Abstract:
AIMS:Resveratrol (Res) which is a polyphenolic phytoalexin, has various biological properties. In the present study, we investigated whether Res extracted from Polygonum cuspidatum can reduce oxidative damage and cognitive impairment in senescence-accelerated mouse (SAM). MAIN METHODS:Senescence-accelerated mice were administered with Res (25, 50, 100mg·kg(-1)·d(-1)) for 8weeks. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the content of malondialdehyde (MDA) in mice brain were determined. The gene expression of SOD in mice brain was investigated by real time reverse transcriptase-polymerase chain reaction (RT-PCR). KEY FINDINGS:The results showed that resveratrol significantly improved learning and memory ability in Morris water maze test and neuromuscular coordination and sensorimotor capacity in tightrope test. Meanwhile, Res increased the activities of antioxidant enzymes with a reduction in lipid peroxidation. And real time RT-PCR analysis also indicated that the change of SOD mRNA was the same as the modification of SOD activity in mice brain. Furthermore, Res could prevent cerebral mitochondrial DNA deletions which might be one of the causes resulting in learning and memory impairment. SIGNIFICANCE:These results suggest that the pharmacological action of Res may offer a novel therapeutic strategy for the treatment of age-related conditions.
journal_name
Life Scijournal_title
Life sciencesauthors
Liu GS,Zhang ZS,Yang B,He Wdoi
10.1016/j.lfs.2012.08.033subject
Has Abstractpub_date
2012-10-29 00:00:00pages
872-7issue
17-18eissn
0024-3205issn
1879-0631pii
S0024-3205(12)00483-3journal_volume
91pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Osteoarthritis (OA) is a complex joint disorder with a number of underlying physical, biochemical, biomechanical and genetic causes. Obesity is considered to be one of the major risk factors for the development and progression of OA. It actively contributes to the inflammatory status and to cartilage degradation in th...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2015.05.025
更新日期:2015-11-01 00:00:00
abstract::L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl. Haloperidol catalepsy was increased only by ivc histamine. H1 (but not H2) receptor antagonists have shown anticataleptic effect in the action of analgesics and haloperidol. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90580-5
更新日期:1983-01-01 00:00:00
abstract::Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can trigger fre...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02169-0
更新日期:2002-11-08 00:00:00
abstract::A new simplified procedure for determination of nitric oxide (NO) in biological solutions is described utilizing a new reducing system of nitric oxide prior to chemiluminescence. Advantages of the new method makes heating of the reducing solution unnecessary and avoids cooling and condensation of generated vapors. Onl...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90625-y
更新日期:1992-01-01 00:00:00
abstract::Cyclic voltammetry data were obtained for most of the main classes of antiprotozoan agents, specifically, nitroheterocycles, quinones, metal complexes and derivatives, iminium-type ions, and azo compounds. The reductions were generally reversible in the range of -0.3 to -0.9 V. Catalytic production of oxidative pressu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90740-5
更新日期:1987-10-19 00:00:00
abstract:AIMS:Toxoplasma gondii (T. gondii) is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. Its parasitic invasion leads to encephalitis, uveitis, chorioretinitis and congenital infection. Host invasion by T. gondii is mediated by Moving junction (MJ) complex formed by secretory protei...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.10.022
更新日期:2018-11-15 00:00:00
abstract::The release of liver enzymes is typically used to assess tissue damage following ischemia-reperfusion. The present study was designed to determine the impact of ischemia-reperfusion on liver function and compare these findings with enzyme release. Isolated, perfused rat livers were subjected to low flow ischemia follo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00668-2
更新日期:2000-01-01 00:00:00
abstract:AIMS:The aim of the present study was to characterize TRPV4 channels in pregnant and nonpregnant mouse uterus and examine their functional role in spontaneous and agonist-induced contractions. MAIN METHODS:We used RT-PCR, Western blot and immunohistochemistry experiments to demonstrate the presence of TRPV4 mRNA and p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.12.010
更新日期:2015-02-01 00:00:00
abstract::BIM 23014 is a somatostatin analog displaying an increased biological half life due to resistance to enzymatic degradation. This peptide inhibits GH release directly at the level of pituitary somatotrophs. In addition, an action of BIM 23014 at the level of the hypothalamus is possible since somatostatinergic fibers a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90610-2
更新日期:1992-01-01 00:00:00
abstract:AIMS:Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, has been reported to be a novel marker for the progression of chronic kidney disease (CKD). We have recently found that accumulation of ADMA could trigger peritubular capillary loss, thus contributing to tubulointerstitial ischemia ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2009.03.018
更新日期:2009-06-05 00:00:00
abstract:OBJECTIVE:To explore the effect of urantide on atherosclerotic myocardial injury by antagonizing the urotensin II/urotensin II receptor (UII/UT) system and regulating the mitogen-activated protein kinase (MAPK) signalling pathway. METHODS:Atherosclerosis (AS) was established in rats by administering a high-fat diet an...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118551
更新日期:2020-12-01 00:00:00
abstract::The binding of norepinephrine (NE) to plasma proteins of fresh human blood obtained from healthy volunteers was studied by ultrafiltration at different NE concentrations and incubation times at 37 degrees C. At 1.7 nM L-[3H]-NE binding was approximately 25%. The binding was rapid and was not influenced by the incubati...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90582-6
更新日期:1988-01-01 00:00:00
abstract::We investigated the effects of VA-045, an apovincaminic acid derivative, on isolated blood vessels. VA-045 (10(-7)-10(-5) M) and vinpocetine (10(-7)-10(-5) M) inhibited the 64 mM KCl-induced and 10(-6)M norepinephrine (NE)-induced contraction of rat aortic strips. VA-045 (10(-7)-10(-4) M) and vinpocetine (10(-7)-10(-4...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90115-j
更新日期:1993-01-01 00:00:00
abstract::The immunosuppressant cyclosporin A (CsA) has been shown to have neuroprotective action. The inhibition of both calcineurin activation and mitochondrial permeability transition pore (mtPTP) opening are considered the primary neuroprotective mechanisms of CsA. Here we have evaluated the effect of CsA on significantly r...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02267-1
更新日期:2002-12-20 00:00:00
abstract::Synthetic human pancreatic Growth Hormone-Releasing Factor (hpGRF) elevated the plasma concentration of growth hormone (GH) in young and adult domestic fowl. This in vivo effect of hpGRF appeared to be largely similar for both the 32 amino-acid (hpGRF 1-32) or 40 amino-acid (hpGRF 1-40) polypeptide, although the effec...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90083-3
更新日期:1984-03-19 00:00:00
abstract::SGK1 is one of the protein-serine/threonine kinases that is activated by insulin in a PI3K-dependent manner. Although SGK1 mediates a variety of biological activities, the mechanisms regulating its activity remain unclear. In this study, we examined the potential roles of calcium signaling in the activation of SGK1. T...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00092-4
更新日期:2003-04-04 00:00:00
abstract::To clarify the mechanism of meconium-induced cellular injury, we examined the effect of meconium on the alveolar macrophages (AM) and bronchial epithelial cells (AK-D). Meconium obtained from healthy newborns was added to culture medium of AM and/or AK-D, which were cultured for 1 hour. Superoxide anion production of ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90026-4
更新日期:1994-01-01 00:00:00
abstract::SDZ PGU 693 acts as a hypoglycemic agent by stimulating glucose utilisation in insulin-sensitive peripheral tissues, such as skeletal muscle and fat. In a 28 day toxicity study the compound was found to induce hepatocellular hypertrophy in Wistar rats treated with 300 mg/kg/day. To gain insights into the pathomechanis...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00509-8
更新日期:1998-01-01 00:00:00
abstract:AIMS:Insulinoma-associated protein 2β (IA-2β) is considered to play a significant role in regulated secretion. Recent studies have shown that the mouse brain expresses three major isoforms of IA-2β, named IA-2β60, IA-2β64, and IA-2β71. In this study, we analyzed the tissue-, cell- and organelle-specific distributions o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.02.018
更新日期:2011-04-25 00:00:00
abstract::Arsenic as a one of the most important toxic metals could induce hepatotoxicity. Previous reports revealed the significance of oxidative stress in promoting of arsenic-induced liver toxicity. The aim of the present investigation is to evaluate the effect of chrysin (CHR), a natural flavonoid with potent antioxidant ac...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118965
更新日期:2021-02-15 00:00:00
abstract::The effects of the mixed class I and II mGLUR agonist (+) 1S,3R-trans-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) and antagonists (+) alpha-methyl-4-carboxyphenylglycine (MCPG) and L-2-amino-3-phosphonopropionic acid (L-AP3) on the basal neuronal excitability and on the expression of in vitro epileptiform activity...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00941-7
更新日期:1997-01-01 00:00:00
abstract:AIMS:Solid lipid nanoparticles (SLNs) conjugated with surface 83-14 monoclonal antibody (8314MAb) and anti-epithelial growth factor receptor (AEGFR) were synthesized and applied to permeate the blood-brain barrier (BBB) and inhibit the growth of glioblastoma multiforme (GBM). MAIN METHODS:8314MAb and AEGFR were crossl...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.01.025
更新日期:2016-02-01 00:00:00
abstract::Polyinosinic polycytidylic acid (poly I:C) is an analog of double stranded RNA, which is a common replication intermediate for many viruses. It acts through a toll-like receptor (TLR3) to induce a group of cytokines that can mediate host resistance to viruses and some cancers. The effect of ethanol (EtOH) on induction...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02507-9
更新日期:2003-03-07 00:00:00
abstract::The pigeon crop-sac is a well-known target organ of prolactin (PRL). Pukac and Horseman (Endocrinology 114: 1718, 1984) reported that injections of the hormone caused changes in the expression of several specific proteins in that organ. We investigated the possibility that measuring the amounts of three of these prote...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90532-t
更新日期:1992-01-01 00:00:00
abstract:AIMS:To investigate whether the expression of nerve growth factor precursor (proNGF) changes during cardiopulmonary bypass (CPB) and whether neutralizing interleukin-6 (IL-6) during CPB has cardiac benefits. MAIN METHODS:Thirty patients undergoing CPB were recruited and their serum proNGF and troponin-I (TNI) were det...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.04.007
更新日期:2017-06-01 00:00:00
abstract::The purpose of this research is to elucidate the pharmacological mechanism mediating vesicating effects of sulfur mustard (HD) and identify an antidote to its action. HD causes blisters because epithelial cells lose their attachments. Epithelial cell adhesion is under control of the local cytotransmitter acetylcholine...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00074-2
更新日期:2003-03-28 00:00:00
abstract::We used in vitro quantitative autoradiography to investigate changes in neurotransmitter receptor binding, including muscarinic cholinergic, PCP, GABAA, benzodiazepine, D1 and 5-HT2A receptor, in the brains of aged rats, compared with such binding in young rats. Scatchard analysis revealed that the maximal number of b...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00320-3
更新日期:1994-01-01 00:00:00
abstract::Using a two-lever drug discrimination procedure, six rats were trained to discriminate 0.5 mg/kg of racemic 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) from saline. Once trained, the animals demonstrated a dose-related decrease in discriminative performance upon administration of lower doses of DOI (ED50 = 0.1...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90461-3
更新日期:1986-09-01 00:00:00
abstract::Levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat plasma were measured by radioimmunoassay and found to exhibit a circadian rhythm that parallelled the normal rhythm for corticosterone. The maximal plasma levels of both substances were observed to occur at about 1700h. The lowest concentrat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90566-6
更新日期:1984-11-12 00:00:00
abstract::Acute effect of streptozotocin-induced diabetes on several parameters of glucose metabolism was investigated in thymus lymphocytes (thymocytes). The cells from diabetics rats accumulated in vitro about 2-fold more fructose 2,6-bisphosphate (Fru-2, 6-P2) in the presence of increasing glucose concentration than cells fr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02312-7
更新日期:1996-01-01 00:00:00