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Apoptosis-like cell death of human breast cancer cell line MCF-7 induced by buprenorphine hydrochloride.

Abstract：

:The analgesic buprenorphine hydrochloride (Bph) induced apoptosis-like cell death in the caspase-3-deficient human breast cancer cell line, MCF-7. This apoptosis-like cell death activated key molecules in the mitochondrial apoptotic pathway: cytochrome c, caspase-9, caspase-7, and caspase-6. Bph caused the release of fluorescent protein from the mitochondria of MCF-7 cells transfected with the pDsRed2-Mito-vector in a time-dependent manner, suggesting disruption of the mitochondrial membrane. Zn(2+) as high as 2 mM did not inhibit the DNase that took part in this apoptosis. Thus, this unidentified DNase might resemble other DNases involved in apoptosis-like cell death whose activity is not inhibited by zinc ion.

journal_name

Life Sci

journal_title

Life sciences

authors

Kugawa F,Matsumoto K,Aoki M

doi

10.1016/j.lfs.2003.11.032

subject

Has Abstract

pub_date

2004-06-04 00:00:00

pages

287-99

issue

3

eissn

0024-3205

issn

1879-0631

pii

S0024320504002632

journal_volume

75

pub_type

杂志文章

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