Abstract:
:Sustained levels of leucine comparable to those of human Maple Syrup Urine Disease (MSUD) were achieved in blood and brain of rats by subcutaneous leucine administration twice a day from the 6th to the 28th day of life. Control rats were treated with saline in the same volumes. Behavioral studies using aversive and nonaversive tasks were performed during adult age. Chronic early leucine treatment impaired acquisition of a two-way shuttle avoidance task and altered habituation to an open field. Our results suggest that early postnatal leucine administration induces long-lasting behavioral deficits.
journal_name
Life Scijournal_title
Life sciencesauthors
Mello CF,Feksa L,Brusque AM,Wannmacher CM,Wajner Mdoi
10.1016/s0024-3205(99)00301-xsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
747-55issue
8eissn
0024-3205issn
1879-0631pii
S002432059900301Xjournal_volume
65pub_type
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