Morphine tolerance in arthritic rats and serotonergic system.

abstract：:Angiotensin (AII) and atrial natriuretic peptide (ANP) exert opposite effects on phosphorylation of a 17.6 kDa nuclear protein from bovine adrenal glomerulosa cells. The protein was separated by sodium dodecyl sulfate electrophoresis and blotted onto polyvinylidene difluoride, and the N-terminal sequence was obtained....

journal_title：Life sciences

authors： Elliott ME

更新日期：1990-01-01 00:00:00

abstract：:In a series of in vitro experiments we characterised the relationship between DNA distribution in the G1, S and G2/M phases of cell cycle and PDE and GST activity in CaCo-2 cells. The DNA distribution in CaCo-2 cells, was assessed by flow cytometry, with fluorescent dyes at different time points of culture. The expone...

journal_title：Life sciences

authors： Savini F,Berardi S,Tatone D,Spoto G

更新日期：1995-01-01 00:00:00

abstract：:Tobacco smoke (TS) is a potent source of oxidants and oxidative stress is an important mechanism by which TS exerts its toxicity in the lung. We have shown that TS induces heat shock (HS)/stress protein (HSP) synthesis in human monocytes. Pulmonary surfactant (PS) whose major physiological function is to confer mechan...

journal_title：Life sciences

authors： Pinot F,Bachelet M,François D,Polla BS,Walti H

更新日期：1999-01-01 00:00:00

abstract：:Over the past few years, it has been reported that physical and psychological stress elevate plasma interleukin-6 (IL-6), and that neural cells can produce IL-6 and have receptors for IL-6 (IL-6R). However, it is unknown whether IL-6 plays a role in regulating the functions of neural cells in response to stress. We de...

journal_title：Life sciences

authors： Shizuya K,Komori T,Fujiwara R,Miyahara S,Ohmori M,Nomura J

更新日期：1998-01-01 00:00:00

abstract：:The binding of norepinephrine (NE) to plasma proteins of fresh human blood obtained from healthy volunteers was studied by ultrafiltration at different NE concentrations and incubation times at 37 degrees C. At 1.7 nM L-[3H]-NE binding was approximately 25%. The binding was rapid and was not influenced by the incubati...

journal_title：Life sciences

authors： de Vera N,Cristófol RM,Rodríguez Farré E

更新日期：1988-01-01 00:00:00

abstract：AIMS:GnRH-DFF40 (gonadotropin releasing hormone-DNA fragmentation factor 40) humanized recombinant immunotoxin serves as a prospective candidate for targeted therapy of malignancies with over-expressed gonadotropin releasing hormone receptor (GnRHR). In this study, we attempted to generate a GnRH-based chimeric protein...

journal_title：Life sciences

authors： Barazesh M,Mohammadi S,Jalili S,Kavousipour S,Faraji SN,Mokarram P,Pirhadi S

更新日期：2021-01-15 00:00:00

abstract：:We previously demonstrated that tissue-type plasminogen activator (t-PA) specifically bound to its receptor (t-PAR) on human umbilical vein endothelial cells (HUVEC). In addition to analyses of t-PA binding to plasminogen activator inhibitor-1 (PAI-1) in the extracellular matrix (ECM) and to the t-PAR, we further eval...

journal_title：Life sciences

authors： Fukao H,Ueshima S,Okada K,Matsuo O

更新日期：2000-01-01 00:00:00

abstract：AIMS:To examine the effects of metoprolol on expression of myocardial inflammatory cytokines and myocardial function in rats following coronary microembolization (CME). MAIN METHODS:Male rats were randomly assigned to receive either sham-operation (control group), CME plus saline (CME group), or CME plus metoprolol (m...

journal_title：Life sciences

authors： Lu Y,Li L,Zhao X,Huang W,Wen W

更新日期：2011-06-06 00:00:00

abstract：:Several different vasodilator substances can be released by vascular endothelium in response to mechanical stimuli and vasoactive agents. The purpose of this study was to determine whether there is a male-female difference in the relative contributions of nitric oxide (NO) and endothelium-derived hyperpolarizing facto...

journal_title：Life sciences

authors： Pak KJ,Geary GG,Duckles SP,Krause DN

更新日期：2002-08-23 00:00:00

abstract：:Synthetic human pancreatic Growth Hormone-Releasing Factor (hpGRF) elevated the plasma concentration of growth hormone (GH) in young and adult domestic fowl. This in vivo effect of hpGRF appeared to be largely similar for both the 32 amino-acid (hpGRF 1-32) or 40 amino-acid (hpGRF 1-40) polypeptide, although the effec...

journal_title：Life sciences

authors： Scanes CG,Carsia RV,Lauterio TJ,Huybrechts L,Rivier J,Vale W

更新日期：1984-03-19 00:00:00

abstract：:Many persistent pesticides have been implicated in reproductive and developmental adverse effects, in man and wildlife. It has been hypothesized that these so-called xeno-hormones could upset the endocrine system function by binding to human estrogen receptor alpha and beta (ERalpha, beta) and thus be responsible for ...

journal_title：Life sciences

authors： Lemaire G,Mnif W,Mauvais P,Balaguer P,Rahmani R

更新日期：2006-08-15 00:00:00

abstract：:Neuropeptide Y (NPY) is a major hypothalamic peptide which is implicated in the regulation of energy balance and in the activation of the hypothalamo-pituitary adrenal axis. This study aimed primarily to determine the effects on regional hypothalamic NPY levels, of catabolism and weight loss induced in rats by the syn...

journal_title：Life sciences

authors： McKibbin PE,Cotton SJ,McCarthy HD,Williams G

更新日期：1992-01-01 00:00:00

abstract：:This study analyses possible changes during surgical and chemical castration in the expression and pharmacological characteristics of alpha1-adrenoceptor in adult rat seminal vesicle. Ribonuclease protection assays indicated that alpha1a--was the predominant mRNA, while alpha1b-and alpha1d-adrenoceptor transcripts wer...

journal_title：Life sciences

authors： Mendes FR,Hamamura M,Queiróz DB,Porto CS,Avellar MC

更新日期：2004-08-06 00:00:00

abstract：:Aminoalkylindoles (AAIs) are structurally dissimilar from the classical cannabinoids (CCs), however, both AAIs and CCs appear to bind at the same site on the cannabinoid receptor. To obtain better insights on the structural correlation between AAIs and CCs, we have studied the conformational properties of the potent c...

journal_title：Life sciences

authors： Xie XQ,Eissenstat M,Makriyannis A

更新日期：1995-01-01 00:00:00

abstract：AIMS:To potentiate the well-documented tumor protecting ability of paullones, literatures demand for rational modifications in paullone ring structure and exploration of a precise mechanism underlying their antitumor effects. Thus, recently we synthesized novel paullone-like scaffold, 5H-benzo [2, 3][1,4]oxazepino[5,6-...

journal_title：Life sciences

authors： Singh AK,Bhadauria AS,Kumar U,Raj V,Maurya V,Kumar D,Maity B,Prakash A,De A,Samanta A,Saha S

更新日期：2018-05-15 00:00:00

abstract：:Calcium mobilization has been demonstrated to possess functional importance in myocardial excitation-contraction as well as cellular metabolism. So far, much progress has been made to explore the possibility of involvement of guanine nucleotide binding regulatory protein in the opening and closing of calcium channels ...

journal_title：Life sciences

authors： Fu LX,Waagstein F,Hjalmarson A

更新日期：1991-01-01 00:00:00

abstract：:The extended infection with Helicobacter pylori (H. pylori), one of the most frequent infectious agents in humans, may cause gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. During H. pylori infection, different kinds of inflammatory cells such as dendritic cells...

journal_title：Life sciences

authors： Jafarzadeh A,Nemati M,Jafarzadeh S

更新日期：2019-08-15 00:00:00

abstract：:The anti-secretory activity of the competitive H2-antagonist HUK 978 was determined in rat, guinea-pig and dog. In all systems examined, HUK 978 was more potent than cimetidine and ranitidine both intravenously and orally. In addition, the compound at approximately equipotent doses as these established H2-antagonists ...

journal_title：Life sciences

authors： Coombes JD,Norris DB,Rising TJ,Ross BC,Steward A

更新日期：1985-11-04 00:00:00

abstract：:Rats were made sensitive to the effects of the opioid antagonist naltrexone by treating them once weekly with cumulative doses of the drug (1, 3, 10, 30 and 100 mg/kg). Sensitization was monitored by measuring salivation following naltrexone administration. During the first week of treatment, no salivation was noted f...

journal_title：Life sciences

authors： Schindler CW,Marley RJ,Goldberg SR

更新日期：1992-01-01 00:00:00

abstract：:Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidin...

journal_title：Life sciences

authors： Maccarrone C,Jarrott B

更新日期：1988-01-01 00:00:00

abstract：:Our recent report demonstrated that apoptosis-specific autoantibodies against granzyme B-induced cleavage fragments of SS-B (La) were found in the sera from patients with primary Sjögren's syndrome. The objective of this study was identified by the intracellular redistribution of La autoantigen during granzyme B-induc...

journal_title：Life sciences

authors： Huang M,Ida H,Arima K,Nakamura H,Aramaki T,Fujikawa K,Tamai M,Kamachi M,Kawakami A,Yamasaki H,Origuchi T,Eguchi K

更新日期：2007-10-27 00:00:00

abstract：:Accumulation of excess fluoride in the environment poses serious health risks to plants, animals, and humans. This endangers human health, affects organism growth and development, and negatively impacts the food chain, thereby affecting ecological balance. In recent years, numerous studies focused on the molecular mec...

journal_title：Life sciences

authors： Zuo H,Chen L,Kong M,Qiu L,Lü P,Wu P,Yang Y,Chen K

更新日期：2018-04-01 00:00:00

abstract：:The compound (+)-MR200 [(+)-methyl (1R,2S)-2-{[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate] is a sigma ligand with increased affinity and selectivity compared to the structurally related ligand haloperidol. From the results of a previous study on the modulation of a systemically ...

journal_title：Life sciences

authors： Marrazzo A,Parenti C,Scavo V,Ronsisvalle S,Scoto GM,Ronsisvalle G

更新日期：2006-04-18 00:00:00

abstract：:The effects of cloricromene, a coumarine derivative, were studied in an anaesthetized rat model of coronary artery ligation (60 min) followed by reperfusion (60 min; MI/R). Sham operated rats were used as controls (Sham MI/R). Myocardial ischaemia-reperfusion injury produced a marked myocardial injury (necrotic area/a...

journal_title：Life sciences

authors： Squadrito F,Altavilla D,Zingarelli B,Ioculano M,Calapai G,Campo GM,Miceli A,Prosdocimi M,Caputi AP

更新日期：1993-01-01 00:00:00

abstract：:In order to explore the effect of neonatal androgen administration on oocyte quality, ovulation induction and in vitro fertilization (IVF) were performed in androgen-sterilized mice. Androgen sterilized mice were produced by the subcutaneous injection of testosterone propionate (TP) at 5 days of age and ovulation indu...

journal_title：Life sciences

authors： Kamijo T,Mizunuma H,Yamada K,Ibuki Y

更新日期：1994-01-01 00:00:00

abstract：:Administration of cyclosporine (CS) as an immunosuppressive agent in clinical transplantation is associated with multiple side effects including nephrotoxicity and hypertension. These two effects could be related in that the renal changes may be secondary to alterations in organ blood flow. The present studies investi...

journal_title：Life sciences

authors： Lamb FS,Webb RC

更新日期：1987-06-29 00:00:00

abstract：AIM:Physical exercise is important in the prevention and treatment of cardiovascular diseases. Nevertheless, controversy remains around type and intensity of effort required for significant biochemical protective changes. This study investigates two exercise protocols on ventricular oxidative parameters in rats post-in...

journal_title：Life sciences

authors： Pinho CA,Tromm CB,Tavares AM,Silva LA,Silveira PC,Souza CT,Benetti M,Pinho RA

更新日期：2012-04-09 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) is a proliferative disorder characterized by enhanced proliferation and suppressed apoptosis of intrapulmonary vascular smooth muscle cells. Recently, network-based bioinformatics have identified let-7 family, a tumor suppressive microRNA, regulate multiple interacting targets relevant ...

journal_title：Life sciences

authors： Zhang WF,Xiong YW,Zhu TT,Xiong AZ,Bao HH,Cheng XS

更新日期：2017-02-01 00:00:00

abstract：:This review aims to systematically review and synthesize scientific evidence for the influence of air pollution exposure and outdoor exercise on health. We conducted a literature search in the PubMed, Cochrane, EMBASE, and Web of Science for articles that evaluated the combination effect of air pollution exposure and ...

journal_title：Life sciences

authors： Qin F,Yang Y,Wang ST,Dong YN,Xu MX,Wang ZW,Zhao JX

更新日期：2019-02-01 00:00:00

abstract：:In murine splenocytes, a primary antigen-specific antibody response is stimulated by 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), a stable form of ascorbate, as described in our previous paper. We examined here the effect of nerve growth factor (NGF) on the antigen-specific antibody production in vitro augmente...

journal_title：Life sciences

authors： Yanagida M,Gohda E,Yamamoto I

更新日期：1996-01-01 00:00:00