Abstract：
:We examined a hypothesis that alpha-Melanocyte Stimulating Hormone (MSH) can antagonizes the anorexia induced by intracerebroventricular injection of corticotropin releasing factor (CRF). Food intake of the rats deprived of food for 18 h was significantly inhibited by 4 h after intracerebroventricular injection of CRF. alpha-MSH also suppressed food consumption by 4 h after the treatment. However, simultaneous administration of alpha-MSH attenuated the anorexic effect of CRF at 0-2 h period and food consumption for 4 h was equal to controls. In addition, simultaneous administration of alpha-MSH deleted the stimulatory effects of CRF on serum corticosterone levels. The present experiment demonstrated that alpha-MSH can antagonizes the anorexia and activation of hypothalamo-pituitary-adrenal axis by CRF, suggesting that the processing step of proopiomelanocortin may be important for the induction of anorexia elicited by CRF.
journal_name
Life Scijournal_title
Life sciencesauthors
Oohara M,Negishi M,Shimizu H,Sato N,Mori Mdoi
10.1016/0024-3205(93)90620-isubject
Has Abstractpub_date
1993-01-01 00:00:00pages
1473-7issue
19eissn
0024-3205issn
1879-0631pii
0024-3205(93)90620-Ijournal_volume
53pub_type
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