Abstract：
:The pineal gland hormone melatonin is now considered an important neuroendocrine component of animal physiology. Although the functional status of melatonin has been well described for subhuman species, there is a paucity of data concerning the physiological role of this hormone in man. This paucity of data has much to do with the limitations of experimental design imposed by the practical and ethical difficulties associated with the study of a nocturnally secreted hormone. The recent advent of salivary melatonin assay has provided a very practical means of monitoring melatonin secretion in long-term longitudinal type community based studies of pineal gland function in human health and disease. The efforts to describe key chronobiological changes in melatonin secretion of possible functional significance have been accompanied by a seemingly less enthusiastic search to describe the nature of the melatonin receptor, another highly important component of the 'melatonin message'. The functional relevance of specific chronobiological changes in melatonin secretion cannot be completely understood without an increased knowledge of melatonin action at the receptor level. The present work describes the recent methodological advance in the investigation of human pineal gland physiology represented by salivary melatonin assay, and discusses the present status of our knowledge of the melatonin receptor.
journal_name
Life Scijournal_title
Life sciencesauthors
Miles Adoi
10.1016/0024-3205(89)90262-2subject
Has Abstractpub_date
1989-01-01 00:00:00pages
375-85issue
6eissn
0024-3205issn
1879-0631pii
0024-3205(89)90262-2journal_volume
44pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract：:Since somatostatin inhibits basal and stimulated gastric acid secretion and gastrin release, it is conceivable that decreased gastric somatostatin concentration may be one of the factors responsible for gastric hypersecretion found in patients who have undergone long-term pylorotomy for hypertrophic pyloric stenosis. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00734-9
更新日期：1994-01-01 00:00:00
abstract：:Responses to [Mpr14]-ADM(14-50), a novel analog of adrenomedullin, were investigated in the hindlimb vascular bed of the cat under conditions of controlled blood flow. Intraarterial injections of [Mpr14]-rADM(14-50) in doses of 0.003-1 nmol caused dose-related decreases in hindlimb perfusion pressure. In terms of rela...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00258-5
更新日期：1996-01-01 00:00:00
abstract：:We investigated the effects of the chronic administration of hesperetin on the activation of the antioxidant defence system in mice in which oxidative stress had been induced by 7,12-dimethylbenz(a)anthracene (DMBA). Mice were divided randomly into three treatment groups. Hesperetin was administered orally to two of t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.03.002
更新日期：2008-05-23 00:00:00
abstract：:Promoter methylation is an important mechanism of regulating E-cadherin expression. Methylation-specific PCR (MSP) assay was done to evaluate the promoter methylation status of E-cadherin gene in primary tumor samples from 23 cases of Chinese women with invasive ductal breast cancers. Western blotting assay was employ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01843-x
更新日期：2002-08-09 00:00:00
abstract：:Hyperlipidemia and the glomerular accumulation of atherogenic lipoproteins (low density lipoprotein, LDL; and its oxidatively-modified variants, ox-LDL) are commonly associated with the development of glomerular mesangial proliferative diseases. However, cellular signaling mechanisms by which atherogenic lipoproteins ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.08.010
更新日期：2008-10-24 00:00:00
abstract：:Linear sucrose density gradient centrifugation of a crude synaptosomal-mitochondrial preparation of rat striatum was performed at 82,500g for 7.5, 15 and 30 min and 1, 4 and 20 h. After centrifugation various marker enzyme activities were measured throughout the gradients, viz. tyrosine hydroxylase (TH) and DOPA decar...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90248-5
更新日期：1983-08-15 00:00:00
abstract：:Ocimum sanctum, the Indian holy basil, has significant ability to scavenge highly reactive free radicals. Shade dried leaf powder of the plant was extracted with water and alcohol, and then fractionated with different solvents. Both extracts and their fractions have in vitro anti-lipidperoxidative activity at very low...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.05.036
更新日期：2004-11-19 00:00:00
abstract：:6-mercaptopurine (6-MP) has been used clinically for 40 years to maintain remission in patients with acute lymphoblastic leukemia (ALL). However, central nervous system (CNS) relapses frequently occur in patients with ALL who continuously receive anticancer drugs, including 6-MP, during remission maintenance therapy. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00637-2
更新日期：2000-01-01 00:00:00
abstract：AIMS:Anaphylactic shock sometimes accompanies pulmonary vaso- and broncho-constriction. We previously reported the hemodynamic features of mouse anaphylaxis (Life Sci. 2014; 116: 98-105). However, the effects of anaphylactic chemical mediators on the hemodynamics of in vivo mice are not well known. Furthermore, it is u...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.01.034
更新日期：2016-02-15 00:00:00
abstract：:The novel guanidines N-(3,4-dimethoxy-2-chlorobenzylideneamino)-guanidine (ME 10092) and N-(3,4-dimethoxy-2-chlorobenzylideneamino)-N1-hydroxyguanidine (PR5) were recently reported to exhibit promising cardioprotective activities in myocardial ischaemia and reperfusion in rats. The current study investigated for the f...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.03.030
更新日期：2004-09-10 00:00:00
abstract：:The effect of psychoactive agents with different clinical actions: three sedative neuroleptics (trifluoperazine, alimemazine tartrate, chlorpromazine), an anticholinergic agent (trihexyphenidyl hydrochloride), two tricyclic antidepressants (imipramine, desipramine) and lithium carbonate on the rotational correlation f...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90144-r
更新日期：1993-01-01 00:00:00
abstract：AIMS:Enhanced aerobic glycolysis is an essential hallmark of malignant cancer. Blocking the glycolytic pathway has been suggested as a therapeutic strategy to impair the proliferation of tumor cells. Metformin, a widely used anti-diabetes drug, exhibits anti-tumor properties. However, the underlying molecular mechanism...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116966
更新日期：2019-12-15 00:00:00
abstract：AIMS:To investigate the effects of curcumin on alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease (COPD) and its potential mechanism. MAIN METHODS:The rat COPD model was established by cigarette smoke exposure combined with intratracheal administration of lipopolysaccharide. Thirty-eigh...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.09.001
更新日期：2016-11-01 00:00:00
abstract：:Both in men and rats, most of the ethanol ingested at a low dose is metabolized before it reaches the systemic circulation. Oxidation of ethanol (mainly in the stomach) accounts for the bulk of this effect. This "first pass" metabolism (FPM) may be viewed as a barrier which protects against the systemic toxicity of et...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90470-9
更新日期：1985-08-12 00:00:00
abstract：AIMS:Morus, a member of the family Moraceae and commonly known as the mulberry, comprises a pharmaceutically important plant group whose major constituents are the moracins. Moracin derivatives have received great attention because they exhibit a diverse range of biological functionalities. However, no studies have con...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.060
更新日期：2018-10-01 00:00:00
abstract：:We found that platelet-activating factor (PAF) stimulated the production of prostaglandin (PG) E2 in MC3T3-E1 cells in a time- and dose-dependent manner. 1.0 microM PAF gave a maximal stimulation of PGE2 production by MC3T3-E1 cells after a 4 hr PAF-treatment. Furthermore, the PAF-induced PGE2 production was abolished...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90598-6
更新日期：1991-01-01 00:00:00
abstract：:The mouse neuroblastoma x rat glioma hybrid NG108-15 was previously shown to express delta opioid receptors. Because neuroblastoma cells display different phenotypes and cloned cell lines are heterogenous, we studied the characteristics and distribution of human 125I-beta-endorphin (125I-beta E) binding sites in cultu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90306-a
更新日期：1992-01-01 00:00:00
abstract：:Subcutaneous administration of naloxone at 1 to 10 mg/kg produced a dose-related decrease in feed intake of broiler chicks. Food deprivation for 3, 6, 12, and 24 hours produced a significant increase in feed intake compared to non-food deprived birds. Subcutaneous administration of naloxone at 1 to 10 mg/kg failed to ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90154-3
更新日期：1988-01-01 00:00:00
abstract：AIMS:The present study was designed to compare the effects of a low-fat diet (LF), calorie restriction (CR), quercetin (Que) and exercise (Ex) on hepatic steatosis in a high-fat (HF) diet-induced obesity prone (OP) model in the perspective of microRNA (miR)-dependent thyroid hormone (TH) synthesis and action. MAIN MET...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.117182
更新日期：2020-02-01 00:00:00
abstract：:Metabolic flux through the purine salvage pathway appears to modulate superoxide secretion by elicited macrophages. Exogenous adenosine, the first substrate of this pathway, stimulates superoxide secretion, and Allopurinol, a specific inhibitor of xanthine oxidase, inhibits superoxide secretion. The effects of these a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90811-1
更新日期：1983-03-21 00:00:00
abstract：AIMS:To study the underlying mechanisms of sulforaphane, a natural histone deacetylase (HDAC) inhibitor, in inhibiting triple negative breast cancer cells growth and the therapeutic effects of combination of sulforaphane and doxorubicin in TNBC treatment. MATERIALS AND METHODS:The antineoplastic activity of sulforapha...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.10.034
更新日期：2018-11-15 00:00:00
abstract：:We investigated the effect of social isolation stress on the formation of experimental liver metastasis resulted from intraportal vein (i.p.v.) injection of colon 26-L5 carcinoma cells in male Balb/c mice, and elucidated some of the underlying mechanism involving the effects of this stress on cellular immunity. Increa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00506-3
更新日期：2000-03-31 00:00:00
abstract：AIMS:Endothelin A receptor (ET(A)R) and epidermal growth factor receptor (EGFR) cross-talk enhances the metastatic potential of epithelial ovarian cancer (EOC) cells activating different pathways, including β-catenin signalling. Here, we evaluated β-catenin as one of ET(A)R/EGFR downstream pathway in the invasive behav...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.03.023
更新日期：2012-10-15 00:00:00
abstract：:Leukemias are a heterogenous group of diseases characterized by uncontrolled proliferation of abnormal blood cells of hematopoietic system. Evodiamine, a characteristic alkaloid extracted from Evodia fruits, has been reported to exhibit inhibitory effect on cell proliferation and migration in several types of cancer c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.11.025
更新日期：2004-05-21 00:00:00
abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. METHODS:A rat myocardial infarctio...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118015
更新日期：2020-09-15 00:00:00
abstract：:Tifluadom, although structurally a 1,4 benzodiazepine, has no affinity for the 3H-flunitrazepam binding site, but is a potent displacer of 3H-bremazocine from its opioid binding site. Tifluadom is characterised as an opiate kappa-receptor agonist in vitro and in vivo with potent analgesic activity in animals and no de...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90346-0
更新日期：1982-09-20 00:00:00
abstract：:The purpose of this study was to investigate the involvement of calcium in K+ currents and its effects on amino acid accumulation and on the membrane potential regulated by tri-iodo-L-thyronine (T3) in Sertoli cells. Immature rat testes were pre-incubated for 30 min in Krebs-Ringer bicarbonate buffer and incubated for...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.08.005
更新日期：2004-01-23 00:00:00
abstract：AIMS:This study was performed to assess isolated and combined effects of nandrolone and resistance training on the blood pressure, cardiac electrophysiology, and expression of the β1- and β2-adrenergic receptors in the heart of rats. MAIN METHODS:Wistar rats were randomly divided into four groups and submitted to a 6-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.04.002
更新日期：2013-05-30 00:00:00
abstract：:It has been reported that naloxone, an opioid antagonist, has antiarrhythmic activity in vivo. In Langendorff perfused rat hearts, we found that ischemia-reperfusion-induced ventricular tachyarrhythmia reverted to normal sinus rhythm after the treatment with naloxone (3 approximately 10 microM). The method of voltage ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00383-x
更新日期：1998-01-01 00:00:00
abstract：:Karyopherin α2 (KPNA2, also known as importinα-1), a member of the nuclear transporter family, is involved in the nucleocytoplasmic transport pathway of a variety of tumor-associated proteins. Recent studies have found that KPNA2 is overexpressed in various cancers, which is associated with poor prognosis. In addition...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2019.117140
更新日期：2020-01-15 00:00:00
