Abstract：
:The effect of dihydropyridine calcium channel antagonist isradipine (PN 200-110) on morphine reinforcement has been investigated using i.v. self-administration test in rats. Rats were given the opportunity to self-administer a solution of morphine (1 mg/ml, i.v.) in a 1 hr limited access paradigm (FR = 1). Within 5-7 days rats had learned to self-administer approximately 1 mg of morphine in 1 hr as evidenced by a plateau of responding. The administration of isradipine (1.2, 2.5 and 5.0 mg/kg s.c.) 90 min before the morphine self-administration session, induced dose-dependent increase in the number of morphine self-infusions with respect to basal values. This response pattern was very similar to the one observed when morphine solution was substituted by saline in trained rats not treated with isradipine. The results indicate that isradipine inhibits partially the reinforcing properties of morphine in self-administration test.
journal_name
Life Scijournal_title
Life sciencesauthors
Kuzmin A,Martellotta MC,Fratta W,Gessa GL,Zvartau Edoi
10.1016/0024-3205(96)00397-9subject
Has Abstractpub_date
1996-01-01 00:00:00pages
PL159-64issue
11eissn
0024-3205issn
1879-0631pii
0024320596003979journal_volume
59pub_type
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