Up-regulation of HO-1 promotes resistance of B-cell acute lymphocytic leukemia cells to HDAC4/5 inhibitor LMK-235 via the Smad7 pathway.

abstract：:Following a report that nortriptyline was found useful in the control of enuresis in adults, presumably as an anticholinergic, its likely mechanism of action and apparent bladder specificity have now been investigated in vitro. The ratios of anticholinergic potencies (reciprocal of dissociation contents, Ki) for four ...

journal_title：Life sciences

authors： Rehavi M,Weiss H,Nissenkorn I,Rubinstein R,Cohen S

更新日期：1987-05-04 00:00:00

abstract：:Hepatotoxicity is a common side effect encountered with tamoxifen (TAM) administration. Due to the great value of TAM in breast cancer treatment, hepato-protection is seriously recommended. AIMS:The present study investigated the hepato-protective effect of celecoxib (CX) against TAM-induced hepatotoxicity in rats. ...

journal_title：Life sciences

authors： El-Kashef DH,El-Sheakh AR

更新日期：2019-08-15 00:00:00

abstract：:The effects of the mixed class I and II mGLUR agonist (+) 1S,3R-trans-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) and antagonists (+) alpha-methyl-4-carboxyphenylglycine (MCPG) and L-2-amino-3-phosphonopropionic acid (L-AP3) on the basal neuronal excitability and on the expression of in vitro epileptiform activity...

journal_title：Life sciences

authors： Tebano MT,Marinelli S,Sagratella S

更新日期：1997-01-01 00:00:00

abstract：:We investigated whether calcium channel antagonists would alter the induction of nitric oxide (NO) synthesis by bacterial lipopolysaccharide (LPS) alone or in combination with interferon-gamma (IFN gamma) in cultured J774 macrophages, rat vascular smooth muscle cells, rat renal mesangial cells, and rat cardiac myocyte...

journal_title：Life sciences

authors： Hattori Y,Kasai K,So S,Hattori S,Banba N,Shimoda S

更新日期：1995-01-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the effects of a mood stabilizer lamotrigine (LMG) on learning and memory processes using Morris water maze (MWM), modified elevated plus maze (mEPM) and passive avoidance (PA) tests. MAIN METHODS:Balb-c mice were used. LMG were injected (20; 40mg/kg, intraperitoneal, i.p....

journal_title：Life sciences

authors： Celikyurt IK,Ulak G,Mutlu O,Akar FY,Erden F,Komsuoglu SS

更新日期：2012-12-17 00:00:00

abstract：AIMS:The prognoses of patients with gastric cancer(GC) vary in different stages, which is mainly due to the great differences in tumor and tumor microenvironment. This study is aimed to explore the specific differences. MAIN METHODS:Based on RNAseq-based expression data from The Cancer Genome Atlas database and GSE154...

journal_title：Life sciences

authors： Wan L,Tan N,Zhang N,Xie X

更新日期：2020-11-15 00:00:00

abstract：:The growth response of aortic vascular smooth muscle cells (VSMCs) to chronic hypertension includes vascular hypertrophy. We have shown previously that angiotensin II positively regulates the expression of the human vascular smooth muscle (SM) alpha-actin gene. To further expand our understanding of vasoactive peptide...

journal_title：Life sciences

authors： Andrawis NS,Wang E,Abernethy DR

更新日期：1996-01-01 00:00:00

abstract：:There is a great deal of evidence that the ventromedial hypothalamic area (VMH) plays a significant role in glucoregulation. The present review synthesizes new and existing data in a coherent model of a hypothalamic glucoregulatory control system whose function is to stabilize blood glucose levels in the face of disco...

journal_title：Life sciences

authors： Storlien LH

更新日期：1985-02-11 00:00:00

abstract：AIMS:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel member of the betacoronaviruses family affecting the lower respiratory tract mainly through binding to angiotensin converting enzyme 2 (ACE2) via its S-protein. Genetic analysis of (ACE2) gene revealed several variants that have been suggested t...

journal_title：Life sciences

authors： Mohammad A,Marafie SK,Alshawaf E,Abu-Farha M,Abubaker J,Al-Mulla F

更新日期：2020-10-15 00:00:00

abstract：:We have evaluated the effect of intraperitoneal (I.P.) injection of human recombinant interferon-2alpha (IFN-alpha) on Bleomycin-induced pulmonary injury in hamsters. Pulmonary injury was induced by a single intratracheal (I.T.) instillation of Bleomycin (Bleo). Six groups of male Syrian hamsters were treated as follo...

journal_title：Life sciences

authors： Berkman N,Goldstein RH,Breuer R

更新日期：1997-01-01 00:00:00

abstract：:LH stimulation is mediated by its own receptor at the first step of the cascade, after which intracellular cAMP increases to stimulate the transcription of steroidogenic acute regulatory protein (StAR) in mouse MA-10 Leydig tumor cells. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of ...

journal_title：Life sciences

authors： Tsuchiya M,Inoue K,Matsuda H,Nakamura K,Mizutani T,Miyamoto K,Minegishi T

更新日期：2003-10-17 00:00:00

abstract：:Involvement of cannabinoid CB2 receptors in the IgE-mediated cutaneous reaction was investigated. Epicutaneous challenge with 2,4-dinitrofluorobenzene caused a triphasic swelling in the ear of BALB/c and C57BL/6 mice passively sensitized with anti-dinitrophenol IgE. Peak responses of the ear swelling appeared at 1 h, ...

journal_title：Life sciences

authors： Ueda Y,Miyagawa N,Wakitani K

更新日期：2007-01-09 00:00:00

abstract：AIMS:Serotonergic neurons and amino acid neurons are involved in the central nervous control of lower urinary tract function. We investigated the role of the serotonergic system in the central regulation of micturition, as well as the relationship between serotonergic neurons and amino acid neurons in the lumbosacral c...

journal_title：Life sciences

authors： Kadekawa K,Nishijima S,Sugaya K,Miyazato M,Saito S

更新日期：2009-10-07 00:00:00

abstract：:It has been suggested that dopamine might play a role in the regulation of the immune system. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the expression of mRNA for the different subtypes of dopamine receptors in the rat lymphocytes. D1, D3 and D5 receptor mRNAs were...

journal_title：Life sciences

authors： Caronti B,Calderaro C,Passarelli F,Palladini G,Pontieri FE

更新日期：1998-01-01 00:00:00

abstract：:Multidrug resistance-associated proteins (Mrps) are ATP-dependent transporters which transport a wide variety of anionic and cationic compounds. The purpose of this study was to determine the tissue distribution of Mrp5 and 6 in male and female Sprague-Dawley rats in various tissues, and to investigate whether the exp...

journal_title：Life sciences

authors： Maher JM,Cherrington NJ,Slitt AL,Klaassen CD

更新日期：2006-04-04 00:00:00

abstract：:The aim of the present study was to determine the role of adrenals in gonadal activity in the male toad during the breeding season. Exogenous administration of corticosterone or metapyrone for 6 days inhibited adrenal delta5-3beta(delta 5-3 beta) hydroxysteroid (delta5-3beta-HSD) and testicular 17beta (17 beta) hydrox...

journal_title：Life sciences

authors： Biswas NM,Chaudhuri GR,Sarkar M,Sengupta R

更新日期：2000-02-18 00:00:00

abstract：:The present study was to test whether the recently described endogenous ligand for the cannabinoid receptor; arachidonyl-ethanolamide (anandamide, ANA), may produce similar effects on pregnancy as the main psychoactive component of marihuana: delta9-tetrahydrocannabinol (THC) in rats. ANA, THC (0.02 mg/kg i.p./day, re...

journal_title：Life sciences

authors： Wenger T,Fragkakis G,Giannikou P,Probonas K,Yiannikakis N

更新日期：1997-01-01 00:00:00

abstract：:An in vitro preparation of rabbit thoracic aorta was tested in order to determine whether isometric contractile force induced by endothelin-1 (ET-1) in this preparation is changed when the tissue is exposed to ultraviolet (UV) light. After constriction of an aortic segment to a steady-state level of tension with ET-1,...

journal_title：Life sciences

authors： Nordberg LO,Raffa RB,Tallarida RJ

更新日期：1993-01-01 00:00:00

abstract：:Evidence for a drug-induced activation of central sigma systems is presented. The model is the locomotor activation initiated by a subcutaneous (SC) challenge of 1.6 mg/kg of (+)-butaclamol, (+)-BUT, given 30 min before 10 mg/kg SC of (-)-N-allylnormetazocine, (-)-NAN, in Sprague-Dawley male rats which have been pretr...

journal_title：Life sciences

authors： Iwamoto ET

更新日期：1989-01-01 00:00:00

abstract：:Since hypertension may compromise the ability to withstand hypernatremic dehydration, we investigated the impact of two experimental models of hypertension and pharmacologic normalization of blood pressure on the tolerance to chronic hypernatremic dehydration. In DOCA-salt hypertensive animals and the spontaneously-hy...

journal_title：Life sciences

authors： Trachtman H,del Pizzo R,Sturman J

更新日期：1990-01-01 00:00:00

abstract：:The temperature effects of naloxone and naltrexone (1-30 mg/kg) were examined in well habituated male rats. These drugs had a similar time course and potency, producing a dose-dependent hypothermia followed several hours later by a hyperthermia. A subsequent study found that not only did 30 mg/kg of naloxone or naltre...

journal_title：Life sciences

authors： Eikelboom R

更新日期：1987-03-16 00:00:00

abstract：:Orthodontic tooth movement induced alveolar bone resorption and formation around the teeth applied mechanical force. Although mechanical force can promote bone formation, the molecular mechanism that underlies this phenomenon is not fully understood. The purposes of this study were to determine how mechanical stress a...

journal_title：Life sciences

authors： Mitsui N,Suzuki N,Maeno M,Yanagisawa M,Koyama Y,Otsuka K,Shimizu N

更新日期：2006-05-01 00:00:00

abstract：:Skeletal muscle viability is crucially dependent on the tissue levels of its high energy phosphates. In this study we investigated the effect of the preservation medium Perfadex and illumination with Singlet Oxygen Energy (SOE). Singlet oxygen can be produced photochemically by energy transfer from an excited photosen...

journal_title：Life sciences

authors： Lindgård A,Lundberg J,Rakotonirainy O,Elander A,Soussi B

更新日期：2003-04-25 00:00:00

abstract：AIMS:Acetylcholine (ACh) has been shown to increase ion and water excretion in the kidneys, resulting in hypotension. However, no evidence of renal parasympathetic innervation has been shown, and the source of ACh acting on nephrons is still unknown. The aim of the present study was to identify ACh-producing cells in t...

journal_title：Life sciences

authors： Maeda S,Jun JG,Kuwahara-Otani S,Tanaka K,Hayakawa T,Seki M

更新日期：2011-09-12 00:00:00

abstract：:Ketamine, used clinically as an intravenous analgetic and dissociative anaesthetic agent, is a racemate with both pharmacokinetic and pharmacodynamic enantioselectivity. S-ketamine has been found have a higher clearance and greater potency than R-ketamine as well as a greater therapeutic index. We performed a study in...

journal_title：Life sciences

authors： Edwards SR,Mather LE

更新日期：2001-09-14 00:00:00

abstract：:Grape seed extract (GSE) is a commonly available dietary supplement taken for the anti-oxidant activity that's attributed to its proanthocyanidin (oligomers of monomeric polyphenols) content. Similar polyphenol-enriched preparations from blueberries and soy have shown protection against ovariectomy-induced or age-rela...

journal_title：Life sciences

authors： Kim H,Deshane J,Barnes S,Meleth S

更新日期：2006-03-27 00:00:00

abstract：:The ability of metformin (MF) to acutely relax phenylephrine (PE)-induced contraction in the isolated rat tail artery is reported to be accompanied by repolarization of the arterial smooth muscle cell (SMC) membranes. These membranes contain potassium (K) channels which if opened could mediate such repolarization and ...

journal_title：Life sciences

authors： Peuler JD,Lee JM,Smith JM

更新日期：1999-10-29 00:00:00

abstract：:Electrically evoked release of dopamine from the caudate nucleus is reduced by the dopamine receptor agonists, apomorphine and bromocriptine, and facilitated by neuroleptic drugs, which act as dopamine autoreceptor antagonists. The potencies of chlorpromazine, fluphenazine, levomepromazine and their hydroxy-metabolite...

journal_title：Life sciences

authors： Nowak JZ,Arbilla S,Dahl SG,Langer SZ

更新日期：1990-01-01 00:00:00

abstract：:Increased oxidative stress and antioxidant deficit have been suggested to play a major role in adriamycin induced cardiomyopathy and congestive heart failure due to multiple treatments with adriamycin. In this study the cardio protective effect of Centella asiatica on myocardial marker enzymes and antioxidant enzymes ...

journal_title：Life sciences

authors： Gnanapragasam A,Ebenezar KK,Sathish V,Govindaraju P,Devaki T

更新日期：2004-12-17 00:00:00

abstract：:Psoriasis is an inflammatory skin disease with preference for the skin and joints that occurs due to hyper-proliferation and abnormal apoptosis of keratinocytes. DUSP1 expression in dermal mesenchymal stem cells (MSCs) is obviously lower in psoriasis patients than that in healthy individuals. The present study aimed t...

journal_title：Life sciences

authors： Yang J,Sun L,Han J,Zheng W,Peng W

更新日期：2019-04-15 00:00:00