Abstract：
:Adenosine is a nucleoside which has been shown to participate in the regulation of physiological activity in a variety of mammalian tissues, and has been recognized as a homeostatic neuromodulator. It exerts its actions via membrane-bound receptors which have been characterized using biochemical, electrophysiological and radioligand binding techniques. Adenosine has been implicated in the pharmacological actions of several classes of drugs. A number of studies strongly suggest that the nucleoside may regulate cellular activity in many pathological disorders and, in that respect, adenosine derivatives appear as promising candidates for the development of new therapeutic compounds, such as anticonvulsant, anti-ischemic, analgesic and neuroprotective agents.
journal_name
Life Scijournal_title
Life sciencesauthors
Daval JL,Nehlig A,Nicolas Fdoi
10.1016/0024-3205(91)90043-bsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
1435-53issue
20eissn
0024-3205issn
1879-0631pii
0024-3205(91)90043-Bjournal_volume
49pub_type
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