Abstract：
:The flavonoid quercetin exhibited a biphasic effect on calcium and phospholipid-dependent protein kinase (protein kinase C) activity from rat brain and pig thyroid. At a low concentration (10(-7) M) quercetin stimulated the enzyme activity whereas at higher concentrations quercetin was inhibitory. By contrast the synthetic penta-0-ethylquercetin stimulated protein kinase C activity in a dose-dependent manner. When fresly dispersed pig thyroid cells were treated with penta-0-ethylquercetin or 12-0-tetradecanoylphorbol 13-acetate (TPA), a 50% decrease of the cytosolic protein kinase C activity was observed. These results suggest that the lipophilicity as well as other structural determinants may be crucial for the ability of flavonoids to regulate (inhibit or activate) the enzyme activity.
journal_name
Life Scijournal_title
Life sciencesauthors
Picq M,Dubois M,Munari-Silem Y,Prigent AF,Pacheco Hdoi
10.1016/0024-3205(89)90450-5subject
Has Abstractpub_date
1989-01-01 00:00:00pages
1563-71issue
21eissn
0024-3205issn
1879-0631pii
0024-3205(89)90450-5journal_volume
44pub_type
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