Augmented analgesic effects of L-tryptophan combined with low current transcranial electrostimulation.

abstract：AIMS:The type 2 muscarinic receptor (M2R) differs from the other G-protein-coupled muscarinic receptor (type 4, or M4R) in tissue distribution and physiologic effects. We studied the impact of these receptors on sleep and arousal by using M2R and M4R knock-out (KO) mice. MAIN METHODS:M2R and M4R KO and genetically int...

journal_title：Life sciences

authors： Turner J,Hughes LF,Toth LA

更新日期：2010-01-30 00:00:00

abstract：:The stability of epidermal growth factor (EGF) in the gastrointestinal humen of 3-day-old suckling and 45-day-old weaned pigs was examined by incubating iodine labeled recombinant human EGF (hEGF) in the gastrointestinal fluids at 37 degrees C and monitoring the generation of acid soluble radioactivity. Chromatographi...

journal_title：Life sciences

authors： Shen WH,Xu RJ

更新日期：1996-01-01 00:00:00

abstract：:Cloned human MCF-7 breast tumor cells were prevented from proliferating when grown in charcoal-dextran stripped human female serum (CDFHS)-supplemented media (40% and 10%); this inhibition was maximally cancelled by estradiol-17, cisTamoxifen, and Metabolite E, whereas Tamoxifen, N-desmethylTamoxifen and Metabolite Y ...

journal_title：Life sciences

authors： Sonnenschein C,Papendorp JT,Soto AM

更新日期：1985-07-29 00:00:00

abstract：:It has been suggested that the myocardial production of nitric oxide, as a consequence of expression of the inducible isoform of nitric oxide synthase (NOS), plays an important role in the pathophysiology of heart failure. We determined the net cardiac production of nitrogen oxides (NOx), as a measure of NOS activity,...

journal_title：Life sciences

authors： Kaye DM,Chin-Dusting J,Esler MD,Jennings GL

更新日期：1998-01-01 00:00:00

abstract：:Chronic social defeat stress (CSDS) is an ethologically relevant psychosocial stress animal model and has been widely used in depression studies. Ginsenoside Rg1 (Rg1) is the major active ingredients of ginseng with low toxicity and neuroprotective effects. The present study aims to investigate the antidepressant effe...

journal_title：Life sciences

authors： Jiang N,Lv J,Wang H,Huang H,Wang Q,Lu C,Zeng G,Liu XM

更新日期：2020-07-01 00:00:00

abstract：:The effects of (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin of tea, on Ca(2+)-permeable non-selective cation currents (NSCC) and voltage-operated Ca(2+) channels (VOCC) have been investigated in cultured rat aortic smooth muscle cells using the whole-cell voltage-clamp technique. Under the Cs(+)/t...

journal_title：Life sciences

authors： Campos-Toimil M,Orallo F

更新日期：2007-05-16 00:00:00

abstract：:We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (M...

journal_title：Life sciences

authors： Atarashi K,Matsuoka H,Takagi M,Sugimoto T

更新日期：1989-01-01 00:00:00

abstract：:Leptin-deficient Ob/Ob mice are hypometabolic and have reduced fat cell expression of beta-3 adrenoceptors (ARs). To determine whether leptin repletion restores beta-3 AR number, C57BL/6J Ob/Ob mice were given exogenous leptin (5 mg/kg I.P. daily) for 21 days. Leptin administration reduced body weight from 43.1+/-3.7 ...

journal_title：Life sciences

authors： Breslow MJ,An Y,Berkowitz DE

更新日期：1997-01-01 00:00:00

abstract：:The effects of chronic treatment with antidepressants, verapamil, or lithium on serotonin (5-HT)-induced Ca2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy. Clomipramine and citalopram, at a concentration of 100 nM, decreased the peak values of 5-HT-induced [Ca2+]i changes. V...

journal_title：Life sciences

authors： Yamaji T,Kagaya A,Uchitomi Y,Yokota N,Yamawaki S

更新日期：1997-01-01 00:00:00

abstract：:The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...

journal_title：Life sciences

authors： Zhao Q,Mao A,Yan J,Si J,Zhou R,Gan L,Liu Y,Zhang H

更新日期：2016-07-15 00:00:00

abstract：:In a partially depolarized guinea pig papillary muscle preparation, BAY K8644 stimulated voltage-operated calcium channels, promoting slow action potentials; this effect was dose-dependent over a concentration range of 3 X 10(-7) M to 3 X 10(-6) M. Isoproterenol and histamine also induced slow action potentials by sti...

journal_title：Life sciences

authors： Mestre M,Carriot T,Néliat G,Uzan A,Renault C,Dubroeucq MC,Guérémy C,Doble A,Le Fur G

更新日期：1986-07-28 00:00:00

abstract：:Exposure of rats to an acute, uncontrollable stressor can increase brain norepinephrine (NE) turnover and decrease locomotor and exploratory behavior. We examined the ability of exogenous tyrosine, NE's amino acid precursor, to protect rats from developing these neurochemical and behavioral changes when stressed. Anim...

journal_title：Life sciences

authors： Reinstein DK,Lehnert H,Scott NA,Wurtman RJ

更新日期：1984-06-04 00:00:00

abstract：:The impact of exposure to lead on gut cytokine gene expression and oral tolerance was analyzed. Oral tolerization with ovalbumin (OVA) increased levels of IL-10 and TGF-beta in gut tissue while IFN-gamma mRNA levels remained unchanged in both autoimmune diabetes prone NOD and normal C57BL/6 mice. This shift towards Th...

journal_title：Life sciences

authors： Goebel C,Kirchhoff K,Wasmuth H,Flohé S,Elliott RB,Kolb H

更新日期：1999-01-01 00:00:00

abstract：:Contractile responses to norepinephrine (NE), and the population of beta-adrenoceptors, were determined in gastric fundus smooth muscle from rats with diabetes induced by streptozotocin (STZ), and age-matched controls. Relaxation and/or contraction of fundus strips of controls and diabetics were induced by 10(-5)M NE....

journal_title：Life sciences

authors： Sakai Y,Inazu M,Aihara K,Inoue K,Homma I

更新日期：1991-01-01 00:00:00

abstract：:Significant labelled dopamine uptake was evident in bone marrow, spleen and lymph nodes of normal murine hosts in vivo. On the contrary animals bearing solid Ehrlich carcinoma, 3H-dopamine uptake was significantly reduced. The tumor tissue itself incorporated only insignificant amount of dopamine. Bone marrow cells, s...

journal_title：Life sciences

authors： Basu S,Dasgupta PS,Lahiri T,Chowdhury JR

更新日期：1993-01-01 00:00:00

abstract：:Amino acid and reduced glutathione (GSH) levels in substantia nigra (SN) as well as striatal monoamine levels were measured in acetyl-L-carnitine (ALCar) treated and control Swiss-Webster mice. ALCar, L carnitine, or saline were administered i.p. to mice for 5 days and mice were decapitated 24 hours following the last...

journal_title：Life sciences

authors： Fariello RG,Ferraro TN,Golden GT,DeMattei M

更新日期：1988-01-01 00:00:00

abstract：:The hypothalamic AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) pathway is known to play an important role in the control of food intake and energy expenditure. Here, we hypothesize that citrate, an intermediate metabolite, activates hypothalamic ACC and is involved in the control of energy mobilizat...

journal_title：Life sciences

authors： Cesquini M,Stoppa GR,Prada PO,Torsoni AS,Romanatto T,Souza A,Saad MJ,Velloso LA,Torsoni MA

更新日期：2008-06-20 00:00:00

abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells (RBCs) are known to be more susceptible to oxidant-induced hemolysis. Erythrocytes from G6PD-deficient individuals are significantly more susceptible to Ca(2+)-induced vesiculation than normal control cells. The enhanced susceptibility of G6PD-deficien...

journal_title：Life sciences

authors： Tsai KJ,Shih LY,Hung IJ,Huang SW,Wei JS,Liu TZ,Chiu DT

更新日期：1996-01-01 00:00:00

abstract：AIMS:To explore the carcinostatic effects of platinum nanocolloid (Pt-nc) combined with gamma rays on human esophageal squamous cell carcinoma (ESCC). MAIN METHODS:ESCC-derived KYSE-70 cells were treated with various concentrations of Pt-nc and/or gamma irradiation, and subsequently cultured in phenol red free DMEM wi...

journal_title：Life sciences

authors： Li Q,Tanaka Y,Saitoh Y,Tanaka H,Miwa N

更新日期：2015-04-15 00:00:00

abstract：:To understand whether chronic inflammation alters the development of morphine tolerance, the tail-flick test was used to evaluate the analgesic effect of morphine (75 mg tablet, s.c.) in the arthritic rats at the day 9-12 after the inoculation with Freund's adjuvant. Spinal cord monoamines and amino acid neurotransmit...

journal_title：Life sciences

authors： Li JY,Wong CH,Huang KS,Liang KW,Lin MY,Tan PP,Chen JC

更新日期：1999-01-01 00:00:00

abstract：:Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val, melanin concentrating hormone (MCH), is a cyclic hormone possessing both MCH-like (melanin granule aggregating effect) and melanocyte stimulating hormone (MSH)-like (melanin granule dispersing effect) activities. Nine ring-contracted analogues were s...

journal_title：Life sciences

authors： Lebl M,Hruby VJ,Castrucci AM,Hadley ME

更新日期：1989-01-01 00:00:00

abstract：:Visual evoked responses (VER) to counterphased gratings were recorded from area 17 of cat visual cortex prior to and following administration of diisopropylfluorophosphate (DFP). The VER and acetylcholinesterase (AChE) activity of blood, retina, and visual cortex were reduced significantly following DFP administration...

journal_title：Life sciences

authors： Kirby AW,Harding TH,Wiley RW

更新日期：1987-12-14 00:00:00

abstract：:Three cholecystokinin type B (CCKB) receptor antagonists were labelled with 11C and evaluated ex vivo in rat biodistribution studies. The CCKB antagonists were YF 476 and two other compounds of the basic 3-ureido-1,4-benzodiazepine class. Following tail-vein administration of [11C]-YF 476 exceedingly low levels of rad...

journal_title：Life sciences

authors： Wilson AA,Jin L,Garcia A,DaSilva JN,Houle S

更新日期：2001-02-02 00:00:00

abstract：:Infusion of oxytocin (OT) into normal dogs, in doses which produced plasma levels of OT in the physiological range, has been shown to increase plasma levels of glucose, insulin and glucagon and increase rates of glucose production and uptake. This study sought to determine whether there was a correlation between these...

journal_title：Life sciences

authors： Altszuler N,Rosenberg CR,Winkler B,Fuchs AR,Hill PS,Hruby VJ

更新日期：1992-01-01 00:00:00

abstract：:The binding of 3H-ouabain to human erythrocytes was analyzed in a population of hospitalized male ethanol addicted patients under long term digitalis treatment. In the non-alcoholic patient group the long term digitalis treatment induced an increase in Bmax and Kd values; such modification was not observed in the alco...

journal_title：Life sciences

authors： Battaini F,Govoni S,Mauri A,Civelli L,Trabucchi M

更新日期：1987-06-29 00:00:00

abstract：:Although exposure to broad band (0.2-20 MHz) electromagnetic fields (EMF) is part of the treatment of several diseases, little is known as to their effects on myocardial protein expression and resistance to ischemia-reperfusion (I/R). We exposed Sprague-Dawley rats to either high (H, 10 min/day at 200 V/m, 36.1 microT...

journal_title：Life sciences

authors： Ronchi R,Marano L,Braidotti P,Bianciardi P,Calamia M,Fiorentini C,Samaja M

更新日期：2004-09-03 00:00:00

abstract：AIMS:Endoplasmic reticulum stress (ERS) as an emerging factor is involved in insulin resistance (IR), which is the pathological basis of diabetes mellitus. Accumulation of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase is associated with IR, but the underlying mechanisms have not b...

journal_title：Life sciences

authors： Qiu N,Wei XM,Zhang ZJ,He YL,Zhou XK,Xiong Y

更新日期：2020-11-01 00:00:00

abstract：:Hyperforin is the major active ingredient of Hypericum perforatum (St John's Wort), a traditional antidepressant medication. This study evaluated its inhibitory effects on the synaptic uptake of monoamines in rat forebrain homogenates, comparing the nature of the inhibition at synaptic and vesicular monoamine transpor...

journal_title：Life sciences

authors： Roz N,Mazur Y,Hirshfeld A,Rehavi M

更新日期：2002-09-27 00:00:00

abstract：:Protein tyrosine phosphorylation is prevalent throughout the nervous system. It has been implicated to play an important role in the development and maintenance of neuronal functions. In the past few years significant advances have been made in our understanding of the molecular mechanisms of synapse formation and syn...

journal_title：Life sciences

authors： Mei L,Si J

更新日期：1995-01-01 00:00:00

abstract：:Drug-induced refractoriness of alpha-adrenergic receptor-mediated vasoconstriction may be a clinically important phenomenon. We have investigated the possible molecular mechanisms underlying this phenomenon in cultured vascular smooth muscle cells derived from the rabbit aorta. alpha 1-Adrenergic receptors were identi...

journal_title：Life sciences

authors： Wikberg JE,Akers M,Caron MG,Hagen PO

更新日期：1983-10-03 00:00:00