Abstract：
:Viperid, elapid and crotalid snake venoms were screened in vitro for antiviral activity against Sendai virus. The hemolysis of 10(8) human erythrocytes in 1 ml, caused by 70 HAU of Sendai virus, was abolished when the virions were pretreated with 10 ug of the viperid venom of Echis coloratus, and was considerably diminished when pretreated with 10 ug of the venom of Echis carinatus sochureki, the cobra venoms of Naja atra and Naja nigricollis nigricollis. These venoms did not affect the erythrocytes but inhibited the virions themselves irreversibly. All other examined snake venoms had low or no antiviral activity. There was no correlation between the proteolytic and the antiviral activity of the venoms.
journal_name
Life Scijournal_title
Life sciencesauthors
Borkow G,Ovadia Mdoi
10.1016/0024-3205(92)90015-hsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
1261-7issue
16eissn
0024-3205issn
1879-0631pii
0024-3205(92)90015-Hjournal_volume
51pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Castration increases the central nervous system (CNS) sensitivity to hexobarbital as measured by an EEG-threshold method. Testosterone treatment in doses from 1 to 5 mg/kg/day decreases CNS-sensitivity and restores threshold values in castrated rats to a level found in normal young adult male rats. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90385-6
更新日期：1985-03-11 00:00:00
abstract：:A variety of chromatographic approaches are detailed for enhancement of signal and selectivity for determination of biogenic amines by HPLC with amperometric detection. Microbore HPLC columns offer significant signal enhancement due to the reduced elution volume. Selection of novel surfactants such as N-methyl oleoyl ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90189-5
更新日期：1987-08-17 00:00:00
abstract：:The effects of muscarinic and alpha-adrenergic receptor stimulation on phosphoinositide turnover in rat atria have been compared. Despite the similar densities of muscarinic receptors in rat left and right atria, 0.1 mM carbachol increased [32P]phosphate incorporation into phosphatidylinositol (PI) by 35% (p less than...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90171-1
更新日期：1984-10-01 00:00:00
abstract：AIMS:MicroRNA-1 (miR-1) has been demonstrated as a tumor-suppressive miRNA, which shows a down-regulated pattern in several human malignancies including hepatocellular carcinoma (HCC). However, the pathophysiologic roles of miR-1 and their mechanisms in HCC tumorigenesis are still not totally elucidated. MAIN METHODS:...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.08.015
更新日期：2012-10-05 00:00:00
abstract：:Myelin basic protein and phosphatidylinositol-4-phosphate are phosphorylated in vitro by ATP and solubilized rat brain myelin. When both substrates are present together, the rate of phosphorylation of each is increased about eight-fold. It appears likely that the phosphate turnover of myelin basic protein and of phosp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90597-6
更新日期：1984-01-16 00:00:00
abstract：AIMS:Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, has been reported to be a novel marker for the progression of chronic kidney disease (CKD). We have recently found that accumulation of ADMA could trigger peritubular capillary loss, thus contributing to tubulointerstitial ischemia ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.03.018
更新日期：2009-06-05 00:00:00
abstract：AIMS:Ischemia-reperfusion (I/R) event in vascular and nervous system has been documented to rising ischemic and vasculitic neuropathic pain, clinically resembles the complex regional pain syndrome (CRPS). The present study evaluated the effect of montelukast, a cysteinyl leukotriene receptor (Cys-LTC(4) and Cys-LTD(4))...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.03.010
更新日期：2012-05-22 00:00:00
abstract：:ACE and chymase play crucial roles in the establishment of pressure overload-induced cardiac hypertrophy. In the present study, time sequences of ACE and chymase-like activities, and their correlation with hypertrophic changes including free wall thickness and cardiac fibrosis, were elucidated in dogs with constant pr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.04.006
更新日期：2004-07-16 00:00:00
abstract：AIMS:slc26a proteins are responsible for a large number of functions either in normal physiology or in human disease. We have previously reported that proximal tubular epithelial (PTE) cells immortalized from spontaneously hypertensive rats (SHRs) were endowed with increased Cl(-)/HCO3(-) exchanger activity and slc26a6...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.07.026
更新日期：2013-10-06 00:00:00
abstract：:We have developed an assay for serotonin (5-HT) stimulation of adenylate cyclase activity in membranes from adult guinea pig hippocampus. The response to 5-HT is concentration-dependent, with an EC50 of 0.01 microM, a shallow slope, and mean maximal stimulation of 90% over basal activity. The response to 5-HT is GTP-d...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90763-4
更新日期：1983-05-16 00:00:00
abstract：AIMS:Uric acid nephropathy (UAN) is due to excessive uric acid, which leads to hyperuricemia and kidney damage via the deposition of urate microcrystals in the kidneys. Iridoid glycosides of Paederia scandens (IGPS) is a major active component isolated from the traditional Chinese herb P. scandens (LOUR.) MERRILL (Rubi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.08.013
更新日期：2012-10-05 00:00:00
abstract：AIMS:This study's purpose was to evaluate the effect of ultrasound in air at a frequency of 0.04MHz and an intensity of 50mW/cm2 on neural differentiation of hBM-MSCs in vitro and on neurogenesis in an ischemic stroke model. MATERIALS AND METHODS:hBM-MSCs were exposed to 0.04MHz ultrasound and then compared with no ex...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.08.029
更新日期：2016-11-15 00:00:00
abstract：:Despite the lack of knowledge of the effects of electronic cigarettes (e-cigarettes, e-cigs) on public health, they have been proposed as a part of smoking cessation efforts. Recently, several basic scientific studies have pointed out how e-cigs can generate carcinogens, such as e-cig liquid thermal degradation by-pro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.04.059
更新日期：2019-07-01 00:00:00
abstract：:Adrenocortical activity varies on a circannual basis with increased secretion in the winter and decreased secretion in the summer. One consequence of this variation is a circannual pattern in immune function. Adrenal corticosteroids, especially glucocorticoids, depress cellular immune function and seem to be more effe...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(83)90767-1
更新日期：1983-05-16 00:00:00
abstract：:The effects of a newly synthesized compound, 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)-2(1H)-quinolinone (OPC-4392), on tyrosine hydroxylation in situ and in vitro were studied using rat striatal slices and tyrosine hydroxylase (TH) purified from bovine adrenal medulla, respectively. OPC-4392 dose-dependently i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90644-3
更新日期：1988-01-01 00:00:00
abstract：:The leukotriene (LT) synthesis inhibitors BAY x1005 and MK-886 were evaluated in human lung parenchyma challenged with an anti-IgE. The anti-IgE-induced LTE4 release was time- and dose-dependent. Treatment of the parenchyma with indomethacin (3 microM) prior to anti-IgE challenge inhibited the 6-keto prostaglandin F1 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00426-2
更新日期：1996-01-01 00:00:00
abstract：:The present study was designed to investigate the effects of chronic administration of the alcoholic extract of Terminalia arjuna (TAAE) bark on isoproterenol induced myocardial injury. The TAAE was administered orally to Wistar albino rats (150-200 g) in three different doses, by gastric gavage [3.4 mg/kg: (T1), 6.75...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00671-4
更新日期：2003-10-10 00:00:00
abstract：:Following a report that nortriptyline was found useful in the control of enuresis in adults, presumably as an anticholinergic, its likely mechanism of action and apparent bladder specificity have now been investigated in vitro. The ratios of anticholinergic potencies (reciprocal of dissociation contents, Ki) for four ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90093-2
更新日期：1987-05-04 00:00:00
abstract：:Extracts of brain and heart from rats at birth and postnatal days 2 and 10 were evaluated for naltrexone following maternal injection of 50 mg/kg opioid antagonist throughout gestation. Samples were prepared by ultrafiltration, lyophilized, reconstituted in mobile phase, and separated by reversed-phase high performanc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01090-4
更新日期：1998-01-01 00:00:00
abstract：:Muscarinic agonists elicit contraction in the standard guinea pig ileum bioassay through activation of M3 muscarinic receptors that are also linked to phosphoinositide hydrolysis. Surprisingly, the most abundant muscarinic receptor in the ileum is the M2 which causes a specific inhibition of cyclic AMP accumulation el...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(94)00035-q
更新日期：1995-01-01 00:00:00
abstract：AIMS:This experiment investigated the effects of sub-chronic aluminum chloride (AlCl3) exposure on rat ovaries. MAIN METHODS:Eighty female Wistar (5weeks old) rats, weighed 110-120g, were randomly divided into four treatment groups: control group (CG), low-dose group (LG, 64mg/kg BW AlCl3), mid-dose group (MG, 128mg/k...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.01.081
更新日期：2014-03-28 00:00:00
abstract：AIMS:The present study aimed to investigate the mechanism of bone repair mediated by recombination BMP-2 (rhBMP-2)/recombination CXC chemokine ligand-13 (rhCXCL13)-loaded hollow hydroxyapatite (HA) microspheres/chitosan (CS) composite. MATERIALS AND METHODS:Firstly, the biological activity of rhBMP-2 and rhCXCL13 rele...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116743
更新日期：2019-10-01 00:00:00
abstract：AIMS:Dyslipidemia-associated diabetic retinopathy is featured by macular edema and retinal angiogenesis. This study investigated the in vitro lipotoxicity of free fatty acids and their modulatory roles in regulation of autophagy and angiogenic factor production in cultured human retinal pigment epithelium (RPE) ARPE-19...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118391
更新日期：2020-10-15 00:00:00
abstract：:Mitochondria play a crucial role in the induction and execution of apoptosis. Accordingly, recent suggestions have been made to use agents that directly act on mitochondria to trigger apoptosis so that drug-sensitive and-resistant tumour cells can be eliminated. To test this hypothesis, human hepatocarcinoma HepG2 and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02103-3
更新日期：2002-10-25 00:00:00
abstract：AIM:Ethanol is one of the most widely used recreational drugs in the world. At high concentrations, it can induce carotid artery vasoconstriction. Hyperthermia potentiates its effects resulting in carotid artery vasoconstriction at any concentration. The aim of this study is to investigate the interaction between ethan...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.08.037
更新日期：2017-11-01 00:00:00
abstract：:Lewis rats were trained to self-stimulate the medial forebrain bundle (MFB) using a rate-frequency paradigm. They were then tested for the effects of the cannabinoid receptor agonist CP 55,940, the selective cannabinoid receptor antagonist SR 141716 and the dopamine D1 receptor antagonist SCH 23390. CP 55,940 (0, 10, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01366-2
更新日期：2001-11-21 00:00:00
abstract：:The influence of prior incubation on [3H]tryptamine binding was investigated in rat brain synaptic plasma membranes. A 55 min preincubation of the membranes at 37 degrees C induced an approx. 2.4-fold increase in the specific binding of [3H]ligand to the subsequently washed preparations and this phenomenon was quite t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90428-5
更新日期：1986-04-07 00:00:00
abstract：AIMS:This study aims to investigate the value of the expression of miR-208, miR-494, miR-499 and miR-1303 in the early diagnosis of acute myocardial infarction (AMI). MAIN METHODS:Patients were divided into two groups: AMI group (n = 41), and Stable angina pectoris (SAP) group (n = 32). Peripheral venous blood was sam...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116547
更新日期：2019-09-01 00:00:00
abstract：:The mechanism by which benzoate enhances total nitrogen excretion was investigated in-situ and in separated rat renal proximal tubules. Orally administered benzoate augmented NH4+, urea and hippurate excretion 2, 1.9 and 76 fold respectively, as compared to baseline for control. Hippurate had similar effects. Benzoate...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90086-q
更新日期：1991-01-01 00:00:00
abstract：:P75(NTR) is a common neurotrophin receptor which binds all neurotrophins with similar affinities and has been shown to be capable of mediating programmed cell death. In this study, we investigated effects of the antipsychotic drugs (APDs) haloperidol, clozapine, quetiapine, and risperidone on p75(NTR) mRNA levels in P...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.01.039
更新日期：2006-07-04 00:00:00
