Abstract：
AIMS:In this study, we investigated the effects of Bax-inhibiting peptide (Bip)-V5, an anti-apoptosis membrane-permeable peptide, on the 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) model rats. MATERIALS AND METHODS:Rats were randomly divided into five groups: Control, 6-OHDA only, Vehicle+6-OHDA, zVAD+6-OHDA, and V5+6-OHDA, that rats were preadministrated with different reagents before 6-OHDA administration. KEY FINDINGS:The result showed that intrastriatal preadministration of Bip-V5 significantly decreased the amphetamine-induced rotation of the 6-OHDA model rats and the loss of the nigral dopaminergic (DA) neurons. Moreover, Bip-V5 intrastriatal preadministration not only significantly decreased the expression of activated caspase 9 and activated caspase 3 but also decreased the enhanced expression of AIF and its nuclear translocation in the SNpc. The results in our study provide the first experimental evidence that both caspase-dependent and AIF-dependent apoptosis pathways are involved in the loss of the nigral DA neurons caused by intrastriatal administration of 6-OHDA, and intrastriatal preadministration of Bip-V5 can inhibit the above two apoptosis pathways to protect the nigral DA neurons. SIGNIFICANCE:Our results provide a new idea that Bax-inhibiting peptide may be a promising preventive or therapeutic method for PD.
journal_name
Life Scijournal_title
Life sciencesauthors
Ma C,Pan Y,Yang Z,Meng Z,Sun R,Wang T,Fei Y,Fan Wdoi
10.1016/j.lfs.2015.11.019subject
Has Abstractpub_date
2016-01-01 00:00:00pages
113-20eissn
0024-3205issn
1879-0631pii
S0024-3205(15)30082-5journal_volume
144pub_type
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