The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease.

abstract：:Nicotine is the main constituent of tobacco smoke responsible for the elevated risk of the cardiovascular disease and sudden coronary death associated with smoking, presumably by provoking cardiac arrhythmias. The cellular mechanisms may be related to the ability of nicotine to prolong action potentials and to depolar...

journal_title：Life sciences

authors： Wang H,Shi H,Wang Z

更新日期：1999-01-01 00:00:00

abstract：AIMS:Multiple sclerosis (MS) is one of the commonest neurologic disorders globally. LncRNA OIP5-AS1 has been found to be implicated in the etiology of MS. This study was to explore the roles and molecular mechanisms of OIP5-AS1 in the development of MS. MATERIALS AND METHODS:RT-qPCR assay was used to measure expressio...

journal_title：Life sciences

authors： Liu R,Li Y,Zhou H,Wang H,Liu D,Wang H,Wang Z

更新日期：2021-01-27 00:00:00

abstract：:The pathogenesis of abdominal aortic aneurysm remains unclear. The aim of the present study was to establish whether isoleucyl-tRNA synthetase (Iars) regulates the differentiation and apoptosis of vascular smooth muscle cells (VSMCs) during the development of abdominal aortic aneurysm (AAA). In addition, the contribut...

journal_title：Life sciences

authors： Li B,Wang Z,Chen R,Hong J,Wu Q,Hu J,Hu Z,Zhang M

更新日期：2019-05-01 00:00:00

abstract：:Low pH medium has been shown to activate the 'efferent' function of capsaicin-sensitive primary sensory neurons. Calcitonin gene-related peptide (CGRP) is released from capsaicin-sensitive afferents of guinea-pig superior sagittal and transverse sinuses (SSTS), by capsaicin or bradykinin. Here, we report that low pH m...

journal_title：Life sciences

authors： Fanciullacci M,Tramontana M,Del Bianco E,Alessandri M,Geppetti P

更新日期：1991-01-01 00:00:00

abstract：AIMS:The present study was to investigate the effect of hydrogen peroxide (H2O2) on bone marrow stem cells and their endothelial differentiation and the underlying mechanisms in vitro. MAIN METHODS:Rat bone marrow multipotent adult progenitor cells (MAPCs) were used as the source of bone marrow stem cells, and treated...

journal_title：Life sciences

authors： Xiao Y,Li X,Cui Y,Zhang J,Liu L,Xie X,Hao H,He G,Kander MC,Chen M,Liu Z,Verfaillie CM,Zhu H,Lei M,Liu Z

更新日期：2014-09-01 00:00:00

abstract：AIMS:Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. MAIN METHODS:Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assay...

journal_title：Life sciences

authors： Sogawa N,Hirai K,Sogawa C,Ohyama K,Miyazaki I,Tsukamoto G,Asanuma M,Sasaki A,Kitayama S

更新日期：2013-04-09 00:00:00

abstract：:Gastric ulceration associated with the use of NSAIDs is most frequently observed in elderly women, the same sector of society most likely to be receiving therapy for osteoporosis. As some anti-osteoporosis medications have been suggested to irritate the upper gastrointestinal mucosa, we evaluated the ability of one su...

journal_title：Life sciences

authors： Elliott SN,McKnight W,Davies NM,MacNaughton WK,Wallace JL

更新日期：1998-01-01 00:00:00

abstract：:Catecholamine uptake into PC12 cells, in the presence and absence of ATP, was measured in a bicarbonate-buffered Krebs Ringer. ATP enhanced significantly the uptake in a dose-dependent manner with maximal uptake at 1-3 mM. ATP increased the Vmax of uptake by 3-5 fold for both dopamine and norepinephrine, without a sig...

journal_title：Life sciences

authors： Eshleman A,Dunigan C,Shamoo A,Eldefrawi M

更新日期：1995-01-01 00:00:00

abstract：:Tiazofurin and retinoic acid synergistically induced differentiation and inhibited colony formation in HL-60 human promyelocytic leukemia cells in cell culture. The synergism was the result of different mechanisms of action, since the effect of tiazofurin, unlike that of retinoic acid, was prevented by addition of gua...

journal_title：Life sciences

authors： Yamaji Y,Natsumeda Y,Yamada Y,Irino S,Weber G

更新日期：1990-01-01 00:00:00

abstract：AIM:Evidence suggests that task-specific gait training improves locomotor impairments in people with incomplete spinal cord injury (SCI); however, plastic changes in brain areas remain poorly understood. The aim of this study was to examine the possible effects of a task-specific overground gait training on locomotor r...

journal_title：Life sciences

authors： Ilha J,Meireles A,de Freitas GR,do Espírito Santo CC,Machado-Pereira NAMM,Swarowsky A,Santos ARS

更新日期：2019-09-01 00:00:00

abstract：:Fluorescence spectroscopy was used to examine the biophysical characteristics of human platelet membranes as a function of subject age. The structural order of membrane lipid domains was determined with the use of 1,6-diphenyl-1,3,5-hexatriene (DPH), a fluorescent probe that preferentially localizes in the hydrocarbon...

journal_title：Life sciences

authors： Cohen BM,Zubenko GS

更新日期：1985-10-14 00:00:00

abstract：AIMS:Macrophage-derived foam-cell formation plays a crucial role in the development of atherosclerosis, and liver X receptor alpha (LXRα) is a key regulator of lipid metabolism in macrophages. Homocysteine (Hcy) is an independent risk factor of atherosclerosis; however, the regulation of lipid metabolism and role of LX...

journal_title：Life sciences

authors： Jin P,Bian Y,Wang K,Cong G,Yan R,Sha Y,Ma X,Zhou J,Yuan Z,Jia S

更新日期：2018-12-01 00:00:00

abstract：AIMS:To determine whether increased N-acetyltransferase (NAT) activity might have a toxic effect during development and an influence on folate levels since previous work has shown that only low levels of exogenous NAT can be achieved in constitutionally transgenic mice (Cao et al. 2005). MAIN METHODS:A human NAT1 tet-...

journal_title：Life sciences

authors： Cao W,Strnatka D,McQueen CA,Hunter RJ,Erickson RP

更新日期：2010-01-16 00:00:00

abstract：:Neuropathic pain syndromes respond poorly to opioid treatment. In our previous studies, we found that intrathecal (i.t.) injection of pertussis toxin (PTX) produces thermal hyperalgesia, which is poorly responsive to morphine and is accompanied by an increase in cerebrospinal fluid (CSF) levels of excitatory amino aci...

journal_title：Life sciences

authors： Wu GJ,Wen ZH,Chang YC,Yang SN,Tao PL,Wong CS

更新日期：2006-03-13 00:00:00

abstract：:Preliminary data suggest that amygdalar corticotropin-releasing factor (CRF) is regulated by nicotinic agonists. We sought to confirm and extend these observations by determining the effects of various concentrations of nicotine on CRF messenger RNA expression in the AR-5 immortalized amygdalar cell line. Nicotine pro...

journal_title：Life sciences

authors： Kasckow JW,Regmi A,Sheriff S,Mulchahey J,Geracioti TD Jr

更新日期：1999-01-01 00:00:00

abstract：:The somatostatin antagonist analogue cyclo Ahep-Phe-D-Trp-Lys-Thr(Bzl) stimulates growth in young female rats, while somatostatin itself has only equivocal effects on inhibiting growth. ...

journal_title：Life sciences

authors： Spencer GS,Hallett KG

更新日期：1985-07-08 00:00:00

abstract：:Evidence is provided for the abilities of endogenous 6-(Arg or Lys)-opioid peptides to interact with kappa-receptors as agonists. Dynorphin-(1-17) and -(1-8), alpha- and beta-neo-endorphin, [Met5]-enkephalin-Arg6-Phe7 and des acetyl salmon endorphin I significantly inhibited the electrically-evoked contractions of rab...

journal_title：Life sciences

authors： Oka T,Negishi K

更新日期：1982-10-18 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) receptor-mediated 36chloride (36Cl-) uptake was measured in synaptoneurosomes from rat brain. GABA and GABA agonists stimulated 36Cl- uptake in a concentration-dependent manner with the following order of potency: Muscimol greater than GABA greater than piperidine-4-sulfonic acid (P4S)gr...

journal_title：Life sciences

authors： Luu MD,Morrow AL,Paul SM,Schwartz RD

更新日期：1987-09-07 00:00:00

abstract：:PNA+Tempol, albumin containing conjugated (polynitroxyl albumin; PNA) and free (4-hydroxyl-2,2,6,6-tetramethyl-piperidinyl-1-oxyl; Tempol) nitroxide may protect against injury caused by reactive oxygen species. Therefore, the actions of PNA+Tempol on liver injury and inflammation induced by hepatic ischemia and reperf...

journal_title：Life sciences

authors： Blonder JM,McCalden TA,Hsia CJ,Billings RE

更新日期：2000-11-17 00:00:00

abstract：:A sensitive method for quantitation of beta-endorphin in biological fluids and tissues using ELISA methodology has been developed. This assay is sensitive to as low as 30 picograms of beta-endorphin per measurement and can be carried out in approximately 5 hours. The determination of antibody titer levels to beta-endo...

journal_title：Life sciences

authors： Sarma JM,Houghten RA

更新日期：1983-01-01 00:00:00

abstract：:Male, 5 months old, massively obese, spontaneously hypertensive rats (Obese/SHR) were given 10 mg alloxan/100 g b.w., s.c., to induce diabetes. Control Obese and non-obese/SHR were given saline. Insulin therapy was withheld. All of the animals were killed at 6 months of age. Alloxan caused a slight but statistically s...

journal_title：Life sciences

authors： Wexler BC,Mc Murtry JP

更新日期：1983-09-12 00:00:00

abstract：:Time-course studies revealed the increased susceptibility of the gastric mucosa to noxious injury in portal hypertension correlates with the level of elevated portal venous pressure and hyperglucagonemia. Whether acute elevation of portal venous pressure by exogenous glucagon aggravates such injury is not known. We te...

journal_title：Life sciences

authors： Tsui CP,Sung JJ,Leung FW

更新日期：2003-07-18 00:00:00

abstract：:The interactions of aminoglycoside, 3',4'-dideoxykanamycin B(DKB) with ATP and its related compounds were investigated. ATP, ADP, cyclic AMP and FAD bound to the DKB-conjugated Sepharose 4B column. The binding of DKB to ATP was also confirmed by equilibrium gel filtration. In the acidic pH region, the fluorescence of ...

journal_title：Life sciences

authors： Inaba A,Aramaki Y,Takahashi M,Tsuchiya S

更新日期：1986-10-13 00:00:00

abstract：AIM:The aim of the present study was to assess and compare the effect of 17β-estradiol and two different selective estrogen receptor modulators (SERMs), tamoxifen and raloxifene, as well as a selective estrogen receptor alpha agonist, propyl-pyrazole-triol (PPT) and a selective estrogen receptor beta agonist, diarylpro...

journal_title：Life sciences

authors： Baraka AM,Korish AA,Soliman GA,Kamal H

更新日期：2011-05-09 00:00:00

abstract：:Twice daily injection of caffeine (30 mg/kg) for 3-1/2 days shifted the caffeine stimulus generalization curve to the right by 3-fold in rats trained to discriminate saline from 30 mg/kg of caffeine, and by 4-fold in rats trained to discriminate saline from 10 mg/kg of caffeine. The latter group was also tested for cr...

journal_title：Life sciences

authors： Holtzman SG

更新日期：1987-01-26 00:00:00

abstract：AIMS:Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its...

journal_title：Life sciences

authors： Wang X,Pan J,Liu H,Zhang M,Liu D,Lu L,Tian J,Liu M,Jin T,An F

更新日期：2019-03-15 00:00:00

abstract：AIMS:Intra-platelet 5-HT (IP 5-HT) and YAP exhibit an important role in hepatocellular carcinoma (HCC). The aim of the study was to investigate whether IP 5-HT and YAP could affect the progression and prognosis of HCC. METHODS:5-HT level and YAP expression were measured and were compared between HCC patients and contr...

journal_title：Life sciences

authors： Liu S,Zhai M,Xiao W,Zhou Q,Zhang D,Gong Y,Deng C,Liu C,Li L,He C

更新日期：2021-01-29 00:00:00

abstract：:14C-Imipramine was administered to male and female Sprague-Dawley rats and animals were sacrificed at 4, 8, 12, and 20 hours later. At all time points, total radioactivity in female lung was several-fold higher than in males. In addition, female lungs had a higher concentration of desmethylimipramine (DMI) as compared...

journal_title：Life sciences

authors： Ginsburg E,Hirokata Y,Gram TE

更新日期：1982-03-01 00:00:00

abstract：AIMS:Endothelial microparticles (EMPs) are extracellular vesicles secreted by endothelial cells. The purpose of this research is to explore that the clinical significance and roles in angiogenesis and endothelial dysfunction of circulating microparticles in Perthes disease. MAIN METHODS:We collected platelet-poor plas...

journal_title：Life sciences

authors： Li B,Huang Q,Lin C,Lu R,Wang T,Chen X,Liu Z,Liu Y,Wu J,Wu Y,Liao S,Ding X

更新日期：2021-01-15 00:00:00

abstract：:Cocaine cues elicit craving and physiological responses. The cerebral circuits involved in these are poorly understood. The purpose of this study was to assess the relation between regional brain activation and cocaine cue elicited responses. Thirteen right-handed cocaine abusers were scanned with positron emission to...

journal_title：Life sciences

authors： Wang GJ,Volkow ND,Fowler JS,Cervany P,Hitzemann RJ,Pappas NR,Wong CT,Felder C

更新日期：1999-01-01 00:00:00