Abstract：
:Calcitonin secretion is influenced by estrogen. In the present study, basal and calcium-stimulated serum calcitonin levels were reduced in ovariectomized rats, and replacement estrogen administered for 3 weeks increased both calcitonin levels to those in intact rats. Ipriflavone, 7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one, alone did not influence either calcitonin level. However, ipriflavone and subeffective doses of estrogen administered simultaneously increased both levels; the increase depended upon the dose of ipriflavone. Furthermore, pretreatment with estrone resulted in greater calcitonin release in response to various doses of calcium and pretreatment with estrone and ipriflavone caused an even greater release. These findings indicate that ipriflavone increases the sensitivity of the thyroid gland to estrogen to secrete calcitonin in response to calcium.
journal_name
Life Scijournal_title
Life sciencesauthors
Yamazaki I,Kinoshita Mdoi
10.1016/0024-3205(86)90492-3subject
Has Abstractpub_date
1986-04-28 00:00:00pages
1535-41issue
17eissn
0024-3205issn
1879-0631pii
0024-3205(86)90492-3journal_volume
38pub_type
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