Abstract:
:Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with emphasis on its role against pathological oxidative stress including hemoglobin-mediated free radical reactions. Male wistar rats were grouped as normal control, streptozotocin-induced diabetic control, normal treated with pelargonidin and diabetic treated with pelargonidin. Pelargonidin-treated rats received one time i.p injection of the flavonoid (3 mg/kg bodyweight). Biochemical parameters were assayed in blood samples of different groups of rats. Liver was used for histological examinations. Pelargonidin treatment normalized elevated blood glucose levels and improved serum insulin levels in diabetic rats. Glucose tolerance test appeared normal after treatment. Decreased serum levels of SOD and catalase, and increased levels of malondialdehyde and fructosamine in diabetic rats were reverted to their respective normal values after pelargonidin administration. Extents of hemoglobin glycation, hemoglobin-mediated iron release, iron-mediated free radical reactions and carbonyl formation in hemoglobin were pronounced in diabetic rats, indicating association between hemoglobin glycation and oxidative stress in diabetes. Pelargonidin counteracts hemoglobin glycation, iron release from the heme protein and iron-mediated oxidative damages, confirming glycated hemoglobin-associated oxidative stress in diabetes.
journal_name
Life Scijournal_title
Life sciencesauthors
Roy M,Sen S,Chakraborti ASdoi
10.1016/j.lfs.2008.03.011subject
Has Abstractpub_date
2008-05-23 00:00:00pages
1102-10issue
21-22eissn
0024-3205issn
1879-0631pii
S0024-3205(08)00135-5journal_volume
82pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::The association between various parameters of acute and chronic smoking status and plasma levels of three proteins, C9, C1-inhibitor (C1-INH) and alpha 1-protease inhibitor (alpha 1-PI) were determined for 49 male cigarette smokers and 49 age-matched nonsmokers (mean age = 32.2 years). The mean number of cigarettes sm...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90391-1
更新日期:1985-03-11 00:00:00
abstract::In this paper, we describe the characterization of the expression of monoamine oxidase (MAO) in whole pancreas and in isolated islets of Langerhans from human. Classical monamine oxidase activity assays reveal that both isoforms A & B are present in human pancreas. Two complementary approaches indicated that both MAO ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00265-9
更新日期:1999-01-01 00:00:00
abstract::P75(NTR) is a common neurotrophin receptor which binds all neurotrophins with similar affinities and has been shown to be capable of mediating programmed cell death. In this study, we investigated effects of the antipsychotic drugs (APDs) haloperidol, clozapine, quetiapine, and risperidone on p75(NTR) mRNA levels in P...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.01.039
更新日期:2006-07-04 00:00:00
abstract::Mechanisms by which opiates alter neuronal functions, including neuroendocrine functions, are not well defined. We have previously demonstrated that morphine rapidly and transiently increases expression of the proto-oncogene c-fos in the rat caudate-putamen. This regulation of the c-fos gene by morphine may represent ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90233-h
更新日期:1990-01-01 00:00:00
abstract:AIMS:Exposure to glucose and its metabolites in peritoneal dialysis fluid (PDF) results in structural alterations of the peritoneal membrane. Icodextrin-containing PDF eliminates glucose and reduces deterioration of peritoneal membrane function, but direct effects of icodextrin molecules on peritoneal mesothelial cells...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.04.036
更新日期:2012-06-14 00:00:00
abstract::Anandamide (arachidonylethanolamide), isolated from porcine brain, has been shown to bind to the cannabinoid receptor and also to produce cannabimimetic activity in pharmacological assays. This study examined structure-activity relationships in alkylated anandamide analogs. The analogs were evaluated for their ability...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00187-b
更新日期:1995-01-01 00:00:00
abstract::The effect of cadmium (Cd2+) was studied in vitro on the flavokinase (ATP : riboflavin 5'-phosphotransferase, EC 2.7.1.26) activity purified from rat liver. Cadmium inhibited flavokinase activity in a concentration-dependent manner and the effect was completely reversed by increasing concentration of zinc (Zn2+), indi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00151-3
更新日期:1997-01-01 00:00:00
abstract::The anthropogenic chemicals nonylphenol, bisphenol A, phthalic acid benzyl n-butyl ester, phthalic acid di-n-butyl ester and phthalic acid di(2-ethylhexyl) ester have been shown to possess sex hormone-like activity. To explore the possible actions of these chemicals on the autacoid synthesis in the body, we investigat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01538-7
更新日期:2002-03-29 00:00:00
abstract::We investigated the role of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) in hemodynamic action of leptin. The effect of leptin (1 mg/kg i.p.) on systolic blood pressure (SBP) was examined in lean rats and in rats made obese by feeding highly palatable diet for either 1 or 3 months. Separate ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.12.041
更新日期:2006-05-30 00:00:00
abstract::Differences in prevalence and mortality from coronary artery disease (CAD) were observed among the different Israeli ethnic groups. The incidence of CAD in Israel is highest among Ashkenazi Jews and is much lower among Yemenite Jews. In this present study, we selected 15 single nucleotide polymorphisms (SNPs) from 14 ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.02.012
更新日期:2004-07-09 00:00:00
abstract::Several different vasodilator substances can be released by vascular endothelium in response to mechanical stimuli and vasoactive agents. The purpose of this study was to determine whether there is a male-female difference in the relative contributions of nitric oxide (NO) and endothelium-derived hyperpolarizing facto...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01851-9
更新日期:2002-08-23 00:00:00
abstract:AIMS:Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.02.035
更新日期:2019-03-15 00:00:00
abstract:AIMS:The mechanisms underlying the fetal origin of renal disease remains unknown. This study aimed to investigate the profiles of ion channel and transporter proteins in the fetal kidney in fetal growth restriction (FGR)rats, and to explore their association with the fetal origin of renal disease. MAIN METHODS:An FGR ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118276
更新日期:2020-10-15 00:00:00
abstract::Cardiovascular risk factors associated with hypertension include alterations in arterial compliance and an increased tendency to thrombosis. In this study we examined the relationship between arterial compliance and endothelial derived components of the hemostatic system: von Willebrand factor (vWF) and tissue plasmin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90192-6
更新日期:1993-01-01 00:00:00
abstract::Although nitrosation plays an important role in initiation of carcinogenesis, the reactive nitrogen oxygen species (RNOS) mediating this reaction by multiple pathways have not been determined. The heterocyclic amine carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was used as a target to investigate RNOS and pa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.10.010
更新日期:2007-01-23 00:00:00
abstract::Elevated total homocysteine concentrations and obesity are both associated with an increased risk of cardiovascular disease. However, previous studies of weight reduction on serum homocysteine concentrations have obtained inconsistent reports. We investigated the effect of folic acid supplementation on serum homocyste...
journal_title:Life sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.lfs.2004.12.002
更新日期:2005-03-18 00:00:00
abstract::Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. The iNOS and COX-2 proteins and their mRNA expressions in cultured vascul...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01464-3
更新日期:2002-01-11 00:00:00
abstract::Circadian rhythms might be involved in addictive behaviors. The pineal secretory product melatonin decreases cocaine sensitization in rats; mice mutant for the critical melatonin-synthesizing enzyme, arylalkylamine N-acetyltransferase (AANAT), exhibit altered behaviors. We hypothesized that AANAT/melatonin system, whi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01559-x
更新日期:2002-05-10 00:00:00
abstract:AIMS:The objectives of this study were to determine the cytokine induction by delta tocotrienol (DT3, a promising radiation countermeasure) and to investigate the role of granulocyte colony-stimulating factor (G-CSF) in its radioprotective efficacy against ionizing radiation in mice. MAIN METHODS:Multiplex Luminex was...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.01.065
更新日期:2014-03-11 00:00:00
abstract::Despite reductions in beta-adrenoreceptor (beta-AR)-mediated inotropic effects induced by sustained sympathetic activation in cardiac disease, whether these changes necessarily result in reductions in systolic function under resting conditions (baseline function) is not clear. Moreover, possible compensatory mechanism...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.04.047
更新日期:2005-12-12 00:00:00
abstract::Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90198-x
更新日期:1984-02-27 00:00:00
abstract::The distribution pattern of ascorbic acid in the endocrine organs and/or tissues was investigated during various sexual states of female rats to demonstrate a correlation between ascorbic acid concentration and sex hormone activity. The concentration of ascorbic acid was estimated in the plasma, liver, pancreas, thyro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90111-f
更新日期:1993-01-01 00:00:00
abstract::The analgesic effects of low current transcranial electrostimulation are both naloxone and pCPA-reversible, suggesting that they may be mediated in part by endogenous opioid and serotonergic activity. The present experiments indicate that pretreatment with the serotonin precursor L-tryptophan results in an increased a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90583-d
更新日期:1990-01-01 00:00:00
abstract::The effects of nineteen AHPA* derivatives were examined on morphine analgesia by tail-flick test in rats and on enkephalinase inhibition which was based on the formation of tyrosyl-glycyl-glycine from met-enkephalin. The correlation between the enhancement of morphine analgesia in vivo and enkephalinase inhibition in ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90308-3
更新日期:1982-05-17 00:00:00
abstract::The complexes of the type [PtCl(L2)(ACRAMTU)](NO3)2 (ACRAMTU = 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea) were synthesized: PT-ACRAMTU (1), L2 = ethane-1,2-diamine (en); PT(dach)-ACRAMTU (2), L2 = (1R,2R)-1,2-diaminocyclohexane (dach); PT(pda-OH)-ACRAMTU (3), L2 = 2-hydroxy-1,3-propanediamine (pda-OH). The c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.11.052
更新日期:2019-01-15 00:00:00
abstract::The analgesic buprenorphine hydrochloride (Bph) induced apoptosis-like cell death in the caspase-3-deficient human breast cancer cell line, MCF-7. This apoptosis-like cell death activated key molecules in the mitochondrial apoptotic pathway: cytochrome c, caspase-9, caspase-7, and caspase-6. Bph caused the release of ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.11.032
更新日期:2004-06-04 00:00:00
abstract::Striatal D-2 dopamine (DA) antagonist and agonist binding sites were measured during the rat estrous cycle and compared to ovariectomized (OVX) rats. Dopaminergic D-2 antagonist binding sites were constant during the estrous cycle while agonist binding sites show a rapid and significant decrease of the ratio of high t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90137-3
更新日期:1988-01-01 00:00:00
abstract::Amyloid beta-protein (A beta), the major protein of cerebrovascular and plaque amyloid in Alzheimer disease, is considered a primary factor in the pathology of this disease. The effect of synthetic A beta (1-40) on the activity of protein kinase C (PKC) was studied with histones for a substrate in a mixed micellar ass...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90328-9
更新日期:1991-01-01 00:00:00
abstract::Glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells (RBCs) are known to be more susceptible to oxidant-induced hemolysis. Erythrocytes from G6PD-deficient individuals are significantly more susceptible to Ca(2+)-induced vesiculation than normal control cells. The enhanced susceptibility of G6PD-deficien...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00377-3
更新日期:1996-01-01 00:00:00
abstract::The actions of insulin-like growth factor I (IGF-I) and growth hormone (GH) on lipid metabolism have been investigated in hormonally intact rats. The subcutaneous injection of IGF-I (100 micrograms) and GH (100 micrograms) lowered total cholesterol plasma levels. The in vitro assays on isolated rat adipocytes showed a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02067-s
更新日期:1995-01-01 00:00:00