Abstract:
:Several experiments were conducted to evaluate the effects of chronic amphetamine on the influenza A (PR-8/34) virus specific immune injury in CD-1 mice. Treatment with amphetamine resulted in a significant increase of lung virus titers and pulmonary vascular permeability. Amphetamine also increased the lethality of infected mice.
journal_name
Life Scijournal_title
Life sciencesauthors
Núñez MJ,Fernández-Rial JC,Couceiro J,Suárez JA,Gómez-Fernández DE,Rey-Méndez M,Freire-Garabal Mdoi
10.1016/0024-3205(93)90520-dsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
PL73-8issue
10eissn
0024-3205issn
1879-0631pii
0024-3205(93)90520-Djournal_volume
52pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract:AIMS:This study aims to evaluate the relationship between the amount of physical activity and different traditional and novel cardiometabolic risk factors, as well as atheroprotective agents, in male children and adolescents. MAIN METHODS:Cross-sectional study. A total of 337 male children and adolescents aged 7-14 ye...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.05.021
更新日期:2013-07-30 00:00:00
abstract::Bile duct ligation (BDL) in rats induces portal fibrosis. This process has been linked to changes in the oxidative state of the hepatic cells and in the production of nitric oxide. Our objective was to find possible temporal connections between hepatic redox state, NO synthesis and liver injury. In this work we have c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.01.017
更新日期:2004-06-25 00:00:00
abstract::The specific binding of 35S-t-butylbicyclophosphorothionate (TBPS) was studied in synaptosomal membranes of rat cerebral cortex. The displacing potencies of eleven CNS depressants and three convulsants were determined in the presence of 1 microM GABA and 10 nM R 5135. GABA enhanced the displacing potencies of depressa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90589-9
更新日期:1988-01-01 00:00:00
abstract::Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platf...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.01.047
更新日期:2019-04-01 00:00:00
abstract:AIMS:Colorectal cancer (CRC) is one of the most common cancers with poor prognosis worldwide. The advent of immunotherapy has greatly improved survival in refractory patients of CRC. In this study, we aimed to identify reliable immune classification and biomarkers that predict immunotherapeutic responses in CRC patient...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118368
更新日期:2020-11-15 00:00:00
abstract:AIMS:Parathyroid hormone-related protein (PTHrP) is a peptide growth factor produced in a wide range of tissues from brain and parathyroid, to kidney and uterus. The purpose of this study was to determine whether the adrenal cortical hormones, hydrocortisone (cortisol), modulate PTHrP expression and glucocorticoid rece...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.08.001
更新日期:2011-10-24 00:00:00
abstract::Because ethanol elicits a dose-dependent hydrolysis of brain sialogangliosides, we tested the possibility that injected gangliosides might antagonize intoxicating doses of ethanol. Clear anti-intoxication effects were seen at 24 hr post-injection of mixed mouse-brain gangliosides at 125-130 mg/kg, but not at lower or ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90284-6
更新日期:1988-01-01 00:00:00
abstract:AIM:Diabetic nephropathy is the leading cause of end stage renal disease in developed countries throughout the world. The imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system is the main problem that is responsible for the progression of diabetic kidney disease. In this s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.04.018
更新日期:2015-08-15 00:00:00
abstract::Cordyceps sinensis (C. sinensis) is one of the well known fungi used in traditional Chinese medicine for treatment asthma and bronchial and lung inflammation. In this study, effects of C. sinensis methanolic extracts on bronchoalveolar lavage fluids (BALF) cells proliferation, inflammatory cytokines production, and ge...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)01011-0
更新日期:2001-01-19 00:00:00
abstract::Cortical activity during motor task performance is attenuated in individuals with Parkinson disease (PD) relative to age-matched adults without PD, and this activity is enhanced with antiparkinson medication. It remains unclear, however, whether the relative change in cortical activity over the duration of the task, i...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.03.019
更新日期:2018-05-01 00:00:00
abstract::In the present study we compared, in vivo in rats, the hepatobiliary transport of monovalent (silver:Ag) and divalent metals (zinc:Zn; cadmium:Cd) with that of copper (Cu). Cu can have two oxidation states in vivo, i.e. Cu(I) and Cu(II). Studies were performed in normal Wistar (NW) rats and mutant GY Wistar rats. The ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00447-x
更新日期:1996-01-01 00:00:00
abstract::The changes in the energy charge (ATP + 0.5 ADP)/(ATP + ADP + AMP) levels of the remnant liver were studied in relation to changes in the incorporation rate of methyl-3H-thymidine into DNA, the blood ratio of acetoacetate/beta-hydroxybutyrate and indocyanine green (ICG) clearance in 70% hepatectomized rabbits. The ene...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90765-2
更新日期:1982-08-16 00:00:00
abstract::An increase in the weight of the thyroid gland, accompanied by reductions in uptake and release of 1311, serum T3 and reverse T3 concentrations and an increase in serum TSH concentration, occurs during the development of renal hypertension in rats. Renal function, as assessed by BUN, serum and urinary creatinine conce...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90274-0
更新日期:1982-02-15 00:00:00
abstract::In order to assess the relative cytokine contribution to endotoxin stimulation of pituitary-adrenocortical hormone secretion, we measured plasma levels of interleukin-1beta (IL-1beta), tumor necrosis factor (TNF alpha), adrenocorticotropin (ACTH) and corticosterone following lipopolysaccharide (LPS) challenge in rats....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00780-7
更新日期:1997-01-01 00:00:00
abstract::The pupillary effects of intravenous buprenorphine were studied in eight nondependent male subjects who reported previous opiate use. Buprenorphine (0.3, 0.6, and 1.2 mg) decreased pupil size, the amplitude of the light reflex, and the velocities of constriction and dilation. Significant pupillary effects occurred wit...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90026-8
更新日期:1991-01-01 00:00:00
abstract::Muscarinic agonists elicit contraction in the standard guinea pig ileum bioassay through activation of M3 muscarinic receptors that are also linked to phosphoinositide hydrolysis. Surprisingly, the most abundant muscarinic receptor in the ileum is the M2 which causes a specific inhibition of cyclic AMP accumulation el...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(94)00035-q
更新日期:1995-01-01 00:00:00
abstract::Different ligands of both the "peripheral" and the "central" benzodiazepine receptors were tested for their ability to induce human monocyte chemotaxis. Only the ligands interacting with the "peripheral receptor" (diazepam and Ro 5-4864) were active, and their action was blocked by the specific antagonist PK 11-195, b...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90275-8
更新日期:1993-01-01 00:00:00
abstract::The relative affinities of nortriptyline (NT) and its 10-hydroxymetabolites to rat brain muscarinic acetylcholine receptors have been determined by competition with 3H-quinuclidinyl benzilate binding. It is shown that the major NT metabolite, E-10-OH-NT, has only 1/18 the affinity of NT for the muscarinic receptor. Si...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90395-3
更新日期:1984-09-24 00:00:00
abstract::The metabolism of haloperidol (HP) to the potentially neurotoxic pyridinium species, HPP+ and RHPP+, has been demonstrated in humans. In vitro studies in microsomes harvested from various animal species indicate that the tetrahydropyridines, HPTP and RHPTP, could be intermediates in this pathway. However, this has not...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00955-7
更新日期:1997-01-01 00:00:00
abstract::The regions of muscarinic receptors that specify G-protein-coupling and ligand-binding have been defined in several recent studies. Overall, these studies have shown that amino acids within the third cytoplasmic loop of the receptors define their selectivity for different G-proteins, and that multiple, discontinuous e...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(93)90295-e
更新日期:1993-01-01 00:00:00
abstract::The antioxidative and superoxide- and hydroxyl radical-scavenging activities and pro-oxidant effect of twelve selected medicinal herbs were studied. The aqueous extracts of Coptis chinensis, Paeonia suffruticosa, Prunella vulgaris and Senecio scandens exhibited the highest potency in inhibiting rat erythrocyte hemolys...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00643-8
更新日期:2000-01-14 00:00:00
abstract:AIMS:Azelnidipine, a third-generation dihydropyridine calcium channel blocker (DHP CCB), has a characteristic hypotensive effect that persists even after it has disappeared from the plasma, which is thought to be due to its high hydrophobicity. However, because azelnidipine is unique, it might have other unknown effect...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2021.119043
更新日期:2021-01-13 00:00:00
abstract::We examined the effects of repeated administration of the selective serotonin uptake inhibitor (SSRI) fluoxetine (Flx) (5, 10, or 15 mg/kg i.p., twice daily for 21 days) on brain and plasma concentrations of the parent drug and its active desmethyl metabolite, norfluoxetine (NFlx), in rats during the 21-day regimen as...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00821-3
更新日期:1994-01-01 00:00:00
abstract::The pigeon crop-sac is a well-known target organ of prolactin (PRL). Pukac and Horseman (Endocrinology 114: 1718, 1984) reported that injections of the hormone caused changes in the expression of several specific proteins in that organ. We investigated the possibility that measuring the amounts of three of these prote...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90532-t
更新日期:1992-01-01 00:00:00
abstract::Vanilloid spice principles, including capsaicin, stimulate vasoconstriction in the rat hindlimb perfused at constant flow and, depending on dose, either stimulate or inhibit oxygen consumption by this vascular bed. We now present metabolic and functional evidence for two different vanilloid (VN1 and VN2) receptor type...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00250-a
更新日期:1995-01-01 00:00:00
abstract:AIMS:Dyslipidemia-associated diabetic retinopathy is featured by macular edema and retinal angiogenesis. This study investigated the in vitro lipotoxicity of free fatty acids and their modulatory roles in regulation of autophagy and angiogenic factor production in cultured human retinal pigment epithelium (RPE) ARPE-19...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118391
更新日期:2020-10-15 00:00:00
abstract::LH stimulation is mediated by its own receptor at the first step of the cascade, after which intracellular cAMP increases to stimulate the transcription of steroidogenic acute regulatory protein (StAR) in mouse MA-10 Leydig tumor cells. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00698-2
更新日期:2003-10-17 00:00:00
abstract::The optical isomers of apomorphine (APO) and N-propylnorapomorphine (NPA) were interacted with three biochemical indices of dopamine (DA) receptors in extrapyramidal and limbic preparations of rat brain tissue. There were consistent isomeric preferences for the R(-) configuration of both DA analogs in stimulating aden...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90596-x
更新日期:1985-09-16 00:00:00
abstract:AIMS:Obesity is not only associated with metabolic diseases but is also a symptom of menopause in women. To date, there are no effective drugs for the management of obesity, and it is important to find new agents with fewer side effects, for the treatment of obesity. This study aimed to determine the anti-obesity effec...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116672
更新日期:2019-09-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive impairments in AD, but the molecular signaling pathways underlying its neurotoxic consequences have not yet been completely explored. Additional...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.118020
更新日期:2020-09-15 00:00:00