Abstract：
:Plasma opioid levels were determined in 9 obese non-diabetic subjects, their 8 age matched controls, and in 29 diabetic patients; 10 maintained on diet alone, 6 on an oral hypoglycemic agent (chlorpropamide) and 13 treated with insulin. Five age matched controls for the diabetic groups were also studied for comparison. beta-endorphin and met-enkephalin levels were measured by radioimmunoassay. Enkephalin-like activity was measured by a receptor assay. Among the study groups, diabetic patients receiving insulin showed a 64% elevation of plasma beta-endorphins and diabetic patients on chlorpropamide showed a 121% increase in enkephalin-like activity. There were no statistically significant differences in the plasma met-enkephalin values in the treatment groups though levels were decreased (p less than 0.05) in diabetics vs non-diabetics. The pathophysiological importance of these alterations remains to be elucidated.
journal_name
Life Scijournal_title
Life sciencesauthors
Awoke S,Voyles NR,Bhathena SJ,Tanenberg RJ,Recant Ldoi
10.1016/0024-3205(84)90364-3subject
Has Abstractpub_date
1984-05-21 00:00:00pages
1999-2006issue
21eissn
0024-3205issn
1879-0631pii
0024-3205(84)90364-3journal_volume
34pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The present report investigated whether percentages of circulating natural killer (NK) cells and NK cell activity (NKCA) are associated with psychological variables. Subjects (n = 95) were selected, based on a combination of low or high scores on questionnaires on daily hassles and self-reported symptoms, to create fo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90002-k
更新日期：1993-01-01 00:00:00
abstract：:Semicarbazones induce an anticonvulsant effect in different experimental models. As some anticonvulsant drugs also have anti-inflammatory activity, the effects of benzaldehyde semicarbazone (BS) on models of nociception, edema and angiogenesis were investigated. BS (10, 25 or 50 mg/kg, i.p.) markedly inhibited the sec...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.01.027
更新日期：2006-06-27 00:00:00
abstract：:In the biosynthesis of adrenomedullin (AM), glycine-extended AM, an intermediate form (iAM) processed from proAM is converted to AM[1-52]-NH2, the bioactive mature form of AM (mAM), by enzymatic amidation. We earlier showed that both molecular forms of AM circulate in human plasma. In the present study, to investigate...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00208-8
更新日期：1999-01-01 00:00:00
abstract：:Bacitracin (BAC) U.S.P., obtained in the form of sterile powder, elicits dose-dependent and non-tachyphylactic contractions of the rabbit isolated aorta and of other rabbit vessels. The use of several pharmacologic antagonists suggests that BAC is a 5-hydroxytryptamine mimetic in aortic strips, since the antibiotic is...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90355-u
更新日期：1990-01-01 00:00:00
abstract：:Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2013.12.029
更新日期：2014-03-07 00:00:00
abstract：AIM:The action of oestrogen has traditionally been attributed to the activation of nuclear receptors (ERα and ERβ). A third receptor, the G protein-coupled oestrogen receptor (GPER), has been described as mediator of the rapid action of oestrogen. Based on the possible protective role of oestrogen in the cardiovascular...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.06.020
更新日期：2017-08-15 00:00:00
abstract：:Many persistent pesticides have been implicated in reproductive and developmental adverse effects, in man and wildlife. It has been hypothesized that these so-called xeno-hormones could upset the endocrine system function by binding to human estrogen receptor alpha and beta (ERalpha, beta) and thus be responsible for ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.03.023
更新日期：2006-08-15 00:00:00
abstract：:Although (-)-125I-iodopindolol (IPIN) can be used to label beta-adrenergic receptors in the central nervous system (CNS) in vivo, use of this ligand for receptor imaging studies in humans may be limited due to its relatively poor penetration into the CNS. A series of derivatives related to pindolol was therefore studi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90688-6
更新日期：1987-08-24 00:00:00
abstract：AIMS AND METHODS:We previously reported that angiotensin II (AngII) restores the vascular reactivity diminished by hemorrhagic shock. In this study, we investigated whether the beneficial effects of AngII are related to regulation of gap junctions (GJs) and connexin43 (Cx43), and the implication of MAPK signaling and m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.11.019
更新日期：2019-01-01 00:00:00
abstract：:The participation of the medullary structures in the total respiratory effect of opiates was studied by restricting the access of the delta-agonist D-ala2-D-leu5-enkephalin and the mu-agonist D-ala2-Me-Phe4-Met (O) ol5-enkephalin, to the ventral medullary surface, and by comparing their responses with those induced af...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90115-1
更新日期：1982-11-15 00:00:00
abstract：:Platelets from normal and malignant hyperthermia (MH)-susceptible pigs were evaluated for differences in 45calcium uptake in the absence or presence of caffeine (2-16 mM), halothane (0.05-0.5%), or halothane and caffeine together. There were no statistically significant differences in basal or halothane-inhibited calc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90184-d
更新日期：1991-01-01 00:00:00
abstract：:The effects of taurine on hepatic cholesterol metabolism were investigated in hamsters fed a high-fat diet or normal chow. Two weeks-treatment of taurine at 1% in drinking water prevented high-fat diet-induced increase in cholesterol levels of serum and liver. The decrease in serum cholesterol by taurine was due to de...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01507-2
更新日期：2002-04-05 00:00:00
abstract：AIM:Exosomes, the nano-units (<200 nm), released from diverse cell types in the extracellular body fluid, possess non-immunogenic property and ability to cross the blood-brain barrier (BBB). Since exosomes carry biological information from their cells of origin, we hypothesize that priming cells with potential therapeu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.04.018
更新日期：2014-06-27 00:00:00
abstract：:Visual evoked responses (VER) to counterphased gratings were recorded from area 17 of cat visual cortex prior to and following administration of diisopropylfluorophosphate (DFP). The VER and acetylcholinesterase (AChE) activity of blood, retina, and visual cortex were reduced significantly following DFP administration...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90282-7
更新日期：1987-12-14 00:00:00
abstract：:Bovine brain phospholipid liposomes (BC-PL) reduce plasma prolactin (PRL) levels in humans after acute administration and counteract the metoclopramide- and sulpiride-induced hyperprolactinaemia. However, BC-PL, like nomifensine, a dopamine (DA) reuptake inhibitor and therefore an indirect dopaminergic compound, does ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90395-2
更新日期：1982-07-05 00:00:00
abstract：:The present study was undertaken to evaluate the cardioprotective potential of Curcuma longa (Turmeric) in the ischemia-reperfusion (I/R) model of myocardial infarction (MI). Wistar rats were divided into three groups and received saline orally (sham, control I/R group) and Curcuma longa 100 mg/kg (CL-100 treated grou...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.02.032
更新日期：2004-08-20 00:00:00
abstract：:Sodium spirulan (Na-SP) is a sulfated polysaccharide with M(r) approximately 220,000 isolated from the blue-green alga Spirulina platensis. The polysaccharide consists of two types of disaccharide repeating units, O-hexuronosyl-rhamnose (aldobiuronic acid) and O-rhamnosyl-3-O-methylrhamnose (acofriose) with sulfate gr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.09.061
更新日期：2004-03-26 00:00:00
abstract：:In view of the toxicity of cocaine and recent reports on the antimuscarinic properties of cocaine, the present study evaluated the effects of manipulations in cholinergic neurotransmission on the lethal effects of cocaine. Physostigmine pretreatment significantly altered the lethality of cocaine, increasing the LD 50 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90111-2
更新日期：1989-01-01 00:00:00
abstract：:The present investigation examined the correlation between the regulation of mucosal prostaglandin (PG) biosynthesis and the release of the neuropeptide substance P (SP) in rat stomachs by indomethacin, a cyclooxygenase inhibitor. When given subcutaneously at the dose of 5 mg/kg, indomethacin reduced mucosal biosynthe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00117-3
更新日期：1997-01-01 00:00:00
abstract：:Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors, CysLT1 and CysLT2, have been cloned and functionally characterised using potent CysLT1 receptor antagonists and the dual CysLT1/CysLT2 receptor...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(02)01733-2
更新日期：2002-06-28 00:00:00
abstract：:Arginine vasotocin has been proposed as a hormone of the mammalian pineal gland. This claim is largely based on biological and immunological results, although some chemical evidence has also been provided. Yet, more and more researchers have recently disclaimed the presence of this nonapeptide in mammalian tissue. The...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(84)90267-4
更新日期：1984-10-22 00:00:00
abstract：:Three distinct peptidyldipeptidases (exopeptidases releasing carboxyl terminal dipeptide residues) can be solubilized from nerve terminal membrane fractions from whole rat brain or striatum, and separated by ion exchange chromatography. Brain angiotensin-converting enzyme (PDP-1) cleaves Hip-His-Leu, but not 80 nM [3H...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90435-6
更新日期：1983-01-01 00:00:00
abstract：AIMS:Normal human cells in culture progressively lose their capacity for replication, ending in an irreversible arrested state known as replicative senescence. Senescence has been functionally associated to the process of organismal ageing and is also considered a major tumor-suppressing mechanism. Although a great dea...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.11.009
更新日期：2009-01-16 00:00:00
abstract：:Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how auto...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118184
更新日期：2020-10-15 00:00:00
abstract：:The presence of gonadotropin-releasing hormone (GnRH) binding sites in biopsy samples of human epithelial ovarian cancer and ovarian tumor cell lines as well as the demonstration of the inhibitory effects of GnRH analogues on the growth of these cells raised the possibility that GnRH is produced locally by ovarian can...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00173-8
更新日期：1998-01-01 00:00:00
abstract：:Adult rat offspring earlier exposed to maternally ingested caffeine during both gestation and lactation were observed in an open field following acute administration of diazepam or cyclohexyladenosine. While both drugs reduced measures of locomotion and emotional reactivity, caffeine-exposed rats showed evidence of gr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)80009-9
更新日期：1996-01-01 00:00:00
abstract：:The aim of this study was to assess the anxiolytic effect of berberine (abbrev. BER) using two experimental anxiety models in the mouse. In the black and white test of anxiety, berberine (100, 500 mg/kg) produced an increase in the first time entry, time spent in the white section, and total changes between two compar...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.04.032
更新日期：2004-10-01 00:00:00
abstract：:The recently discovered highly specific delta opioid antagonist H-Tyr-Tic-Phe-Phe-OH (TIPP) was radiolabelled by catalytic tritiation of its precursor [Tyr (3', 5'-I2)1]TIPP. The tritiated ligand labelled rat brain membrane binding sites with a Kd value of 0.64 nM and a Bmax of 82 fmol/mg protein. Binding competition ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90649-n
更新日期：1993-01-01 00:00:00
abstract：:Adrenals of young adult male mice kept on a LD 12:12 lighting regimen for three weeks prior to study and harvested at four different circadian stages were incubated for 2 hours with 0.4 IU synthetic ACTH in 2 ml Krebs-Ringer buffer (KR), or with 50, 150, and 450 microM of melatonin in KR containing 0.4 IU ACTH. The ad...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00079-3
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. METHODS:A rat myocardial infarctio...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118015
更新日期：2020-09-15 00:00:00
