Abstract：
:Effects of 1-methyl-4-phenylpyridine(MPP+), a putative neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP), on the contents of dopamine were examined in the various regions of the rat brain. Under anesthesia with pentobarbital sodium and flunitrazepam, MPP+ 150 micrograms/rat was intracerebroventricularly infused for 5 hours, at 30 micrograms/100 microliters/hr. Seven days later, the contents of dopamine, but not those of noradrenaline and activities of choline acetyl transferase in the brain were found to be significantly decreased, as compared to findings in the respective controls. The MPP+-induced depletion of dopamine was most evident in the striatum (38% of control). Contents of dopamine in the substantia nigra and ventral tegmental area were not significantly affected by MPP+. These results are interpreted to mean that intracerebroventricular continuous infusion of MPP+, in a relatively low concentration, induces a moderate but relatively specific disruption of central dopaminergic nerve terminals in rats, presumably by the selective accumulation of this neurotoxic agent into these nerve terminals.
journal_name
Life Scijournal_title
Life sciencesauthors
Okada M,Yokotani K,Yamashita M,Ikeda H,Osumi Ydoi
10.1016/0024-3205(89)90625-5subject
Has Abstractpub_date
1989-01-01 00:00:00pages
391-9issue
5eissn
0024-3205issn
1879-0631pii
0024-3205(89)90625-5journal_volume
45pub_type
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