Abstract：
:Both in men and rats, most of the ethanol ingested at a low dose is metabolized before it reaches the systemic circulation. Oxidation of ethanol (mainly in the stomach) accounts for the bulk of this effect. This "first pass" metabolism (FPM) may be viewed as a barrier which protects against the systemic toxicity of ethanol. This barrier can be overcome by large doses of ethanol. Its efficiency is also reduced by a decrease in gastric alcohol dehydrogenase (ADH) activity secondary to chronic alcohol consumption.
journal_name
Life Scijournal_title
Life sciencesauthors
Julkunen RJ,Di Padova C,Lieber CSdoi
10.1016/0024-3205(85)90470-9subject
Has Abstractpub_date
1985-08-12 00:00:00pages
567-73issue
6eissn
0024-3205issn
1879-0631pii
0024-3205(85)90470-9journal_volume
37pub_type
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