Effect of some acute and prophylactic antimigraine drugs on the vasodepressor sensory CGRPergic outflow in pithed rats.

abstract：:The activation of cholinergic pathways by nicotine elicits various physiological and pharmacological effects in mammals. For example, the stimulation of nicotinic acetylcholine receptors (nAChRs) leads to an antinociceptive effect. However, it remains to be elucidated which subtypes of nAChR are involved in the antino...

journal_title：Life sciences

authors： Abdin MJ,Morioka N,Morita K,Kitayama T,Kitayama S,Nakashima T,Dohi T

更新日期：2006-12-03 00:00:00

abstract：:The effects of leucine- and methionine-enkephalin, opiate peptides, on Ca2+ efflux from cultured bovine adrenal chromaffin cells were examined. These enkephalins stimulated the efflux of 45Ca2+ from cells in a concentration-dependent manner (10(-8) M-10(-6) M). Leucine-enkephalin did not increase the intracellular fre...

journal_title：Life sciences

authors： Umeda T,Azuma M,Houchi H,Ikehara T,Shono F,Yoshizumi M,Tamaki T,Minakuchi K

更新日期：1999-01-01 00:00:00

abstract：:Mycobacterium tuberculosis is the most successful pathogen with multiple mechanisms to subvert host immune response, resulting in insidious disease. There are few studies on whether the bacteria undergo antigenic variation in response to host immune pressure. Studies on T cell epitopes of M. tuberculosis can help us f...

journal_title：Life sciences

authors： Jiang Y,Liu H,Dou X,Zhao X,Li M,Li G,Bai Y,Zhang W,Lian L,Yu Q,Zhang J,Wan K

更新日期：2018-09-15 00:00:00

abstract：:We investigated the combined effect of 5-hydroxytryptamine (5-HT, serotonin) and calcium ionophore (A23187) on human platelet aggregation. Aggregation, monitored at 37 degrees C using a Dual-channel Lumi-aggregometer, was recorded for 5 min after challenge by a change in light transmission as a function of time. 5-HT ...

journal_title：Life sciences

authors： Connor JD,Rasheed H,Gilani AH,Cheema M,Rizvi Z,Saeed SA

更新日期：2001-10-26 00:00:00

abstract：:Experiments were undertaken to examine the characteristics of the adrenergic receptor-coupled cAMP system in rat brain slices. It was found that the potentiation of isoproterenol-stimulated cAMP accumulation by 6-fluoronorepinephrine, an alpha-adrenergic agonist, is largely dependent upon the degree of beta-receptor o...

journal_title：Life sciences

authors： Pilc A,Enna SJ

更新日期：1985-09-30 00:00:00

abstract：:Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated the efficacy in preventing soman...

journal_title：Life sciences

authors： Wang YA,Zhou WX,Li JX,Liu YQ,Yue YJ,Zheng JQ,Liu KL,Ruan JX

更新日期：2005-11-26 00:00:00

abstract：AIMS:The objective of this study was to establish a more accurate analytical model and method for grip strength test of mice and to investigate the beneficial effects of lifelong exercise training to prevent functional decline of muscle during aging. MAIN METHODS:Fifty randomly selected adult male BALB/c mice (24-56 w...

journal_title：Life sciences

authors： Zhao Y,Shen F,Gong M,Jin L,Ren X,Liu K,Lu J

更新日期：2020-06-15 00:00:00

abstract：AIMS:This study aimed to design and screen a dual functional fusion peptide that could penetrate the blood-brain barrier and target neuropilin 1 (NRP1) overexpressed in vascular endothelial cells for the anti-angiogenesis of glioma treatment. MAIN METHODS:At the cellular level, the in vitro anti-angiogenic activity of...

journal_title：Life sciences

authors： Zhao L,Chen H,Lu L,Zhao C,Malichewe CV,Wang L,Guo X,Zhang X

更新日期：2021-01-27 00:00:00

abstract：:Dihydroergosine (50 and 100 mg/kg) enhanced the incidence of bicuculline (3 mg/kg)-induced convulsions in female rats, while 100 mg/kg of dihydroergosine given to female mice made 45% convulsive dose of bicuculline (2.5 mg/kg) to be subconvulsive. The same dose of dihydroergosine enhanced in mice the latency of bicucu...

journal_title：Life sciences

authors： Pericić D,Tvrdeić A

更新日期：1990-01-01 00:00:00

abstract：:The effects of porcine uterine fluid filtrate (PUF) on lymphocyte activity were examined. PUF was added to porcine lymphocyte cultures in the presence or absence of phytohemagglutinin (PHA), concanavalin A (Con A), or pokeweed mitogen (PWM). Lymphocyte response was determined by 3H-thymidine incorporation. Results ind...

journal_title：Life sciences

authors： Li WI,Yang WC

更新日期：1993-01-01 00:00:00

abstract：:Plasma and urinary levels of MHPG were determined in six normal volunteers. Samples were obtained at 3-hour intervals for plasma and at 12-hour intervals for urine. Acrophase, amplitude and period were determined for plasma MHPG levels. A sinusoidal pattern was obtained for diurnal plasma MHPG with a peak at 15:00 hrs...

journal_title：Life sciences

authors： DeMet EM,Halaris AE,Gwirtsman HE,Reno RM

更新日期：1985-11-04 00:00:00

abstract：:Morning urine samples were assayed for human EGF (hEGF) in 137 non-insulin dependent diabetic patients with normal serum creatinine and beta 2-microglobulin levels. Serving as controls, 80 age- and sex-matched healthy subjects were also examined. A significant positive correlation between hEGF excretion and the level ...

journal_title：Life sciences

authors： Kawaguchi M,Kamiya Y,Ito J,Fujii T,Hayakawa F,Sakuma N,Fujinami T

更新日期：1993-01-01 00:00:00

abstract：:The effects of two benzodiazepine derivatives (diazepam, 0.5-1 mg/kg; alprazolam, 1.25-2.5 mg/kg) on ultrasonic calling elicited in adult rats by unavoidable aversive stimuli (footshocks) were investigated. The results show that either diazepam or alprazolam affected the duration of ultrasonic calls. In particular, a ...

journal_title：Life sciences

authors： Cuomo V,Cagiano R,De Salvia MA,Maselli MA,Renna G,Racagni G

更新日期：1988-01-01 00:00:00

abstract：:An improved two-dimensional HPTLC procedure was developed for separating phospholipids including individual phosphoinositides, phosphatidic acids and plasmalogens. This procedure was used to examine the time course for uptake of label by phospholipids in brain subcellular membranes after intracerebral injection of [ga...

journal_title：Life sciences

authors： Sun GY,Lin TN

更新日期：1989-01-01 00:00:00

abstract：AIMS:Ovarian cancer (OC) is the most lethal gynecologic malignant tumors all over the world. HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) has been reported as an important regulator in multiple tumors. However, the functions of HOTAIRM1 in OC and its possible molecular mechanisms remain unclear. MAIN METHODS:qRT-...

journal_title：Life sciences

authors： Chao H,Zhang M,Hou H,Zhang Z,Li N

更新日期：2020-02-15 00:00:00

abstract：:We observed a significant increase in plasma atrial natriuretic factor (ANF) in antiorthostatic hypokinetic suspension (AOH) rats after 2 h of suspension when the experiment was made during day. Plasma ANF was investigated in relation to renal glomerular ANF receptors during AOH at night. The aim of this study was 1) ...

journal_title：Life sciences

authors： Gauquelin G,Schiffrin EL,Garcia R,Entresangles M,Cantin M,Gharib C

更新日期：1988-01-01 00:00:00

abstract：:Three continuous cell lines isolated from small cell carcinoma of the lung (SCCL) have been examined for their ability to take up and metabolize the biogenic amine precursors, L-DOPA and 5-hydroxytryptophane (5-HTP). In two of the three lines formaldehyde-induced fluorescence (FIF) and mass-spectrographic analysis ind...

journal_title：Life sciences

authors： Pettengill OS,Bacopoulos NG,Sorenson GD

更新日期：1982-04-19 00:00:00

abstract：AIMS:Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition...

journal_title：Life sciences

authors： Fowlkes V,Clark J,Fix C,Law BA,Morales MO,Qiao X,Ako-Asare K,Goldsmith JG,Carver W,Murray DB,Goldsmith EC

更新日期：2013-03-28 00:00:00

abstract：:The effect of calcium (Ca2+) on the adenylate cyclase activity and calmodulin level of cerebral cortex was determined in pentobarbital dependent rats and age matched controls. Female Sprague-Dawley rats were made dependent and maintained on pentobarbital by eating a mixture of pentobarbital and rat chow (350 mg pentob...

journal_title：Life sciences

authors： Piascik MT,McNicholas LF

更新日期：1985-07-08 00:00:00

abstract：AIMS:To explore the carcinostatic effects of platinum nanocolloid (Pt-nc) combined with gamma rays on human esophageal squamous cell carcinoma (ESCC). MAIN METHODS:ESCC-derived KYSE-70 cells were treated with various concentrations of Pt-nc and/or gamma irradiation, and subsequently cultured in phenol red free DMEM wi...

journal_title：Life sciences

authors： Li Q,Tanaka Y,Saitoh Y,Tanaka H,Miwa N

更新日期：2015-04-15 00:00:00

abstract：:We evaluated the effect of several classes of calmodulin inhibitors on the activity of calmodulin prepared from C6 astrocytoma cells and studied the activity of these drugs as inhibitors of the growth of C6 cells in tissue culture. There was a good correlation between the activity of the drugs as inhibitors of calmodu...

journal_title：Life sciences

authors： Lee GL,Hait WN

更新日期：1985-01-28 00:00:00

abstract：:Hexokinase and glucose-6-phosphate dehydrogenase activities were studied in brain regions after intraventricular injection of kainic acid. Hexokinase activity was decreased by 10-15% in various regions while glucose-6-phosphate dehydrogenase activity remained unaltered. Soluble hexokinase activity, which remained the ...

journal_title：Life sciences

authors： Leong SF

更新日期：1991-01-01 00:00:00

abstract：:The effects of subcutaneous (sc) administration of estradiol (50 micrograms/100 microliters/day x 10 day) or testosterone (15 mg/100 microliters twice a week x 2 weeks) on ANF release were examined in isolated perfused rat atria. The concentration of ANF in the perfusate was measured by radioimmunoassay, under basal c...

journal_title：Life sciences

authors： Deng Y,Kaufman S

更新日期：1993-01-01 00:00:00

abstract：:The composition of various amino acids and related compounds in the aorta, ventricle, atria, liver, kidney, pancreas, bronchi and adrenals of rats is presented. These patterns are qualitatively similar, but quantitatively different. Stress changed these patterns. In the aorta, alpha-aminobutyric acid and ammonia are d...

journal_title：Life sciences

authors： Decker R,von Stuckrad-Barre S,Milakofsky L,Hofford JM,Harris N,Vogel WH

更新日期：1995-01-01 00:00:00

abstract：:Abdominal aortic coarctation above the renal arteries leads to severe hypertension above the stenotic site and provides a model for simultaneous testing of the effects of increased and decreased pressure and consequently shear stress in the same animal. The effects of increased pressure, per se, on oxidative stress an...

journal_title：Life sciences

authors： Sindhu RK,Roberts CK,Ehdaie A,Zhan CD,Vaziri ND

更新日期：2005-01-07 00:00:00

abstract：:Resveratrol, a polyphenolic phytoaxelin present in red wine, has been suggested to protect against atherosclerosis and cardiovascular disease because of its antioxidant effects. Intercellular adhesion molecule (ICAM-1), induced by cytokines, has been hypothesized to play a role in the early events during atheroscleros...

journal_title：Life sciences

authors： Wung BS,Hsu MC,Wu CC,Hsieh CW

更新日期：2005-12-12 00:00:00

abstract：AIMS:To investigate how Placental Mesenchymal Stem Cells (P-MSCs) would adapt themselves and survive under hypoxic conditions which are prevalent in most injury sites. MAIN METHODS:P-MSCs were isolated from term placenta and characterised under normoxia and hypoxia (2-2.5% O2). Cells were examined for morphology and s...

journal_title：Life sciences

authors： Mathew SA,Chandravanshi B,Bhonde R

更新日期：2017-08-01 00:00:00

abstract：:The abdominal subcutaneous interstitium is easily accessible for monitoring glucose for Diabetes Mellitus research and management. The available glucose sensing devices demand frequent blood sampling by finger pricking for calibration. Moreover, there is controversy about the exact relationship between the levels of g...

journal_title：Life sciences

authors： Tiessen RG,Rhemrev-Boom MM,Korf J

更新日期：2002-04-21 00:00:00

abstract：:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO...

journal_title：Life sciences

authors： Matsui M,Yamada S,Oki T,Manabe T,Taketo MM,Ehlert FJ

更新日期：2004-11-05 00:00:00

abstract：:Tramadol is a clinically-effective, centrally-acting analgesic. This drug is a racemic mixture of two enantiomers, each one displaying different mechanisms: (+)tramadol displays opioid agonist properties and inhibits serotonin reuptake while (-)tramadol inhibit preferentially noradrenaline reuptake. The action of tram...

journal_title：Life sciences

authors： Rojas-Corrales MO,Gibert-Rahola J,Micó JA

更新日期：1998-01-01 00:00:00