Changes in high affinity sodium independent gamma-aminobutyric acid binding in cerebral cortex and hippocampus of the rat following electroshock.

abstract：:To evaluate the relative contributions of the ovarian inhibin and estradiol-17 beta (E) on the regulation of FSH secretion, inhibin and E in ovarian venous plasma (OVP) and FSH and LH in peripheral plasma were simultaneously measured using superovulating rats with special reference to follicular maturation. By the tra...

journal_title：Life sciences

authors： Tsukamoto I,Taya K,Watanabe G,Sasamoto S

更新日期：1986-07-14 00:00:00

abstract：:Neem seed preparations contain not only azadirachtin as the active insect antifeedant or growth regulator but also a variety of their limonoids, some of which are cytotoxic to N1E-115 neuroblastoma (mouse), 143B.TK- osteosarcoma (human) and Sf9 (insect) cultured cell lines. The most potent of these limonoids is nimbol...

journal_title：Life sciences

authors： Cohen E,Quistad GB,Casida JE

更新日期：1996-01-01 00:00:00

abstract：:The temperature effects of naloxone and naltrexone (1-30 mg/kg) were examined in well habituated male rats. These drugs had a similar time course and potency, producing a dose-dependent hypothermia followed several hours later by a hyperthermia. A subsequent study found that not only did 30 mg/kg of naloxone or naltre...

journal_title：Life sciences

authors： Eikelboom R

更新日期：1987-03-16 00:00:00

abstract：AIMS:To evaluate vagal stimulation-mediated myocardial protection against ischemia and reperfusion in in vivo ischemic myocardium. MAIN METHODS:We measured myocardial interstitial myoglobin levels in the ischemic region using a cardiac microdialysis technique in anesthetized and vagotomized cats. We occluded the left ...

journal_title：Life sciences

authors： Kawada T,Yamazaki T,Akiyama T,Kitagawa H,Shimizu S,Mizuno M,Li M,Sugimachi M

更新日期：2008-09-26 00:00:00

abstract：:Previous studies indicated that exogenous dopamine and its agonists directly regulated mitogen-induced immune cell proliferation. In this study, we further investigated role of endogenous dopamine in immune cell growth. Haloperidol, a general antagonist for dopamine receptors, could reduce the cell growth rate of T ce...

journal_title：Life sciences

authors： Tsao CW,Lin YS,Cheng JT

更新日期：1998-01-01 00:00:00

abstract：:Patients with neurogenic orthostatic hypotension due to multiple system atrophy (MSA) or pure autonomic failure (PAF) excrete lower amounts of homovanillic acid (HVA) than do normal subjects. There is a highly significant correlation between the rates of excretion of HVA and norepinephrine metabolites. The regression ...

journal_title：Life sciences

authors： Kopin IJ,Oliver JA,Polinsky RJ

更新日期：1988-01-01 00:00:00

abstract：:In order to explore the effect of neonatal androgen administration on oocyte quality, ovulation induction and in vitro fertilization (IVF) were performed in androgen-sterilized mice. Androgen sterilized mice were produced by the subcutaneous injection of testosterone propionate (TP) at 5 days of age and ovulation indu...

journal_title：Life sciences

authors： Kamijo T,Mizunuma H,Yamada K,Ibuki Y

更新日期：1994-01-01 00:00:00

abstract：:The potential effect of maternal caffeine ingestion upon total brain protein and the concentration of two prototype neuropeptides, thyrotropin-releasing hormone (TRH) and its derivative, cyclo (His-Pro) in neonates was examined during the nursing period in the context of variable maternal protein intake. Maternal caff...

journal_title：Life sciences

authors： Mori M,Wilber JF,Nakamoto T

更新日期：1983-11-21 00:00:00

abstract：:Vanadate has been suggested as an intracellular regulator of (Na+ + K+)-ATPase. To test this hypothesis we examined the stimulatory and inhibitory effects of vanadate on 86--Rb efflux and influx (measurements of the activity of the Na-pump) in rat ileum under conditions of normal, reduced and increased (Na+ + K+)-ATPa...

journal_title：Life sciences

authors： Hajjar JJ,Rowe WA,Tomicic TK

更新日期：1988-01-01 00:00:00

abstract：:LH stimulation is mediated by its own receptor at the first step of the cascade, after which intracellular cAMP increases to stimulate the transcription of steroidogenic acute regulatory protein (StAR) in mouse MA-10 Leydig tumor cells. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of ...

journal_title：Life sciences

authors： Tsuchiya M,Inoue K,Matsuda H,Nakamura K,Mizutani T,Miyamoto K,Minegishi T

更新日期：2003-10-17 00:00:00

abstract：:The aim of the study was to assess how the interruption of enterohepatic circulation may affect the regulation of apolipoprotein synthesis. For this purpose, apolipoprotein mRNA levels were measured in the liver and small intestine of male Wistar rats fed for 3 weeks diets with or without cholestyramine (5% w/w). In o...

journal_title：Life sciences

authors： Felgines C,Mazur A,Rayssiguier Y

更新日期：1994-01-01 00:00:00

abstract：:We hypothesized that the atheroinhibitory and cardioprotective effects of estrogen may be mediated in part through increased prostacyclin formation by the artery wall. Atherosclerotic abdominal aorta was collected at necropsy from ovariectomized female monkeys fed an atherogenic diet alone or with added Premarin. Basa...

journal_title：Life sciences

authors： O'Sullivan MG,Goodrich JA,Adams MR

更新日期：2001-06-15 00:00:00

abstract：AIMS:Lung cancer represents as the most prevalent tumor globally, among which non-small cell lung cancer (NSCLC) takes up for more than 80%. Lysine demethylase 4A (KDM4A) was dysregulated in NSCLC, but its role on the tumorigenesis in NSCLC cells and the mechanisms of actions are unclear. In this work, we evaluated its...

journal_title：Life sciences

authors： Sun S,Yang F,Zhu Y,Zhang S

更新日期：2020-12-01 00:00:00

abstract：:Alpha2-adrenoceptor (alpha2-AR)-regulated binding of the labelled GTP analog, guanosine 5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS), to guanine-nucleotide-binding proteins (G proteins) was studied in human platelet membranes. Under optimal conditions, the potent alpha2-AR agonist, 5-bromo-6-(2-imidazolin-2-ylamino...

journal_title：Life sciences

authors： Gessi S,Campi F,Varani K,Borea PA

更新日期：1999-01-01 00:00:00

abstract：:Coffee is consumed worldwide with greater than a billion cups of coffee ingested every day. Epidemiological studies have revealed an association of coffee consumption with reduced incidence of a variety of chronic diseases as well as all-cause mortality. Current research has primarily focused on the effects of coffee ...

journal_title：Life sciences

authors： Dirks-Naylor AJ

更新日期：2015-12-15 00:00:00

abstract：:Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute liver injury mediated by reactive oxygen species (ROS) as normal metabolites in hepatocytes. In this study, the molecular process in this type of liver injury was analyzed from the aspect of liver function and regulatory factor...

journal_title：Life sciences

authors： Taniguchi M,Takeuchi T,Nakatsuka R,Watanabe T,Sato K

更新日期：2004-08-13 00:00:00

abstract：AIMS:The pulmonary vasodilation induced by adrenomedullin may be beneficial in the acute pulmonary embolism (APE) setting. This study examined effects of adrenomedullin in sheep with microsphere-induced APE. MAIN METHODS:Twenty four anesthetized, mechanically ventilated sheep were randomly assigned into 3 groups (n=8 ...

journal_title：Life sciences

authors： Lagos-Carvajal AP,Teixeira-Neto FJ,Becerra-Velásquez DR,Diniz MS,Klein AV,Rocha TL,Dias-Junior CA

更新日期：2015-10-15 00:00:00

abstract：:N(G)-Nitro-L-arginine methyl ester (L-NAME), inhibits the three isozymes of nitric oxide synthase (NOS) in vitro and in vivo. The mechanism of NOS inhibition by L-NAME is uncertain. L-NAME was a time-dependent inhibitor of neuronal NOS (nNOS). Concommitantly, L-NAME was hydrolyzed, non-enzymatically, to N(G)-Nitro-L-a...

journal_title：Life sciences

authors： Furfine ES,Carbine K,Bunker S,Tanoury G,Harmon M,Laubach V,Sherman P

更新日期：1997-01-01 00:00:00

abstract：AIM:Muscle atrophy is a common symptom after nerve denervation. Myostatin propeptide, a precursor of myostatin, has been documented to improve muscle growth. However, the mechanism underlying the muscle atrophy attenuation effects of myostatin propeptide in muscles and the changes in gene expression are not well establ...

journal_title：Life sciences

authors： Tsai SW,Tung YT,Chen HL,Yang SH,Liu CY,Lu M,Pai HJ,Lin CC,Chen CM

更新日期：2016-02-01 00:00:00

abstract：:Orthodontic tooth movement induced alveolar bone resorption and formation around the teeth applied mechanical force. Although mechanical force can promote bone formation, the molecular mechanism that underlies this phenomenon is not fully understood. The purposes of this study were to determine how mechanical stress a...

journal_title：Life sciences

authors： Mitsui N,Suzuki N,Maeno M,Yanagisawa M,Koyama Y,Otsuka K,Shimizu N

更新日期：2006-05-01 00:00:00

abstract：:Retinoic acids and their cognate nuclear receptors exert a substantial regulatory role in cell growth and development as well as in the neuroendocrine system. These effects are primarily mediated by all-trans retinoic acid receptors (RARs), members of the steroid/thyroid hormone receptor superfamily of ligand inducibl...

journal_title：Life sciences

authors： Brtko J,Knopp J,Kvetnanský R

更新日期：2000-03-24 00:00:00

abstract：:The regions of muscarinic receptors that specify G-protein-coupling and ligand-binding have been defined in several recent studies. Overall, these studies have shown that amino acids within the third cytoplasmic loop of the receptors define their selectivity for different G-proteins, and that multiple, discontinuous e...

journal_title：Life sciences

authors： Brann MR,Klimkowski VJ,Ellis J

更新日期：1993-01-01 00:00:00

abstract：:Three distinct peptidyldipeptidases (exopeptidases releasing carboxyl terminal dipeptide residues) can be solubilized from nerve terminal membrane fractions from whole rat brain or striatum, and separated by ion exchange chromatography. Brain angiotensin-converting enzyme (PDP-1) cleaves Hip-His-Leu, but not 80 nM [3H...

journal_title：Life sciences

authors： Cushman DW,Gordon EM,Wang FL,Cheung HS,Tung R,Delaney NG

更新日期：1983-01-01 00:00:00

abstract：:Clinical studies of cholinergic pharmacotherapy, together with the putative role of the muscarinic receptor system in the neurophysiology of human behavior, support a possible muscarinic cholinergic involvement in schizophrenia. The present study has measured the density of [3H]AF-DX 384 labelled receptors (muscarinic...

journal_title：Life sciences

authors： Crook JM,Dean B,Pavey G,Copolov D

更新日期：1999-01-01 00:00:00

abstract：:Hyperketonemia has been identified as an important factor in diabetic pregnancy affecting growth and development of the offspring. In order to assess the immediate metabolic alterations in embryos caused by excess ketone bodies, we studied rat embryonic neural tissue exposed to a high concentration of beta-hydroxybuty...

journal_title：Life sciences

authors： Yang X,Borg LA,Eriksson UJ

更新日期：1998-01-01 00:00:00

abstract：:The content of lactic acid in red blood cells, plasma, and Ehrlich ascites tumor cells were measured by a gas-liquid chromatography using a column with a terephtalic acid support coated with polyethylene glycol-6000. The lactic acid contents were directly determined in aqueous samples, because they were converted to a...

journal_title：Life sciences

authors： Kageyama K,Onoyama Y,Nakajima T,Tumura M,Nishida T,Kogawa H,Tanabe K

更新日期：1992-01-01 00:00:00

abstract：:Static sense organs composed of a hollow statocyst surrounded by sensory hairs and containing aggregate bodies (statoliths) have been detected in various species of Vespinae. On the frons in the groove traversing its center (the frontal groove) there is a deep pit and around it a membrane enclosing a cyst-like sac. In...

journal_title：Life sciences

authors： Ishay JS,Shimony T,Arcan L

更新日期：1983-04-11 00:00:00

abstract：:1-oleoyl-2-acetyl glycerol (OAG), a potent activator of protein kinase C, inhibited the binding of 125I-labelled epidermal growth factor (EGF) in isolated rat pancreatic acini. Unlike cholecystokinin-octapeptide (CCK8) and the C-kinase activator 12-O-tetradecanoyl phorbol-13-acetate (TPA), two inhibitors of 125I-EGF e...

journal_title：Life sciences

authors： Brockenbrough JS,Korc M

更新日期：1987-04-20 00:00:00

abstract：AIMS:The aim of this work was to examine the antitumor effects and mechanisms of M4IDP, a zoledronic acid derivative, on human colorectal cancer (CRC) HCT116 cells. MAIN METHODS:The effects of M4IDP on proliferation, cell cycle and ROS production were determined by CCK-8 and flow cytometry assays. Annexin-V-FITC/PI, H...

journal_title：Life sciences

authors： Peng Y,Qiu L,Xu D,Zhang L,Yu H,Ding Y,Deng L,Lin J

更新日期：2017-09-15 00:00:00

abstract：:We investigated the role of sensory nerves in glucose tolerance in conscious Wistar rats neonatally treated with neurotoxin capsaicin or vehicle. Intravenous glucose tolerance tests (IVGTT, 150, 300 and 450 mg in 30 min) were performed to measure glucose tolerance, and glucose, insulin and glucagon levels were measure...

journal_title：Life sciences

authors： van de Wall EH,Gram DX,Strubbe JH,Scheurink AJ,Koolhaas JM

更新日期：2005-07-29 00:00:00