Abstract：
:The metabolism of benzene and toluene was investigated in preparations of human bone marrow incubated with S-adenosyl-L-methionine. Benzene undergoes a methyl-substitution reaction to yield toluene as a metabolite. Furthermore, toluene undergoes methyl-substitution in preparations of human bone marrow incubated with S-adenosyl-L-methionine to yield o-xylene, m-xylene, and p-xylene. Metabolites were detected by gas chromatography and mass spectroscopy. No metabolism of either benzene or toluene was detected when a boiled bone marrow preparation was used in the incubation, demonstrating the enzymatic nature of the S-adenosyl-L-methionine dependent methylation of both benzene and toluene.
journal_name
Life Scijournal_title
Life sciencesauthors
Flesher JW,Myers SRdoi
10.1016/0024-3205(91)90100-psubject
Has Abstractpub_date
1991-01-01 00:00:00pages
843-50issue
8eissn
0024-3205issn
1879-0631pii
0024-3205(91)90100-Pjournal_volume
48pub_type
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