Abstract：
:Polyamines have been shown to relax several types of smooth muscle including vasculature. In the estrogen-treated uterus, uterine blood flow and polyamine levels in the uterus are increased. The relaxant effect of polyamines on blood vessels suggest that polyamines may act on uterine vasculature to cause uterine hyperemia. In this study, we examined the roles of polyamines in regulating uterine blood flow. Ovariectomized rats were administered with polyamines or estrogen. The uterine blood flow was then measured by employing radioactive microspheres. The direct injection of polyamines into systemic circulation caused a 3-fold increase in uterine blood flow within 30 seconds. The polyamine-induced uterine hyperemia was counteracted by increasing extracellular calcium concentration. When rats were treated with estradiol, uterine blood flow increased. However, the treatment with alpha-difluromethylornithine, a polyamine synthesis inhibitor, did not attenuate the estrogen-induced uterine blood flow. Our results suggest that polyamines may affect uterine blood flow via antagonizing the entry of extracellular calcium. However, the detailed mechanisms via which polyamines involved in estrogenic stimulation of uterine hyperemia may require further studies.
journal_name
Life Scijournal_title
Life sciencesauthors
Wing LYdoi
10.1016/0024-3205(92)90446-vsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
1607-14issue
21eissn
0024-3205issn
1879-0631pii
0024-3205(92)90446-Vjournal_volume
50pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：AIMS:Normal human cells in culture progressively lose their capacity for replication, ending in an irreversible arrested state known as replicative senescence. Senescence has been functionally associated to the process of organismal ageing and is also considered a major tumor-suppressing mechanism. Although a great dea...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.11.009
更新日期：2009-01-16 00:00:00
abstract：:It is generally assumed that enkephalinase A, a highly thiorphan-sensitive dipeptidylcarboxypeptidase cleaving the Gly-Phe bond during enkephalin degradation, is bound to the neuronal membrane. To clarify the localization of the enzyme, we used three neuron-like models (neuroblastoma cells N1E-115, bulk prepared neuro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90455-1
更新日期：1983-01-01 00:00:00
abstract：:Effect of mitragynine, an indole alkaloid isolated from Thai medicinal plant kratom (Mitragyna speciosa), on electrically stimulated contraction was studied in the guinea-pig ileum. Mitragynine (1 nM-3 microM) inhibited the ileum contraction elicited by electrical stimulation, and its pD2 value was 6.91 +/- 0.04 (n = ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00023-4
更新日期：1997-01-01 00:00:00
abstract：:Experiments were done to examine the analgesic effect of thiorphan alone or in combination with stress in mice. Analgesia was assessed by measuring jump latencies from a 55 degrees C hot plate. Thiorphan exhibited weak analgesic properties evidenced by significant increases in jump latencies only after 300 mg/kg i.p. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90338-1
更新日期：1982-09-20 00:00:00
abstract：:This work was designed to study neurogenic, atropine resistant contractions of the cat urinary bladder. Urinary bladder contractions were induced by pelvic nerve stimulation (PNS) and the administration of acetylcholine (Ach) and purine compounds. The results show that atropine (2 mg/kg) depresses the maintained porti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90374-0
更新日期：1983-05-23 00:00:00
abstract：:The effects of 100 microM norepinephrine (NE), GABA, aspartate, glutamate, and carbachol on the release of endogenous NE, GABA, aspartate, and glutamate from slices of rat cerebellum were examined. The 35 mM K+-stimulated release of NE was potentiated by GABA (136% of control), glutamate (123%), and carbachol (123%); ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90308-5
更新日期：1986-01-20 00:00:00
abstract：AIMS:Recent evidence has shown that systemic administration of sulfonylureas and biguanides block the diclofenac-induced antinociception, but not the effect produced by indomethacin. However, there are no reports about the peripheral interaction between analgesics and the biguanides metformin and phenformin. Therefore,...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.10.009
更新日期：2012-01-02 00:00:00
abstract：:The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg,...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.06.017
更新日期：2003-11-07 00:00:00
abstract：:The binding of membrane immunoglobulin (mIg) by anti-Ig antibodies is known to initiate a mitogenic signal in B lymphocytes. Because in many instances growth control appears to be correlated with phosphokinase activity, as well as with alterations in cytoskeletal architecture, we asked the question whether antibodies ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90089-6
更新日期：1988-01-01 00:00:00
abstract：:Maternal malnutrition is known to impair fetal growth and predispose to the development of hypertension and type 2 diabetes. Recently, studies have demonstrated that intrauterine malnutrition is followed later in male offspring by oxidative stress characterized by increased superoxide generation due to activation of N...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.10.028
更新日期：2007-01-30 00:00:00
abstract：AIMS:To potentiate the well-documented tumor protecting ability of paullones, literatures demand for rational modifications in paullone ring structure and exploration of a precise mechanism underlying their antitumor effects. Thus, recently we synthesized novel paullone-like scaffold, 5H-benzo [2, 3][1,4]oxazepino[5,6-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.02.029
更新日期：2018-05-15 00:00:00
abstract：:Platelets from normal and malignant hyperthermia (MH)-susceptible pigs were evaluated for differences in 45calcium uptake in the absence or presence of caffeine (2-16 mM), halothane (0.05-0.5%), or halothane and caffeine together. There were no statistically significant differences in basal or halothane-inhibited calc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90184-d
更新日期：1991-01-01 00:00:00
abstract：AIMS:Diabetic nephropathy is a growing health concern, which is reported to be associated with inflammation. Luteolin has been explored for the treatment of some diabetic complications. Although several studies have verified the effect of luteolin on diabetic nephropathy, the mechanism by which the therapeutic effects ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.03.073
更新日期：2019-05-15 00:00:00
abstract：AIMS:Oxidative stress emerges after reperfusion of an organ following an ischemic period and results in tissue damage. In the heart, an amplified generation of reactive oxygen species and a significant Ca(2+) accumulation cause ventricular arrhythmias and mitochondrial dysfunction. This occurs in consequence of increas...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.12.026
更新日期：2014-02-06 00:00:00
abstract：:Central dopaminergic (DA) function in children was assessed by monitoring plasma-free homovanillic acid (pHVA) levels after brief (18 hour) administration with debrisoquin sulfate, a peripherally active antihypertensive agent that blocks peripheral, but not central, HVA production. Brief debrisoquin administration res...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90239-0
更新日期：1986-03-17 00:00:00
abstract：:The effects of caffeine (Cf), theophylline (Tph) and theobromine (Tb) on the adrenal cortex were studied. No direct effect (hypophysectomized: hypo(-) rats) was observed with any of the three methyl-xanthines (MX) after chronic oral administration (5 days). An indirect effect (via the hypothalamo-hypophyseal-adrenal a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90131-6
更新日期：1985-09-30 00:00:00
abstract：:Nitric oxide (NO) is a key mediator in many physiological processes and one of the major receptors through which NO exerts its effects is soluble guanylyl cyclase. Guanylyl cyclase converts GTP to cyclic GMP as part of the cascade that results in physiological processes such as smooth muscle relaxation, neurotransmiss...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02361-5
更新日期：2003-01-17 00:00:00
abstract：:Hyperglycemia and/or hypoinsulinemia have been found to inhibit L-ascorbic acid cellular transport. The resultant decrease in intracellular ascorbic acid may de-inhibit aryl sulfatase B and increase degradation of sulfated glycosaminoglycans (sGAG). This could lead to a degeneration of the extracellular matrix and res...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90130-j
更新日期：1990-01-01 00:00:00
abstract：:A number of experimental studies report that biological systems can be affected by in vivo exposure to low frequency and extremely low frequency electromagnetic fields. However, attempts to independently replicate some of these studies have shown the reported effects to be elusive. The difficulty in replicating result...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00770-4
更新日期：1997-01-01 00:00:00
abstract：:Stimulation of the preganglionic trunk of the ipsilateral superior cervical sympathetic ganglion with square wave electrical pulses produced secretion from the main excretory duct of the rabbit lacrimal gland. The secretion was inhibited by propranolol (1 mg/kg) and metoprolol (10 mg/kg) but not by phenoxybenzamine (2...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90424-7
更新日期：1984-06-11 00:00:00
abstract：AIMS:To investigate the effects of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) on cognitive dysfunction, the expression of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and amyloid β peptide (Aβ) in the hippocampus, as well as dendritic pathology in the hippocampal CA1 region in sepsis-associate...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116822
更新日期：2019-10-15 00:00:00
abstract：:Based on the finding of decreased mitochondrial complex I activity in the substantia nigra of patients with Parkinson's disease, we propose that the consequent reduction of ATP synthesis and increased generation of reactive oxygen species may be a possible cause of nigrostriatal cell death. Since sulfhydryl groups are...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(98)00472-x
更新日期：1999-01-01 00:00:00
abstract：:The present study was designed to investigate the effects of chronic administration of the alcoholic extract of Terminalia arjuna (TAAE) bark on isoproterenol induced myocardial injury. The TAAE was administered orally to Wistar albino rats (150-200 g) in three different doses, by gastric gavage [3.4 mg/kg: (T1), 6.75...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00671-4
更新日期：2003-10-10 00:00:00
abstract：UNLABELLED:Based on preclinical findings, cellular therapy has become a promising therapeutic approach for neonatal hypoxia-ischemia (HI). However, before translation into the clinical setting, new and effective routes of cell delivery must be determined. Intra-arterial (IA) delivery is an attractive route of cellular ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.10.017
更新日期：2014-02-06 00:00:00
abstract：:Reoxygenation of the ischemic tissue promotes the generation of various reactive oxygen metabolites (ROM) which are known to have deleterious effects on various cellular functions. This study was designed to determine the possible protective effect of mesna (2-Mercaptoethane Sulfonate) on renal ischemia/reperfusion (I...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.04.029
更新日期：2004-09-24 00:00:00
abstract：:Sleep is crucial to improve athlete performance and their circadian rhythm, but sleep patterns may be disturbed because athletes participate in several competitions. In addition, intensive training programs can cause muscle pain and psychological stress in athletes, resulting in a lack of sleep. Sleep also plays a cri...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116835
更新日期：2019-10-15 00:00:00
abstract：:In a guinea-pig model of asthma, active immunization against substance P (SP) prevented the development of airways' hyperresponsiveness and reduced bronchospastic responses to SP (i.v.). The rat-mouse heterohybridoma NC1/34 secretes a specific, rat IgG1, anti-substance P antibody (alpha-SP Ab) which was isolated and p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00255-5
更新日期：1995-01-01 00:00:00
abstract：:Cloned human MCF-7 breast tumor cells were prevented from proliferating when grown in charcoal-dextran stripped human female serum (CDFHS)-supplemented media (40% and 10%); this inhibition was maximally cancelled by estradiol-17, cisTamoxifen, and Metabolite E, whereas Tamoxifen, N-desmethylTamoxifen and Metabolite Y ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90510-7
更新日期：1985-07-29 00:00:00
abstract：AIMS:The purposes of this study were to determine whether Cervi Pantotrichum Cornu (CPC) has osteogenic activities in human osteoblastic MG-63 cells and to investigate the underlying molecular mechanism. MAIN METHODS:The effects of CPC on alkaline phosphatase activity, collagen synthesis, and calcium deposits were mea...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.11.002
更新日期：2014-01-14 00:00:00
abstract：:Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2013.12.029
更新日期：2014-03-07 00:00:00
