Abstract：
:Chlorin e(6) and its derivatives are promising sensitizers for photodynamic therapy (PDT). In order to compare the photodynamic effects of 8 novel derivatives of chlorin e(6) and to explore some mechanisms of their effects at the cellular level, we studied PDT-induced changes in bioelectric activity of crayfish mechanoreceptor neuron that was used as a sensitive experimental model. Neurons were insensitive to red laser irradiation (632.8 nm; 0.3 W/cm(2)) or to photosensitizers alone, but changed firing rate and died under the photodynamic effect of nanomolar concentrations of sensitizers. The dynamics of neuron responses depended on photosensitizer type and concentration. The dependence of neuron lifetime on photosensitizer concentration allowed comparing efficiencies of different photosensitizers. Radachlorin was the most potent photosensitizer comparable with mTHPC. High photodynamic efficiency of some chlorin e(6) derivatives was related to weak dependence of neuron lifetime on sensitizer concentration, indicating to the initiation of 2-3 secondary processes such as free radical membrane damage by one absorbed photon. Photodynamic efficiency of sensitizers depended on amphiphilicity influencing their intracellular localization.
journal_name
Life Scijournal_title
Life sciencesauthors
Uzdensky AB,Dergacheva OY,Zhavoronkova AA,Reshetnikov AV,Ponomarev GVdoi
10.1016/j.lfs.2003.09.053subject
Has Abstractpub_date
2004-03-12 00:00:00pages
2185-97issue
17eissn
0024-3205issn
1879-0631pii
S0024320503011640journal_volume
74pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 receptors (a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90609-f
更新日期：1991-01-01 00:00:00
abstract：:Neurotensin (NT) administered intracerebroventricularly (i.c.v.) to rats, blocks intestinal transit (tested by charcoal meal) in linear relation to the log of the doses within the range of 0.6-2.5 nmoles/rat. NT in this test is about 40 times more active than morphine (M) and 6 times less active than dermorphin (DM) o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90547-7
更新日期：1983-01-01 00:00:00
abstract：AIMS:We tested the hypothesis that an in vivo gene delivery of the pro-survival protein XIAP (X-chromosome linked inhibitor of apoptosis protein) protects against myocardial apoptosis and infarction following ischemia/reperfusion. MAIN METHODS:Nineteen rabbits were chronically instrumented with a hydraulic occluder pl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.01.019
更新日期：2011-03-28 00:00:00
abstract：:3H-Flunitrazepam (FNZP) binding was examined in a crude membrane fraction obtained from rat interscapular brown adipose tissue (IBAT). A single population of binding sites was apparent with dissociation constant (KD) = 0.47 +/- 0.04 microM and maximal number of binding sites (Bmax) = 31 +/- 5 pmol.mg prot-1. From the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90077-x
更新日期：1988-01-01 00:00:00
abstract：:Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitoch...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(91)90440-m
更新日期：1991-01-01 00:00:00
abstract：:Acyl glucuronides are reactive electrophilic metabolites of carboxylate drugs, capable of undergoing hydrolysis, rearrangement and covalent binding reactions with proteins in vivo. Such covalent drug-protein adducts may be prerequisites for certain idiosyncratic immune and toxic responses in susceptible individuals. T...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00958-9
更新日期：2000-12-22 00:00:00
abstract：:CGS 10746B, a benzothiadiazepine, has a behavioral profile in mice and monkeys similar to the atypical antipsychotic clozapine. Unlike clozapine, CGS 10746B suppresses dopamine neuron firing rates and, when administered at behaviorally effective doses by the oral or intraperitoneal route, decreases neostriatal dopamin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90017-2
更新日期：1986-08-25 00:00:00
abstract：:Tricyclic antidepressant drugs bind to histamine receptors in rodent and other mammalian tissues. However, a readily accessible, normal human tissue for studies of these drugs has not been available. We showed that freshly isolated human leukocytes can be used for this purpose. Following isolation by dextran sedimenta...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90441-7
更新日期：1984-12-17 00:00:00
abstract：:A variety of chromatographic approaches are detailed for enhancement of signal and selectivity for determination of biogenic amines by HPLC with amperometric detection. Microbore HPLC columns offer significant signal enhancement due to the reduced elution volume. Selection of novel surfactants such as N-methyl oleoyl ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90189-5
更新日期：1987-08-17 00:00:00
abstract：AIMS:Evidence has indicated U50,488H, a selective κ-opioid receptor (κ-OR) agonist, administered before ischemia attenuates apoptosis and infarction during ischemia and reperfusion (I/R). However, it remains unclear whether U50,488H postconditioning reduces apoptosis during I/R. This study was designed, therefore, to t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.10.018
更新日期：2011-01-03 00:00:00
abstract：AIMS:Antenatal glucocorticoid therapy has been shown to prevent acute diseases including infant respiratory distress syndrome and reduce mortality, although little is known about the effects on cardiac function-related proteins in the fetus or neonate. We investigated whether cardiac function-related proteins were alte...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.06.017
更新日期：2009-10-21 00:00:00
abstract：:In canine renal tubular cells, the effect of Y-24180, a presumed specific platelet activating factor (PAF) receptor antagonist, on intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured by using fura-2 as a Ca(2+)-sensitive fluorescent probe. Y-24180 (0.1-10 microM) caused a rapid and sustained [Ca(2+)](i) rise...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.09.033
更新日期：2004-01-02 00:00:00
abstract：AIMS:This study's purpose was to evaluate the effect of ultrasound in air at a frequency of 0.04MHz and an intensity of 50mW/cm2 on neural differentiation of hBM-MSCs in vitro and on neurogenesis in an ischemic stroke model. MATERIALS AND METHODS:hBM-MSCs were exposed to 0.04MHz ultrasound and then compared with no ex...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.08.029
更新日期：2016-11-15 00:00:00
abstract：:Antroduodenal myoelectric activity was recorded in conscious sheep by electrodes chronically implanted in the muscular wall. Furthermore, plasma immunoreactive (i.r.) motilin, somatostatin and bombesin concentrations were determined by RIA. The intravenous infusion of somatostatin (20 ng/kg/min), bombesin (10 ng/kg/mi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00209-3
更新日期：1996-01-01 00:00:00
abstract：:TNF production has been studied in peritoneal macrophages and splenic T cells of Arctic Yakutian ground squirrel (Citellus Undulatus Pallas) in hibernating and awake animals in winter and in prehibernating autumn as well as in active euthermic spring-summer animals. A high level of TNF production in macrophages of gro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00698-6
更新日期：2000-01-01 00:00:00
abstract：:The scientific interest in irisin, a myokine discovered in 2012, has grown exponentially in recent years. Irisin, which is mainly produced in skeletal muscle, influences the browning process of adipose tissue and lipid and energy metabolism. Recent discoveries highlight that the potential of this hormone may have been...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118954
更新日期：2021-02-15 00:00:00
abstract：:The effects of social crowding in rats on nociception and analgesic actions of mu- and kappa-opioid agonists agonist qualitatively different stimuli were examined. Crowding produced higher control thresholds for electroshock and paw pinch pressure but not for noxious heat. Naloxone did not effect shock thresholds in c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90345-9
更新日期：1982-09-20 00:00:00
abstract：:This study was designed to document possible changes in bupivacaine and its main metabolite, des-butyl-bupivacaine (PPX) kinetics in mice after a single 5 mg/kg injection of diltiazem. After a single 20 mg/kg i.p. dose of bupivacaine, kinetic parameters of bupivacaine were not statistically different but the ratio AUC...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00601-6
更新日期：1994-01-01 00:00:00
abstract：:Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potent...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.05.021
更新日期：2018-07-15 00:00:00
abstract：:SARS-CoV-2 infection or COVID-19 has become a worldwide pandemic; however, effective treatment for COVID-19 remains to be established. Along with acute respiratory distress syndrome (ARDS), new and old cardiovascular injuries are important causes of significant morbidity and mortality in COVID-19. Exploring new approa...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2021.119130
更新日期：2021-01-26 00:00:00
abstract：:The retina contains three catecholamine neurotransmitters: dopamine (DA); norepinephrine (NE); and epinephrine (EPI). DA and EPI appear to be associated with separate amacrine neurons that directly participate in the visual process. NE, in contrast, appears to be associated primarily with the sympathetic nerves that i...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(84)90184-x
更新日期：1984-09-10 00:00:00
abstract：:Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118847
更新日期：2021-02-01 00:00:00
abstract：:Vanadate has been suggested as an intracellular regulator of (Na+ + K+)-ATPase. To test this hypothesis we examined the stimulatory and inhibitory effects of vanadate on 86--Rb efflux and influx (measurements of the activity of the Na-pump) in rat ileum under conditions of normal, reduced and increased (Na+ + K+)-ATPa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90486-9
更新日期：1988-01-01 00:00:00
abstract：:Hypoxic preconditioning (HPC) has been well demonstrated to have potent protective effects in many cell types; however, the mechanisms responsible for this phenomenon are not fully understood. Recently, glucose-regulated protein 78 (GRP78), an inducible molecular chaperon, was indicated to be associated with ischemic ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.08.015
更新日期：2007-09-08 00:00:00
abstract：:Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90333-5
更新日期：1988-01-01 00:00:00
abstract：:We examined whether H(+)-ATPase is involved in the control of cellular action of arginine vasopressin (AVP) to produce adenosine 3', 5'-monophosphate (cAMP) and mobilize cellular free calcium ([Ca2+]i) in rat renal papillary collecting tubule cells in culture. N-Ethylmaleimide (NEM), an inhibitor of H(+)-ATPase, reduc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90594-s
更新日期：1993-01-01 00:00:00
abstract：:Recently, 4.4'-bis(1-p-carboxyphenyl-3-methyl-5-dydroxyl)-pyrazol (DRD156) has been developed as a new sensitive reagent that reacts specifically with singlet oxygen. The specificity of DRD156 for singlet oxygen in a biomimetic solution (micellar solution) and the effects of its coexistence with other reagent were exa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02234-8
更新日期：2002-12-06 00:00:00
abstract：:Antinociceptive effect of nifedipine (15 mg/kg i.p.) and verapamil (10 mg/kg s.c.) was examined in rats chronically exposed to nicotine (6 mg/kg/day via Alzet osmotic pump for 28 days) and after nicotine withdrawal. Sham operated rats served as control for testing DMSO (dimethylsulfoxide, a solvent for nifedipine), ni...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00107-0
更新日期：1997-01-01 00:00:00
abstract：:We studied the effect of interleukin-1 alpha (IL-1) on corticotropin-releasing hormone (CRH) secretion by explanted rat hypothalami in vitro. We also assessed possible mediation of arachidonic acid metabolites on IL-1-stimulated CRH secretion, by preincubating hypothalami with the cyclooxygenase inhibitor indomethacin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90190-3
更新日期：1990-01-01 00:00:00
abstract：:The in vitro and in vivo regulation of [3H]Ro 5-4864 binding to peripheral benzodiazepine receptors (PBR) by ion transport/exchange inhibitors was studied in the kidney. The potencies of 9-anthroic acid, furosemide, bumetanide, hydrochlorothiazide and SITS as inhibitors of [3H]Ro 5-4864 binding to renal membranes were...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90464-x
更新日期：1988-01-01 00:00:00
