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Antinociceptive, antiedematogenic and antiangiogenic effects of benzaldehyde semicarbazone.

Abstract：

:Semicarbazones induce an anticonvulsant effect in different experimental models. As some anticonvulsant drugs also have anti-inflammatory activity, the effects of benzaldehyde semicarbazone (BS) on models of nociception, edema and angiogenesis were investigated. BS (10, 25 or 50 mg/kg, i.p.) markedly inhibited the second phase of nociceptive response induced by formaldehyde (0.34%, 20 microl) in mice, but only the highest dose inhibited the first phase of this response. The thermal hyperalgesia and mechanical allodynia induced by carrageenan (1%, 50 microl, i.pl.) in rats were also inhibited by BS (50 mg/kg, i.p.). However, treatment of mice with BS did not induce an antinociceptive effect in the hot-plate model. The paw edema induced by carrageenan (1%, 50 microl, i.pl.) in rats was inhibited by BS (25 or 50 mg/kg, i.p.). Treatment of mice with BS (0.25, 0.5 or 2.5 mg/kg/day, i.p., 7 days) also inhibited angiogenesis induced by subcutaneous implantation of a sponge disc. It is unlikely that the antinociceptive effect induced by BS results from motor incoordination or a muscle relaxing effect, as the mice treated with this drug displayed no behavioral impairment in the rotarod apparatus. In conclusion, we demonstrated that BS presents antinociceptive, antiedematogenic and antiangiogenic activities. An extensive investigation of the pharmacological actions of BS and its derivatives is justified and may lead to the development of new clinically useful drugs.

journal_name

Life Sci

journal_title

Life sciences

authors

Rocha LT,Costa KA,Oliveira AC,Nascimento EB Jr,Bertollo CM,Araújo F,Teixeira LR,Andrade SP,Beraldo H,Coelho MM

doi

10.1016/j.lfs.2006.01.027

subject

Has Abstract

pub_date

2006-06-27 00:00:00

pages

499-505

issue

5

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(06)00094-4

journal_volume

79

pub_type

杂志文章

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