Abstract：
:Leu-enkephalin (100 micrograms/kg, i.p.) administered to mice 5 min before training in a one way active avoidance task significantly reduced the number of avoidances observed in the peptide treated animals. This impairing action of Leu-enkephalin was partially attenuated by methylnaloxonium (naloxonium), a quarternary form of naloxone with a limited ability to penetrate the blood brain barrier. Passive immunization (i.v.) of mice with a Leu-enkephalin antiserum 4 hrs before training produced an effect on avoidance conditioning that was the opposite to that observed with Leu-enkephalin alone. That is, passive immunization increased the number of avoidances observed in the treated mice. The results suggest that Leu-enkephalin actions on avoidance conditioning are mediated by a peripheral opioid mechanism, that leu-enkephalin may have a primary site of action outside the blood brain barrier, and that peripheral Leu-enkephalin systems may normally operate to influence conditioned avoidance behavior.
journal_name
Life Scijournal_title
Life sciencesauthors
Martinez JL Jr,de Graaf JS,Chavkin C,Dana RCdoi
10.1016/0024-3205(85)90101-8subject
Has Abstractpub_date
1985-12-23 00:00:00pages
2345-53issue
25eissn
0024-3205issn
1879-0631pii
0024-3205(85)90101-8journal_volume
37pub_type
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