Platelet-activating factor stimulates production of prostaglandin E2 in murine osteoblast-like cell line MC3T3-E1.

abstract：:C57BL6/J (B6) mice lacking Se-dependent GSH peroxidase 1 and 2 (GPx1/2-DKO) develop mild to moderate ileocolitis around weaning. These DKO mice have a disease resembling human very-early-onset inflammatory bowel disease (VEOIBD), which is associated with mutations in NADPH oxidase genes. Drugs including dexamethasone ...

journal_title：Life sciences

authors： Chu FF,Esworthy RS,Shen B,Gao Q,Doroshow JH

更新日期：2019-12-15 00:00:00

abstract：:Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...

journal_title：Life sciences

authors： Bastaki S,Aravindhan S,Ahmadpour Saheb N,Afsari Kashani M,Evgenievich Dorofeev A,Karoon Kiani F,Jahandideh H,Beigi Dargani F,Aksoun M,Nikkhoo A,Masjedi A,Mahmoodpoor A,Ahmadi M,Dolati S,Namvar Aghdash S,Jadidi-Niaragh F

更新日期：2021-02-01 00:00:00

abstract：:Amyloid beta-protein (A beta), the major protein of cerebrovascular and plaque amyloid in Alzheimer disease, is considered a primary factor in the pathology of this disease. The effect of synthetic A beta (1-40) on the activity of protein kinase C (PKC) was studied with histones for a substrate in a mixed micellar ass...

journal_title：Life sciences

authors： Chauhan A,Chauhan VP,Brockerhoff H,Wisniewski HM

更新日期：1991-01-01 00:00:00

abstract：:The actions of insulin-like growth factor I (IGF-I) and growth hormone (GH) on lipid metabolism have been investigated in hormonally intact rats. The subcutaneous injection of IGF-I (100 micrograms) and GH (100 micrograms) lowered total cholesterol plasma levels. The in vitro assays on isolated rat adipocytes showed a...

journal_title：Life sciences

authors： Pascual M,Larralde J,Martínez JA

更新日期：1995-01-01 00:00:00

abstract：AIMS:Paraquat (PQ) is known to induce pulmonary injury via a redox cyclic reaction. The present study was aimed to determine the protective effects of quercetin against PQ-induced pulmonary injury in association with its antioxidant activity. MAIN METHODS:Male rats were challenged acutely by PQ (50 mg/kg, i.p.) with o...

journal_title：Life sciences

authors： Park HK,Kim SJ,Kwon DY,Park JH,Kim YC

更新日期：2010-07-31 00:00:00

abstract：:Skeletal muscle viability is crucially dependent on the tissue levels of its high energy phosphates. In this study we investigated the effect of the preservation medium Perfadex and illumination with Singlet Oxygen Energy (SOE). Singlet oxygen can be produced photochemically by energy transfer from an excited photosen...

journal_title：Life sciences

authors： Lindgård A,Lundberg J,Rakotonirainy O,Elander A,Soussi B

更新日期：2003-04-25 00:00:00

abstract：AIMS:The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α-D-glucurono-α-D-manno-β-D-manno-β-D-gluco), (α-L-gulurono-β-D mannurono), β-D-gluco-β-D-mannan (PGX®)] on body weight, food consumption, glucose, insulin, and glucagon-like peptide (GLP-1) levels were determined in Zucker diabetic rat...

journal_title：Life sciences

authors： Grover GJ,Koetzner L,Wicks J,Gahler RJ,Lyon MR,Reimer RA,Wood S

更新日期：2011-02-28 00:00:00

abstract：:This experiment was designed to assess the role of the septo-hippocampal cholinergic (ACh) system in the deleterious effects produced by systemic benzodiazepine injection on learning processes in rats. Retention of a step through passive avoidance task was analysed after systemic injection of increasing doses of eithe...

journal_title：Life sciences

authors： Anglade F,Chapouthier G,Galey D

更新日期：1999-01-01 00:00:00

abstract：:The effects of (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin of tea, on Ca(2+)-permeable non-selective cation currents (NSCC) and voltage-operated Ca(2+) channels (VOCC) have been investigated in cultured rat aortic smooth muscle cells using the whole-cell voltage-clamp technique. Under the Cs(+)/t...

journal_title：Life sciences

authors： Campos-Toimil M,Orallo F

更新日期：2007-05-16 00:00:00

abstract：AIMS:Obesity is not only associated with metabolic diseases but is also a symptom of menopause in women. To date, there are no effective drugs for the management of obesity, and it is important to find new agents with fewer side effects, for the treatment of obesity. This study aimed to determine the anti-obesity effec...

journal_title：Life sciences

authors： Tsai YC,Leu SY,Chen SY,Kung CW,Lee YM,Liu YP,Yen MH,Cheng PY

更新日期：2019-09-01 00:00:00

abstract：:Alcohol-induced oxidative stress is linked to the metabolism of ethanol involving both microsomal and mitochondrial systems. Ethanol metabolism is directly involved in the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). These form an environment favourable to oxidative stress. Ethanol ...

journal_title：Life sciences

authors： Das SK,Vasudevan DM

更新日期：2007-06-27 00:00:00

abstract：:The stability of epidermal growth factor (EGF) in the gastrointestinal humen of 3-day-old suckling and 45-day-old weaned pigs was examined by incubating iodine labeled recombinant human EGF (hEGF) in the gastrointestinal fluids at 37 degrees C and monitoring the generation of acid soluble radioactivity. Chromatographi...

journal_title：Life sciences

authors： Shen WH,Xu RJ

更新日期：1996-01-01 00:00:00

abstract：:The antiestrogen tamoxifen (TAM) is widely used as a drug against breast cancer and is currently being tested as a chemopreventive agent. However, a number of studies showed genotoxic and carcinogenic effects of TAM. These effects are thought to be related to oxygen radical overproduction which occurs during TAM metab...

journal_title：Life sciences

authors： Pagano G,de Biase A,Deeva IB,Degan P,Doronin YK,Iaccarino M,Oral R,Trieff NM,Warnau M,Korkina LG

更新日期：2001-03-02 00:00:00

abstract：:Identification of the neural substrates subserving audiogenic convulsions in the GEPR is an important task and while it is not yet complete, many laboratories employing various techniques have contributed importantly to our current understanding. The present review focuses on the use of lesions to identify the neural ...

journal_title：Life sciences

authors： Browning RA

更新日期：1986-09-08 00:00:00

abstract：:Opioid peptides have been demonstrated to stimulate prolactin secretion, and it has been postulated that this is mediated, at least in part, by an effect on hypothalamic prolactin releasing and release-inhibiting factors and neurotransmitters. The aim of this study was to investigate the effect of opioid peptides and ...

journal_title：Life sciences

authors： Burns G,Baker DJ,Brown BL,Dobson PR

更新日期：1987-03-09 00:00:00

abstract：:A question whether phosphorylation is involved in adrenergic effects on cardiac tissues has long been a matter of dispute. We examined whether phosphorylation is involved in adrenergic chronotropism and inotropism in excised cardiac muscles from guinea pigs. KT5720, a specific inhibitor of A-kinase, abolished the late...

journal_title：Life sciences

authors： Gotoh H

更新日期：1995-01-01 00:00:00

abstract：:Experiments were undertaken to examine the characteristics of the adrenergic receptor-coupled cAMP system in rat brain slices. It was found that the potentiation of isoproterenol-stimulated cAMP accumulation by 6-fluoronorepinephrine, an alpha-adrenergic agonist, is largely dependent upon the degree of beta-receptor o...

journal_title：Life sciences

authors： Pilc A,Enna SJ

更新日期：1985-09-30 00:00:00

abstract：:Rats were exposed for ten months to 60 ppm of lead (Pb, as acetate) in drinking water to further assess cardiovascular effects of chronic Pb exposure. At the end of the treatment, mean blood Pb was 3.1+/-0.3 microg/dL in the control rats and 22.8+/-1.2 microg/dL in the Pb-exposed rats (means+/-SE, n=12 in each group);...

journal_title：Life sciences

authors： Carmignani M,Volpe AR,Boscolo P,Qiao N,Di Gioacchino M,Grilli A,Felaco M

更新日期：2000-12-15 00:00:00

abstract：:Insulin binding and 3-0-Methylglucose transport have been studied in erythrocyte- and reticulocyte-enriched fractions of blood cells in order to determine if the increased number of insulin binding sites in reticulocytes is associated with a glucose transport response to insulin. In these experiments rabbit reticulocy...

journal_title：Life sciences

authors： Albert SG

更新日期：1982-07-19 00:00:00

abstract：:Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can trigger fre...

journal_title：Life sciences

authors： Nobre MJ,Borelli KG,Brandão ML

更新日期：2002-11-08 00:00:00

abstract：AIMS:In the cell, both transcriptional and translational processes are tightly regulated. Cancer is a multifactorial disease characterized by aberrant protein expression. Since epigenetic control mechanisms are also frequently disrupted during carcinogenesis, they have been the center of attention in cancer research wi...

journal_title：Life sciences

authors： Biterge-Sut B

更新日期：2019-12-01 00:00:00

abstract：:The effect of fluoride ion on the binding of the specific muscarinic agonist ligand [3H]cis methyldioxolane ([3H]CD) to the mouse cardiac muscarinic receptor was investigated. Utilizing equilibrium ligand binding experiments, sodium fluoride (10mM) was shown to decrease [3H]CD binding, measured at a concentration of 2...

journal_title：Life sciences

authors： Barritt D,Yamamura HI,Roeske WR

更新日期：1982-03-08 00:00:00

abstract：:Synthetic nitric oxide donors are known to protect the gastric mucosa from damage and dietary nitrate is known to release NO in the stomach. Mast cells have been found to be involved in gastric mucosal damage in humans or in rodents, and recent studies have pointed out the possibility of nitric oxide from endogenous o...

journal_title：Life sciences

authors： Larauche M,Buéno L,Fioramonti J

更新日期：2003-08-08 00:00:00

abstract：:In a partially depolarized guinea pig papillary muscle preparation, BAY K8644 stimulated voltage-operated calcium channels, promoting slow action potentials; this effect was dose-dependent over a concentration range of 3 X 10(-7) M to 3 X 10(-6) M. Isoproterenol and histamine also induced slow action potentials by sti...

journal_title：Life sciences

authors： Mestre M,Carriot T,Néliat G,Uzan A,Renault C,Dubroeucq MC,Guérémy C,Doble A,Le Fur G

更新日期：1986-07-28 00:00:00

abstract：UNLABELLED:Based on preclinical findings, cellular therapy has become a promising therapeutic approach for neonatal hypoxia-ischemia (HI). However, before translation into the clinical setting, new and effective routes of cell delivery must be determined. Intra-arterial (IA) delivery is an attractive route of cellular ...

journal_title：Life sciences

authors： Greggio S,de Paula S,Azevedo PN,Venturin GT,Dacosta JC

更新日期：2014-02-06 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive impairments in AD, but the molecular signaling pathways underlying its neurotoxic consequences have not yet been completely explored. Additional...

journal_title：Life sciences

authors： Amidfar M,de Oliveira J,Kucharska E,Budni J,Kim YK

更新日期：2020-09-15 00:00:00

abstract：:The effects of capsaicin on cellular growth and intracellular calcium mobilization were examined in human cervical carcinoma derivation, HeLa cells. Capsaicin inhibited cellular growth and increased intracellular calcium level in HeLa cells. This capsaicin-induced intracellular calcium concentration rise was blocked b...

journal_title：Life sciences

authors： Takahata K,Chen X,Monobe K,Tada M

更新日期：1999-01-01 00:00:00

abstract：:Strips of bovine mesenteric arteries brought to sustained contraction by the addition of 3.0 microM phenylephrine relaxed when exposed to ultraviolet radiation (366 nm). The relaxation was reversible and associated with a rapid increase in the cGMP content. After termination of the radiation the cGMP level rapidly dec...

journal_title：Life sciences

authors： Karlsson JO,Axelsson KL,Andersson RG

更新日期：1984-04-16 00:00:00

abstract：:Colorectal cancer remains to be the most prevalent malignancy in humans and 1.5 million men and women living in the United States are diagnosed with colorectal cancer, with a predicted 145,600 new cases to be diagnosed in 2019. Curcuminoids and its synthetic analogs are now of interest due to their bioactive attribute...

journal_title：Life sciences

authors： Selvam C,Prabu SL,Jordan BC,Purushothaman Y,Umamaheswari A,Hosseini Zare MS,Thilagavathi R

更新日期：2019-12-15 00:00:00

abstract：:While attempting to delineate the reason for the reported extreme variability of beta-endorphin-like immunoreactivity (beta-ir) in human plasma (eg., nondetectable to 1 ng/ml) by standard radioimmunoassay, we noted that a substantial portion of circulating beta-ir was associated with erythrocytes. That erythrocyte ass...

journal_title：Life sciences

authors： Fisher A,Comly M,Do R,Tamarkin L,Ghazanfari AF,Mukherjee AB

更新日期：1984-05-07 00:00:00