Abstract：
:The effects of leucine- and methionine-enkephalin, opiate peptides, on Ca2+ efflux from cultured bovine adrenal chromaffin cells were examined. These enkephalins stimulated the efflux of 45Ca2+ from cells in a concentration-dependent manner (10(-8) M-10(-6) M). Leucine-enkephalin did not increase the intracellular free Ca2+ level, 45Ca2+ uptake, catecholamine secretion, cAMP level or cGMP level. The peptide-stimulated 45Ca2+ efflux was not inhibited by incubation in Ca2+-free medium, but was inhibited by incubation in Na+-free medium. These results indicate that enkephalins stimulate extracellular Na+-dependent 45Ca2+ efflux from cultured bovine adrenal chromaffin cells, probably by stimulating membrane Na+/Ca2+ exchange.
journal_name
Life Scijournal_title
Life sciencesauthors
Umeda T,Azuma M,Houchi H,Ikehara T,Shono F,Yoshizumi M,Tamaki T,Minakuchi Kdoi
10.1016/s0024-3205(99)00493-2subject
Has Abstractpub_date
1999-01-01 00:00:00pages
PL247-52issue
21eissn
0024-3205issn
1879-0631pii
S0024320599004932journal_volume
65pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:In some cell systems muscarinic receptor stimulation can induce proliferation or transformation. This phenomenon is subtype-specific (only m1 and m3 receptors are effective) and cell type dependent. In 1321N1 astrocytoma cells activation of m3 receptors stimulates phospholipase C, but does not induce DNA synthesis. In...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:The relationship between prolactin (PRL) secretion and the neurointermediate lobe (NIL) of the pituitary gland was investigated. Plasma PRL concentrations in rats bearing anterior pituitaries autografted with or without the NIL to the renal capsule were elevated to equal extents at 1 through 6 weeks after surgery (p g...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90535-5
更新日期：1982-03-29 00:00:00
abstract：:Guinea pig ileum longitudinal muscle/myenteric plexus preparations contain functional mu- and kappa-opioid receptors. A preparation with blocked kappa receptors was obtained by pretreating guinea pigs with 0.1-10.0 mg/kg intraperitoneal doses of a new kappa-selective affinity label, DIPPA (2-(3,4-dichlorophenyl)-N-met...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00076-3
更新日期：1997-01-01 00:00:00
abstract：:Heat shock protein 70 (Hsp70) is capable of protecting cells, tissues, organs, and animals from a subsequent, normally lethal heating, as well as from numerous disease states. Therefore, it would be of great therapeutic benefit to discover compounds that are clinically safe yet able to induce Hsp70 in patients. Carben...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01362-5
更新日期：2001-11-02 00:00:00
abstract：:Nitrosamines are carcinogens formed in the mammalian organism from amine precursors contained in food, beverages, cosmetics and drugs. The potent carcinogen, NNK, and the weaker carcinogen, NNN, are nitrosamines formed from nicotine. Metabolites of the nitrosamines react with DNA to form adducts responsible for genoto...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2007.03.006
更新日期：2007-05-30 00:00:00
abstract：:PD 128907 [4a R, 10 b R-(+)-trans-3, 4, 4a, 10 b - tetrahydro - 4- n -propyl2 H,5H-[1]benzop-yrano[4,3-b]1,4-oxazin-9-ol.], a selective dopamine (DA) D3 receptor agonist ligand exhibits about a 1000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a 10000-fold selectivity ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02102-o
更新日期：1995-01-01 00:00:00
abstract：:Trichosanthin (TCS) is a type 1 ribosome-inactivating protein (RIP) effective against HIV-1 and HSV-1 replication. The mechanism of its antiviral activity is not clear. Many believe that it is related to ribosome inactivation. Some RIPs and viral infection affect the phosphorylation of MAPK and Bcl-2 and these protein...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.03.047
更新日期：2006-08-22 00:00:00
abstract：:This study investigated the protective effects of acteoside, a phenylethanoid glycoside, on the carbon tetrachloride-induced hepatotoxicity as well as the possible mechanisms involved in this protection in mice. Pretreatment with acteoside prior to the administration of carbon tetrachloride significantly prevented the...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.07.020
更新日期：2004-01-09 00:00:00
abstract：:The present study investigated the protective actions of the antioxidant scutellarin against the cytotoxicity produced by exposure to H2O2 in PC12 cells. This was done by assaying for MTT (3,(4,5-dimethylthiazole-2-yl)2,5-diphenyl-tetrazolium bromide) reduction and lactate dehydrogenase (LDH) release. Reactive oxygen ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.09.074
更新日期：2004-04-30 00:00:00
abstract：:The hypothalamic AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) pathway is known to play an important role in the control of food intake and energy expenditure. Here, we hypothesize that citrate, an intermediate metabolite, activates hypothalamic ACC and is involved in the control of energy mobilizat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.04.015
更新日期：2008-06-20 00:00:00
abstract：AIM:Diabetic nephropathy is the leading cause of end stage renal disease in developed countries throughout the world. The imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system is the main problem that is responsible for the progression of diabetic kidney disease. In this s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.04.018
更新日期：2015-08-15 00:00:00
abstract：:The influence of stressful experiences on the development of vacuous chewing movements (VCM) was investigated in non-medicated rats. After an initial baseline period one group of rats was housed in a noisy environment while another group was housed in quiet surroundings. The development of VCM was recorded during a 16...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90146-3
更新日期：1991-01-01 00:00:00
abstract：:The effects of delta 9-THC and other cannabinoids on cAMP levels in synaptosomes from mouse brains were investigated in order to determine whether cannabinoids produced their behavioral effects through alterations in adenylate cyclase. delta 9-THC (0.01-10 microM) did not significantly alter basal cAMP levels, whereas...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90450-p
更新日期：1991-01-01 00:00:00
abstract：:The actions of insulin-like growth factor I (IGF-I) and growth hormone (GH) on lipid metabolism have been investigated in hormonally intact rats. The subcutaneous injection of IGF-I (100 micrograms) and GH (100 micrograms) lowered total cholesterol plasma levels. The in vitro assays on isolated rat adipocytes showed a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02067-s
更新日期：1995-01-01 00:00:00
abstract：AIMS:Short-chain acyl-CoA dehydrogenase (SCAD) is a key enzyme in fatty acid oxidation. In the present study we aim to investigate the changes in SCAD between pathological and physiological cardiomyocyte hypertrophy. We also explore the different signaling pathways of pathological and physiological cardiomyocyte hypert...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.01.015
更新日期：2015-03-01 00:00:00
abstract：:Dihydroergosine (50 and 100 mg/kg) enhanced the incidence of bicuculline (3 mg/kg)-induced convulsions in female rats, while 100 mg/kg of dihydroergosine given to female mice made 45% convulsive dose of bicuculline (2.5 mg/kg) to be subconvulsive. The same dose of dihydroergosine enhanced in mice the latency of bicucu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90608-t
更新日期：1990-01-01 00:00:00
abstract：:Purification of endothelin converting enzyme (ECE) from endothelial cells has been hindered by the difficulty in obtaining primary endothelial cells in large quantity. We therefore tested transformed human umbilical vein endothelial cells (EA.hy926) for ECE activity. Our data clearly demonstrate that this transformed ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00227-w
更新日期：1995-01-01 00:00:00
abstract：:Cocaine cues elicit craving and physiological responses. The cerebral circuits involved in these are poorly understood. The purpose of this study was to assess the relation between regional brain activation and cocaine cue elicited responses. Thirteen right-handed cocaine abusers were scanned with positron emission to...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00619-5
更新日期：1999-01-01 00:00:00
abstract：:To evaluate the relative contributions of the ovarian inhibin and estradiol-17 beta (E) on the regulation of FSH secretion, inhibin and E in ovarian venous plasma (OVP) and FSH and LH in peripheral plasma were simultaneously measured using superovulating rats with special reference to follicular maturation. By the tra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90445-5
更新日期：1986-07-14 00:00:00
abstract：:The experiments were designed to study whether the inhibitors of the uptake of serotonin (5-HT) potentiated the prejunctional effects of 5-HT on peripheral sympathetic nerves. The effect of two selective 5-HT uptake inhibitors, citalopram and fluoxetine, were studied on the presynaptic actions of 5-HT in the cat isola...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90438-8
更新日期：1986-07-07 00:00:00
abstract：:Silica (SiO2) nanoparticles (NPs) were synthesized by laser ablation method and were characterized by TEM and DLS techniques. Afterwards, their inhibition activity against carbonic anhydrase (CA) isoforms (CA I and CA II) was explored by experimental and theoretical analysis. Also, the protective effect of SiO2 NPs ag...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2021.119032
更新日期：2021-01-12 00:00:00
abstract：:Neem seed preparations contain not only azadirachtin as the active insect antifeedant or growth regulator but also a variety of their limonoids, some of which are cytotoxic to N1E-115 neuroblastoma (mouse), 143B.TK- osteosarcoma (human) and Sf9 (insect) cultured cell lines. The most potent of these limonoids is nimbol...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00061-6
更新日期：1996-01-01 00:00:00
abstract：:Previously we have reported a decreased GABAB receptor expression in brain of spontaneously hepertensive rats (SHR). Moreover, decreased receptor numbers were accompanied by depressed stimulation of cAMP formation. We have now quantified Gi alpha protein by immunoblotting in cerebral membranes from 11-week-old normote...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00573-5
更新日期：1996-01-01 00:00:00
abstract：:In the present work we have investigated to what extent somatostatin (SRIF) release from median eminence (ME) is affected by stress immobilization (IMO) in unanesthetized rats stereotaxically implanted with a push-pull cannula (PPC). One week after implantation, the ME was perfused with artificial cerebrospinal fluid ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90149-w
更新日期：1993-01-01 00:00:00
abstract：:YM-09151-2(cis-N-(1-benzyl-2-methylpyrrolidin-3-yl) -5-chloro-2-methoxy-4-methylaminobenzamide) is a new benzamide which has been reported to be an antagonist of dopamine (DA) at D1-type DA receptors. In the present study, we have examined the extent of the interaction of YM-09151-2 with D2-type DA receptors in the an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90933-5
更新日期：1983-02-28 00:00:00
abstract：:The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.05.043
更新日期：2016-07-15 00:00:00
abstract：:Alzheimer's disease (AD) involves selective loss of muscarinic m2, but not m1, subtype neuroreceptors in the posterior parietal cortex of the human brain. Emission tomographic study of the loss of m2 receptors in AD is limited by the fact that there is currently no available m2-selective radioligand which can penetrat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90161-u
更新日期：1993-01-01 00:00:00
abstract：:The effects of aporphines and secoaporphines on glucose uptake by isolated intestinal brush-border membrane vesicles (BBMV) or basolateral membrane vesicles (BLMV) and glucose absorption during in situ intestinal perfusion were studied. Of the tested compounds, N-allylsecoboldine was the most potent glucose uptake inh...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.12.031
更新日期：2006-06-06 00:00:00
abstract：AIMS:We have shown that diabetes causes cerebrovascular remodeling in part by the activation of the endothelin (ET-1) system in a glucose-dependent manner. We also reported increased yet dysfunctional cerebral angiogenesis in diabetes. Here, we tested the hypothesis that dual ET-1 receptor antagonism or glycemic contro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.01.008
更新日期：2014-11-24 00:00:00
abstract：:Acute myocardial infarction (AMI) is associated with inflammation and apoptosis. Emodin plays an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that emodin protects against myocardial ischemia/reperfusion injury. However, its mechanism underlying its effects remains unknown. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.08.040
更新日期：2007-10-13 00:00:00
