Abstract:
:We investigated the effects of the chronic administration of hesperetin on the activation of the antioxidant defence system in mice in which oxidative stress had been induced by 7,12-dimethylbenz(a)anthracene (DMBA). Mice were divided randomly into three treatment groups. Hesperetin was administered orally to two of the three groups at 10 and 50 mg/kg body weight for 5 weeks. Subsequently, each group was subdivided randomly into DMBA-treated and untreated groups. The DMBA-treated groups were intragastrically administered a dose of 34 mg/kg BW in corn oil vehicle twice a week for 2 weeks. The TBARS value showed a tendency to decrease following hesperetin treatment; these decreases were significantly greater in the DMBA-treated than the untreated groups. Hesperetin significantly decreased the carbonyl content at the high dose in both DMBA-treated and untreated mice. Catalase and SOD activity were increased by hesperetin; this increase was more pronounced in DMBA-treated than untreated mice. Catalase, Mn-SOD, and CuZn-SOD expression analyses supported these results. Although the GSH-px and GR activity were little affected, hesperetin treatment significantly increased the GSH/GSSG ratio in the DMBA-treated group in a dose-dependent manner. These results suggest that hesperetin shows antioxidant activity and plays a protective role against DMBA-induced oxidative stress.
journal_name
Life Scijournal_title
Life sciencesauthors
Choi EJdoi
10.1016/j.lfs.2008.03.002subject
Has Abstractpub_date
2008-05-23 00:00:00pages
1059-64issue
21-22eissn
0024-3205issn
1879-0631pii
S0024-3205(08)00115-Xjournal_volume
82pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract:HEADING AIMS:Abdominal aortic aneurysm (AAA) is featured by the growth impediment and apoptosis surge of VSMCs (vascular smooth muscle cells). MicroRNAs (miRNAs) are suggested to affect cellular behaviors including cell growth and apoptosis. This study concentrated on unraveling the emerging role of miR-28-5p in abdomi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117533
更新日期:2020-07-15 00:00:00
abstract::Chemokines constitute a large family of structurally-related small cytokines originally identified as factors regulating the migration of leukocytes in inflammatory and immune responses. Production of chemokines and their receptors in the brain has been reported under various pathological conditions. We revealed that ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2003.09.019
更新日期:2003-12-05 00:00:00
abstract::In canine renal tubular cells, the effect of Y-24180, a presumed specific platelet activating factor (PAF) receptor antagonist, on intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured by using fura-2 as a Ca(2+)-sensitive fluorescent probe. Y-24180 (0.1-10 microM) caused a rapid and sustained [Ca(2+)](i) rise...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.09.033
更新日期:2004-01-02 00:00:00
abstract::In this study, we have focused our investigation of the facts whether co-administration of a NMDA antagonist dextromethorphan (DM) with morphine during pregnancy and throughout lactation could prevent the adverse effects associated with chronic morphine administration in rat offspring. Adult female Sprague-Dawley rats...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01316-9
更新日期:2001-10-05 00:00:00
abstract:AIMS:The aim of study is to investigate the effect of nifedipine on viral myocarditis in an animal model. MAIN METHODS:Four-week-old male DBA/2 mice were inoculated with 2 pfu of encephalomyocarditis virus (EMCV) and randomized to nifedipine (n=10) or control (n=10) group. The control group was fed by regular chow and...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2009.05.018
更新日期:2009-07-31 00:00:00
abstract::The loss of gamma-aminobutyric acid (GABA)-ergic medium spiny neurons (MSNs) in the striatum is the hallmark of Huntington disease (HD), an incurable neurodegenerative disorder characterized by progressive motor, psychiatric, and cognitive symptoms. Transplantation of MSNs or their precursors represents a promising tr...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2018.07.030
更新日期:2018-09-15 00:00:00
abstract::Defects in the mitochondrial genome have been associated with Parkinson's and Alzheimer's disease, and apoptosis can be triggered by the presence of energetically compromised mitochondria. Thus, in this study we have examined whether the divalent cations Cu2+ and Mn2+ could influence mitochondrial function in vitro. M...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)00948-1
更新日期:2001-02-23 00:00:00
abstract::Oxymorphazone (at doses of 50-200 mg/kg) was found to be a relatively weak antinociceptive drug in intact frog (Rana esculenta) when acetic acid was used as pain stimulus. Frogs remained analgesic for at least 48 hrs following oxymorphazone (200 mg/kg) administration. The ligand increased the latency of wiping reflex ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90302-0
更新日期:1989-01-01 00:00:00
abstract:AIMS:The long non-coding RNA (lncRNA) was reported to be involved in the progress of various cancers, however, its effect in colorectal cancer (CRC) remains unknown. The goal of the present study is to investigate the function role of lncRNA PCAT-1 in colorectal cancer. MAIN METHODS:The expression of lncRNA PCAT-1 in ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.08.024
更新日期:2017-11-01 00:00:00
abstract::To evaluate possible deleterious effects of commonly used herbicides on leukocytes, cytokine production was selected as a sensitive indicator. After in vitro exposure of human peripheral blood mononuclear cells from normal donors, the production of all 3 cytokines tested--interferon-gamma (a type 1 cytokine), interleu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00586-5
更新日期:2000-05-19 00:00:00
abstract::We proposed that the circadian rhythm of corticosterone in diabetic rats would have a different pattern than that in non-diabetic control rats. To test this hypothesis, 20 male Sprague-Dawley rats were given ad libitum access to a stock diet and housed individually in a light and temperature controlled room. Ten rats ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90536-x
更新日期:1988-01-01 00:00:00
abstract::Although exogenous cannabinoid ligands such as delta9-tetrahydrocannabinol (THC) have been implicated in reward-related learning and aversion, the hedonic effects of the endogenous cannabinoid agonist anandamide (arachidonylethanolamide) have never been assessed. Thus, the effects of anandamide were tested in a place ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00226-4
更新日期:1998-01-01 00:00:00
abstract::Corticotropin releasing factor (CRF), one of the major effectors of stress, plays a major role in the natural course of drug addiction by accelerating the acquisition of psychostimulant self-administration and increasing incentive motivation for the drug itself and for drug-associated stimuli. Stress-induced CRF is al...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2009.11.005
更新日期:2010-01-02 00:00:00
abstract::Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2013.12.029
更新日期:2014-03-07 00:00:00
abstract::Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90198-x
更新日期:1984-02-27 00:00:00
abstract:AIMS:Acetylcholine (ACh) has been shown to increase ion and water excretion in the kidneys, resulting in hypotension. However, no evidence of renal parasympathetic innervation has been shown, and the source of ACh acting on nephrons is still unknown. The aim of the present study was to identify ACh-producing cells in t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.07.011
更新日期:2011-09-12 00:00:00
abstract::A phase 1, randomized, double-blind, placebo-controlled, dose escalation study of the purine derivative, AIT-082 (Neotrofin, NeoTherapeutics) was conducted in mild Alzheimer's disease (AD) patients to evaluate multiple-dose safety, tolerability, and pharmacokinetics. Possible short-term effects of AIT-082 on cognition...
journal_title:Life sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0024-3205(03)00320-5
更新日期:2003-06-20 00:00:00
abstract::Even though conventional systemic doses of cimetidine and other histamine H(2) antagonists display minimal brain penetration, central nervous system (CNS) effects (including seizures and analgesia) have been reported after administration of these drugs in animals and man. To test the hypothesis that cimetidine-like dr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.05.020
更新日期:2004-10-08 00:00:00
abstract:AIMS:Endothelial microparticles (EMPs) are extracellular vesicles secreted by endothelial cells. The purpose of this research is to explore that the clinical significance and roles in angiogenesis and endothelial dysfunction of circulating microparticles in Perthes disease. MAIN METHODS:We collected platelet-poor plas...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118749
更新日期:2021-01-15 00:00:00
abstract::In rats with a unilateral 6-OHDA lesion of the substantia nigra exposure to footshock or immobilization stress produced a long-lasting enhancement in the rotational behavior evoked by a subsequent injection of amphetamine. However, the effect was dependent on the environmental context in which stress was applied. It i...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90594-6
更新日期:1985-09-16 00:00:00
abstract::Male and female rats with two permanently indwelling intravenous catheters were infused for 2 hours with ovine prolactin. During equilibrium conditions the effects of intravenously injected L-DOPA and benzerazide (a blocker of dopa-decarboxylase) on steady state levels of ovine prolactin were measured. A dose of 4.5 m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90549-5
更新日期:1982-08-30 00:00:00
abstract::Involvement of a central histaminergic mechanism in the stimulating effect of beta-endorphin (beta-End) on the pituitary-adrenocortical activity, measured indirectly through corticosterone secretion, was investigated in conscious rats. The rise in serum corticosterone levels, induced by beta-End injected intraventricu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90458-n
更新日期:1991-01-01 00:00:00
abstract::Proteinase inhibitors were tested for their ability to inhibit prolactin (PRL) and growth hormone (GH) release by cultured anterior pituitary cells of the rat. Inhibitors of microbial origin (chymostatin, elastatinal, leupeptin) had either no or a moderate effect on hormone release while some tripeptide aldehydes, esp...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90636-8
更新日期:1985-02-11 00:00:00
abstract::Peripheral blood cells express the complete non-neuronal cholinergic system. For example synthesis of acetylcholine and nicotinic as well muscarinic receptors have been demonstrated in leucocytes isolated from human peripheral blood. In the present experiments mononuclear cells and granulocytes were isolated from the ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.01.010
更新日期:2007-05-30 00:00:00
abstract:AIM:The effects of local applied NO-active compounds on glutamate (GLU)-evoked responses were investigated in globus pallidus (GP) neurons. MAIN METHODS:Extracellularly recorded single units from anesthetized rats were treated with GLU before and during the microiontophoretic application of S-nitrosoglutathione (SNOG)...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.04.010
更新日期:2011-06-20 00:00:00
abstract::It was demonstrated in the previous study that the microinjection of antisense oligodeoxynucleotide (AS ODN) against mu-opioid receptor (MOR) into periaqueductal gray (PAG) of rat brain selectively decreased the MOR mRNA content in PAG, and the decrease in MOR mRNA content was enhanced by pretreatment of the PAG with ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01009-8
更新日期:2001-04-06 00:00:00
abstract:AIMS:This study aims to explore factors that influence glucocorticoid (GC)-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction (IUGR) filial rats. MAIN METHODS:An IUGR animal model was established by starvation, and brain tissue was removed after birth. Affymetrix Rat Gene 2.0 S...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.02.079
更新日期:2016-04-01 00:00:00
abstract::We have determined the effects of chronic exposure to the protein kinase C (PKC) activating drug 4-beta phorbol 12-myristate-13-acetate (PMA) on PKC isozymes and the rate of spontaneous contraction in neonatal rat cardiac myocytes in culture. Western blot analyses revealed that a two day exposure to 0.1-1 nM PMA incre...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02048-n
更新日期:1995-01-01 00:00:00
abstract:AIMS:The aims of this study were to evaluate the effects of p62/SQSTM1 expression levels on lipopolysaccharide (LPS)-induced mucus secretion in BEAS-2B bronchial epithelial cells by measuring expression levels of the MUC5AC gene and the Mucin-5AC (MUC5AC) protein. MATERIALS AND METHODS:Bronchial epithelial cells, BEAS...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.09.030
更新日期:2018-10-15 00:00:00
abstract:AIMS:Periodic acceleration (pGz) is a method that applies repetitive sinusoidal head-to-foot motion to the horizontally positioned body. pGz adds pulses to the circulation as a function of frequency, thereby increasing shear stress to the endothelium. Pulsatile shear stress increases release of cardioprotective endothe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.02.022
更新日期:2010-05-08 00:00:00