrease the amount of reactive oxygen species which appeared when liver microsomes (isolated from rats pret...

journal_title：Life sciences

authors： Buc-Calderon P,Roberfroid M

更新日期：1990-01-01 00:00:00

abstract：:A number of studies have been made on the role played by endogenous opioid peptides in the secretion of LH in humans. However no previous studies have compared the effects of the most potent pharmacological agonist and antagonist, morphine and naloxone, in the same subjects. The present study examined the acute effect...

journal_title：Life sciences

authors： Petraglia F,Porro C,Facchinetti F,Cicoli C,Bertellini E,Volpe A,Barbieri GC,Genazzani AR

更新日期：1986-06-09 00:00:00

abstract：:A mechanism of antidepressant activity of beta-amyrin palmitate was studied using the forced swimming method in mice. Beta-amyrin palmitate (10 mg/kg) reduced the increase in the duration of immobility induced by tetrabenazine (100 and 200 mg/kg), but showed no effect on that in mice treated with alpha-methyl-para-tyr...

journal_title：Life sciences

authors： Subarnas A,Tadano T,Nakahata N,Arai Y,Kinemuchi H,Oshima Y,Kisara K,Ohizumi Y

更新日期：1993-01-01 00:00:00

abstract：:In the course of investigating the binding of imipramine to soluble cellular fractions from brain and leukocytes using equilibrium dialysis, an artifactual binding component was produced. On Scatchard and double-reciprocal plots of the data, the component appeared as a homogenous population of sites displaying a bindi...

journal_title：Life sciences

authors： Cullen EI,Medzihradsky F

更新日期：1983-07-11 00:00:00

abstract：:Plasma opioid levels were determined in 9 obese non-diabetic subjects, their 8 age matched controls, and in 29 diabetic patients; 10 maintained on diet alone, 6 on an oral hypoglycemic agent (chlorpropamide) and 13 treated with insulin. Five age matched controls for the diabetic groups were also studied for comparison...

journal_title：Life sciences

authors： Awoke S,Voyles NR,Bhathena SJ,Tanenberg RJ,Recant L

更新日期：1984-05-21 00:00:00

abstract：:We investigated the effects of the chronic administration of hesperetin on the activation of the antioxidant defence system in mice in which oxidative stress had been induced by 7,12-dimethylbenz(a)anthracene (DMBA). Mice were divided randomly into three treatment groups. Hesperetin was administered orally to two of t...

journal_title：Life sciences

authors： Choi EJ

更新日期：2008-05-23 00:00:00

abstract：:The anticonvulsant effects and duration of protective action of midazolam against Metrazol induced seizures were studied in 528 rats aged 7,12,18,25 and 90 days. The doses of 0.025, 0.05, 0.25, 0.5 and 1.0 mg/kg were administered immediately before Metrazol (100 mg/kg in all but 18-day-old animals where 90 mg/kg were ...

journal_title：Life sciences

authors： Kubová H,Mares P

更新日期：1992-01-01 00:00:00

abstract：:The antiarrhythmic and cardioprotective drug stobadine, possessing antioxidant and neuroprotective properties, was studied as to its in vitro effect on aggregation of human blood platelets. Pretreatment of platelets with stobadine for 30 s inhibited stimulated platelet aggregation in a dose-dependent way. Depending on...

journal_title：Life sciences

authors： Jancinová V,Nosál R,Danihelová E

更新日期：1999-01-01 00:00:00

abstract：:Incubation of the nonsteroidal antiestrogen nitromiphene (CI628) with rat cecal content suspension under aerobic or anaerobic conditions resulted in extensive biotransformation, yielding three metabolites, as determined by thin-layer chromatography. These metabolites were not recovered from incubation mixtures contain...

journal_title：Life sciences

authors： Ruenitz PC,Bagley JR

更新日期：1983-09-12 00:00:00