Renal effects of administered atrial natriuretic peptide in the conscious, aging rat.

Abstract:

:Studies were performed in conscious, chronically catheterized male Sprague-Dawley rats to investigate the effect of administered atrial natriuretic peptide (ANP) on blood pressure, renal hemodynamics and urinary electrolyte excretion. Studies were performed on young adult (3-4 month old) rats and on aging rats (18-24 months of age). Low dose ANP (80 ng/kg/min for 60 min) had no effects on renal hemodynamics in either young or old rats and produced only a slight blood pressure reduction in young animals. No effect on urinary electrolyte excretion was evident in young rats whereas in the old animals, low dose ANP produced large rises in the rate of sodium excretion, fractional excretion of sodium and urine flow rate. A four fold higher dose of ANP evoked a moderate natriuretic and a marked antihypertensive response in young rats. Time control studies indicated that time alone had no influence on urinary sodium excretion rate, the fractional excretion of sodium or urine flow rate. These studies indicate a much enhanced sensitivity to the natriuretic effects of administered ANP by the kidneys of old rats.

journal_name

Life Sci

journal_title

Life sciences

authors

DePriest D,Zimmermann C,Baylis C

doi

10.1016/0024-3205(90)90066-z

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

785-92

issue

11

eissn

0024-3205

issn

1879-0631

pii

0024-3205(90)90066-Z

journal_volume

46

pub_type

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