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Acetylcholine synthesis and muscarinic receptor subtype mRNA expression in T-lymphocytes.

Abstract：

:We used a sensitive and specific radioimmunoassay for acetylcholine (ACh), and detected significant amounts of ACh in the blood of various mammals, including humans. About 60% of human blood ACh was localized in mononuclear leukocytes. Human leukemic T-cell lines, used as T-lymphocyte models, contained both ACh and choline acetyltransferase (ChAT) activity. Furthermore, ChAT mRNA and protein were detected in the T-cell line MOLT-3. Phytohemagglutinin, a T-cell activator, increased both synthesis and release of ACh by MOLT-3 cells. Muscarinic receptor subtype mRNA expression was confirmed in various T-cell lines. These findings indicate that ACh synthesized by ChAT in T-lymphocytes acts on the muscarinic receptors on lymphocytes in autocrine and/or paracrine pathways and suggest that ACh in blood functions as a modulator of T-cell-dependent immune responses.

journal_name

Life Sci

journal_title

Life sciences

authors

Kawashima K,Fujii T,Watanabe Y,Misawa H

doi

10.1016/s0024-3205(98)00131-3

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

1701-5

issue

17-18

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(98)00131-3

journal_volume

62

pub_type

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