Abstract:
:The changes in the energy charge (ATP + 0.5 ADP)/(ATP + ADP + AMP) levels of the remnant liver were studied in relation to changes in the incorporation rate of methyl-3H-thymidine into DNA, the blood ratio of acetoacetate/beta-hydroxybutyrate and indocyanine green (ICG) clearance in 70% hepatectomized rabbits. The energy charge levels of the remnant liver decreased rapidly to 0.767 from 0.856 of normal, despite a marked enhancement of mitochondrial phosphorylative activity, concomitant with the fall in blood ketone body ratio, before a maximal increase of DNA synthesis after hepatectomy. Blood ketone body ratio was correlated with hepatic energy charge (r = 0.696, p less than 0.01). After a maximal increase of DNA synthesis, hepatic energy charge levels and the blood ketone body ratios increased gradually to normal levels, concomitant with a rise in ICG clearance. Energy charge levels of the remnant liver can be evaluated by the blood ketone body ratio.
journal_name
Life Scijournal_title
Life sciencesauthors
Ozawa K,Fujimoto T,Nakatani T,Asano M,Aoyama H,Tobe Tdoi
10.1016/0024-3205(82)90765-2subject
Has Abstractpub_date
1982-08-16 00:00:00pages
647-53issue
7eissn
0024-3205issn
1879-0631pii
0024-3205(82)90765-2journal_volume
31pub_type
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