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Platelet-activating factor stimulates production of prostaglandin E2 in murine osteoblast-like cell line MC3T3-E1.

Abstract：

:We found that platelet-activating factor (PAF) stimulated the production of prostaglandin (PG) E2 in MC3T3-E1 cells in a time- and dose-dependent manner. 1.0 microM PAF gave a maximal stimulation of PGE2 production by MC3T3-E1 cells after a 4 hr PAF-treatment. Furthermore, the PAF-induced PGE2 production was abolished by the pre-treatment of the cells with a PAF receptor antagonist, 1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine, which occupied the same receptor site as PAF. These results suggest that PAF stimulates the PGE2 synthesis through a PAF receptor mediated pathway. Possibly PAF modulates bone metabolism by stimulating PGE2 synthesis.

journal_name

Life Sci

journal_title

Life sciences

authors

Shibata Y,Ogura N,Moriya Y,Abiko Y,Izumi H,Takiguchi H

doi

10.1016/0024-3205(91)90598-6

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

1103-9

issue

15

eissn

0024-3205

issn

1879-0631

pii

0024-3205(91)90598-6

journal_volume

49

pub_type

杂志文章

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