Protective effects of oleanolic acid oligoglycosides on ethanol- or indomethacin-induced gastric mucosal lesions in rats.

abstract：AIMS:Acetylcholine is synthesized in more or less all mammalian cells. However, little is known about the subcellular location of acetylcholine synthesis. Therefore, in the present experiments the subcellular location of the synthesizing enzyme choline acetyltransferase (ChAT) was investigated by anti-ChAT immunogold e...

journal_title：Life sciences

authors： Wessler I,Michel-Schmidt R,Brochhausen C,Kirkpatrick CJ

更新日期：2012-11-27 00:00:00

abstract：:Effects of amphetamine on concentrations of dopamine, norepinephrine and serotonin in several monoamine-containing cell body and terminal regions were examined left and right separately in rats. Results suggest that amphetamine reduced the L-R asymmetry of most of these measures, and this effect is more significant in...

journal_title：Life sciences

authors： Lee EH,Huang SL,Chai CY

更新日期：1987-04-06 00:00:00

abstract：:In the present study, we elucidated the possible role of hemodynamic parameters and chemical factors in the development of ventricular hypertrophy (VH) following chronic nitric oxide (NO) deprivation with Nomega-nitro-L-arginine methyl ester (L-NAME). Impedance spectral analysis was used to obtain the arterial hemodyn...

journal_title：Life sciences

authors： Hu CT,Chang HR,Hsu YH,Liu CJ,Chen HI

更新日期：2005-11-26 00:00:00

abstract：:Antroduodenal myoelectric activity was recorded in conscious sheep by electrodes chronically implanted in the muscular wall. Furthermore, plasma immunoreactive (i.r.) motilin, somatostatin and bombesin concentrations were determined by RIA. The intravenous infusion of somatostatin (20 ng/kg/min), bombesin (10 ng/kg/mi...

journal_title：Life sciences

authors： Plaza MA,Arruebo MP,Murillo MD

更新日期：1996-01-01 00:00:00

abstract：:Recently, 4.4'-bis(1-p-carboxyphenyl-3-methyl-5-dydroxyl)-pyrazol (DRD156) has been developed as a new sensitive reagent that reacts specifically with singlet oxygen. The specificity of DRD156 for singlet oxygen in a biomimetic solution (micellar solution) and the effects of its coexistence with other reagent were exa...

journal_title：Life sciences

authors： Nishide N,Miyoshi N

更新日期：2002-12-06 00:00:00

abstract：:Adenosine is a nucleoside which has been shown to participate in the regulation of physiological activity in a variety of mammalian tissues, and has been recognized as a homeostatic neuromodulator. It exerts its actions via membrane-bound receptors which have been characterized using biochemical, electrophysiological ...

journal_title：Life sciences

authors： Daval JL,Nehlig A,Nicolas F

更新日期：1991-01-01 00:00:00

abstract：:The effect of wortmannin (WT), an inhibitor of myosin light chain kinase (MLCK) as well as PI3-kinase, on catecholamine (CA) secretion in the perfused rat adrenal medulla was studied. After a 35-min application of 10 microM WT, secretory response to repetitive stimulation with 30 mM extracellular K+ was reduced to 30%...

journal_title：Life sciences

authors： Warashina A

更新日期：2000-10-13 00:00:00

abstract：:It is generally assumed that enkephalinase A, a highly thiorphan-sensitive dipeptidylcarboxypeptidase cleaving the Gly-Phe bond during enkephalin degradation, is bound to the neuronal membrane. To clarify the localization of the enzyme, we used three neuron-like models (neuroblastoma cells N1E-115, bulk prepared neuro...

journal_title：Life sciences

authors： Lentzen H,Monden I,Linke J,Palenker J

更新日期：1983-01-01 00:00:00

abstract：:Rats implanted subcutaneously with an empty osmotic pump connected by a polyethylene catheter to a jugular vein for 5 to 10 days evinced a decreased splenocyte responsiveness to blastogenic stimulation in vitro to bacterial lipopolysaccharide, a known B cell stimulator, as well as to the plant mitogens pokeweed mitoge...

journal_title：Life sciences

authors： Pross S,Newton C,Widen R,Klein TW,Friedman H,Spitzer JA

更新日期：1992-01-01 00:00:00

abstract：:This review analyses the knowledge about the incidence of transient apnoeic spells, induced by substances which activate vagal chemically sensitive afferents. It considers the specificity and expression of appropriate receptors, and relevant research on pontomedullary circuits contributing to a cessation of respiratio...

journal_title：Life sciences

authors： Szereda-Przestaszewska M,Kaczyńska K

更新日期：2019-01-15 00:00:00

abstract：:The potencies of several opioid agonists are reduced in diabetic animals and in animals made hyperglycemic via injections of glucose. In this report we examined the effects of streptozotocin-induced diabetes on the feeding responses to centrally administered opioid agonists with differing receptor selectivities. The s...

journal_title：Life sciences

authors： Gosnell BA,Grace M,Billington CJ,Levine AS

更新日期：1989-01-01 00:00:00

abstract：:A synthetic peptide corresponding to a sequence of 26 amino acids contained in endogenous rat atrial natriuretic factor (ANF), was infused into one renal artery of anesthetized dogs for a comprehensive in vivo evaluation of the renal and systemic effects of pure ANF. The results proved conclusively that ANF acted dire...

journal_title：Life sciences

authors： Seymour AA,Blaine EH,Mazack EK,Smith SG,Stabilito II,Haley AB,Napier MA,Whinnery MA,Nutt RF

更新日期：1985-01-07 00:00:00

abstract：:The metabolic capability of hepatocytes prepared by the perfusion method (P cells) and the tissue slice method (S cells) has been compared using standardised procedures. Yields of P cells were four times greater than for S cells. Trypan blue exclusion viability and oxygen utilization were similar although the viabilit...

journal_title：Life sciences

authors： Sturdee AP,Beirne JM,Sörman AE,Orton TC,Crisp DM

更新日期：1983-03-28 00:00:00

abstract：:We evaluated whether fish oil or vitamin E administration affected ethanol-induced changes in membrane ATPases. Male Wistar rats (225-250 g) were fed, through a gastric tube a liquid diet containing fish oil (25% of calories) and ethanol for one month. Another group of animals was given supplemental vitamin E (300 u/k...

journal_title：Life sciences

authors： Nanji AA,Sadrzadeh SM

更新日期：1994-01-01 00:00:00

abstract：:This study was performed in order to investigate the type of T cells recruited to the blood in response to an acute bout of exercise with regard to mean lengths of telomeric terminal restriction fragments (TRF) and surface activation markers and with special emphasis on age-associated differences. Ten elderly and ten ...

journal_title：Life sciences

authors： Bruunsgaard H,Jensen MS,Schjerling P,Halkjaer-Kristensen J,Ogawa K,Skinhøj P,Pedersen BK

更新日期：1999-01-01 00:00:00

abstract：AIMS:The study aimed to investigate whether IL-23 is amplified in monocyte subsets of MP pneumonia and to determine its relevant pathway. MATERIALS AND METHODS:We firstly analyze the IL-23p19 expression in monocyte subgroups in MP pneumonia patients and healthy controls subjects by using flow cytometry. Then, we also ...

journal_title：Life sciences

authors： Wang Z,Bao H,Liu Y,Wang Y,Qin J,Yang L

更新日期：2020-10-01 00:00:00

abstract：:Using liposomes differing in size and lipid composition, we have studied the uptake characteristics of the liver parenchymal and Kupffer cells. Desferal labeled with iron-59 was chosen as a radiomarker for the liposomal content, because Desferal in its free form does not cross cellular membranes. At various time inter...

journal_title：Life sciences

authors： Rahman YE,Cerny EA,Patel KR,Lau EH,Wright BJ

更新日期：1982-11-08 00:00:00

abstract：:Juncusol, phenolic compound, was isolated from the black needlerush, Juncus roemerianus. Different concentrations of this extract were tested for toxicity against selected species of estuarine fish and grass shrimp. Juncusol was ten times more toxic to the various species of fish than to grass shrimp. At 2.0 ppm conce...

journal_title：Life sciences

authors： de la Cruz AA,Miles DH,Chapatwala KD

更新日期：1982-05-24 00:00:00

abstract：:This study, conducted on isolated guinea pig ileum, was designed to establish the mechanism of presynaptic alpha 2-adrenoreceptor blockade by the tetramine disulfides, benextramine and pyrextramine. At 1 microM these drugs irreversibly blocked norepinephrine (NE)-induced inhibition of the twitch response to electrical...

journal_title：Life sciences

authors： Brasili L,Cassinelli A,Angeli P,Melchiorre C

更新日期：1986-05-05 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. The iNOS and COX-2 proteins and their mRNA expressions in cultured vascul...

journal_title：Life sciences

authors： Hirafuji M,Tsunoda M,Machida T,Hamaue N,Endo T,Miyamoto A,Minami M

更新日期：2002-01-11 00:00:00

abstract：:The Thirteenth International Conference on Endothelin (ET-13) was held from September 8-11, 2013 in Tokyo, Japan chaired by Noriaki Emoto, Kobe Pharmaceutical University, Japan, and Takashi Miyauchi, University of Tsukuba, Japan and held on the Tokyo Campus of Tsukuba University. The International Conferences on Endot...

journal_title：Life sciences

authors： Emoto N,Yanagisawa M

更新日期：2014-11-24 00:00:00

abstract：:L-dopa is the major treatment for Parkinson's disease (PD), but its efficacy is limited by the presence of dyskinesia. The dyskinesia develops over a period of exposure to L-dopa and is related to the dosage, therefore, the cause may involve inductive changes that produce toxic levels of metabolites, interfering with ...

journal_title：Life sciences

authors： Charlton CG,Crowell B Jr

更新日期：2000-04-21 00:00:00

abstract：:To examine the therapeutic effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on neuronal ischemia-reperfusion injury, we evaluated the neurological score in gerbils subjected to unilateral common carotid occlusion. Using the neurological score method, we selected animals which showed stroke s...

journal_title：Life sciences

authors： Hata R,Matsumoto M,Kitagawa K,Tagaya M,Matsuyama T,Sugita M,Kamada T

更新日期：1995-01-01 00:00:00

abstract：:The metabolism of haloperidol (HP) to the potentially neurotoxic pyridinium species, HPP+ and RHPP+, has been demonstrated in humans. In vitro studies in microsomes harvested from various animal species indicate that the tetrahydropyridines, HPTP and RHPTP, could be intermediates in this pathway. However, this has not...

journal_title：Life sciences

authors： Avent KM,Riker RR,Fraser GL,Van der Schyf CJ,Usuki E,Pond SM

更新日期：1997-01-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) activity increases during many growth responses. Some cells and tissues in culture also exhibit elevated enzyme activity with decreasing osmolality of the culture medium. We have found that this also occurs with uterine tissue from ovariectomized rats. Organ culture incubation under hypot...

journal_title：Life sciences

authors： Webster RA,Zaloudek CJ,Inman BC

更新日期：1984-03-26 00:00:00

abstract：:Histidine-rich glycoprotein (HRG) is a serum protein with possible pluripotent activities. In this study, a method for the quantification of rabbit histidine-rich glycoprotein (rHRG) was developed based upon the high affinity binding profile of rHRG to nickel-nitrilotriacetic acid (Ni-NTA), an improved chelation agent...

journal_title：Life sciences

authors： Mori S,Takahashi HK,Yamaoka K,Okamoto M,Nishibori M

更新日期：2003-05-23 00:00:00

abstract：:Several experiments were conducted to evaluate the effects of chronic amphetamine on the influenza A (PR-8/34) virus specific immune injury in CD-1 mice. Treatment with amphetamine resulted in a significant increase of lung virus titers and pulmonary vascular permeability. Amphetamine also increased the lethality of i...

journal_title：Life sciences

authors： Núñez MJ,Fernández-Rial JC,Couceiro J,Suárez JA,Gómez-Fernández DE,Rey-Méndez M,Freire-Garabal M

更新日期：1993-01-01 00:00:00

abstract：:Microiontophoretic study was performed to elucidate dopaminergic mechanism in the nucleus accumbens (Acc) of rats anesthetized with chloral hydrate. Iontophoretically applied dopamine produced an inhibition of glutamate-induced firing in 28 (62%) out of 45 Acc neurons tested. The dopamine-induced inhibition of 14 Acc ...

journal_title：Life sciences

authors： Akaike A,Sasa M,Takaori S

更新日期：1983-06-06 00:00:00

abstract：AIMS:Major depressive disorder, as a destructive mental health disorder, is a major contributor to disability and death. Numerous studies have illustrated that activation of inflammation and fluctuating immune reactions play a crucial role in the physiopathology of depression. The effectiveness of antidepressants is af...

journal_title：Life sciences

authors： Lan T,Bai M,Chen X,Wang Y,Li Y,Tian Y,He Y,Wu Z,Yu H,Chen Z,Chen C,Yu Y,Cheng K,Xie P

更新日期：2020-12-01 00:00:00

abstract：:The effects of subacute treatment with cocaine on activities of cocaine N-demethylase, UDP-glucuronyltransferase (GT) toward 4-nitrophenol and phenolphthalein and sulfotransferase (ST) toward androsterone and 4-nitrophenol in livers from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigat...

journal_title：Life sciences

authors： Watanabe HK,Hoskins B,Ho IK

更新日期：1988-01-01 00:00:00