Intrarenal conversion of big endothelin-1 to endothelin-1 in the rat.

abstract：:Vascular disease is one of the complicating features of diabetes mellitus. Magnesium deficiency has recently been proposed as a novel factor implicated in the pathogenesis of diabetes complications. Several studies have indicated that hypertension in diabetic patients is an independent altered reaction of blood vessel...

journal_title：Life sciences

authors： Soltani N,Keshavarz M,Sohanaki H,Dehpour AR,Zahedi Asl S

更新日期：2005-02-11 00:00:00

abstract：:Current therapy for type 1 diabetes mellitus involves a daily regimen of multiple subcutaneous or intramuscular injections of recombinant human insulin. To achieve long-term insulin delivery in vivo, we investigated the applicability of cytomedical therapy using beta TC6 cells or MIN6 cells, both of which are murine p...

journal_title：Life sciences

authors： Suzuki R,Okada N,Miyamoto H,Yoshioka T,Sakamoto K,Oka H,Tsutsumi Y,Nakagawa S,Miyazaki J,Mayumi T

更新日期：2002-08-30 00:00:00

abstract：:The Thirteenth International Conference on Endothelin (ET-13) was held from September 8-11, 2013 in Tokyo, Japan chaired by Noriaki Emoto, Kobe Pharmaceutical University, Japan, and Takashi Miyauchi, University of Tsukuba, Japan and held on the Tokyo Campus of Tsukuba University. The International Conferences on Endot...

journal_title：Life sciences

authors： Emoto N,Yanagisawa M

更新日期：2014-11-24 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) has a neurotrophic effect both in vitro and in vivo, and is considered to play an important role in the maintenance of neuronal functions in the normal brain. Neural damage in brain contusion progresses after the primary injury of trauma because of cerebral hemodynamic and metabol...

journal_title：Life sciences

authors： Iwamoto Y,Yamaki T,Murakami N,Sugawa N,Yoshino E,Ueda S,Nosaka K,Nishino H,Iwashima A

更新日期：1994-01-01 00:00:00

abstract：:The effects of methyl vitamin B12 (5-6 mg/kg, p.o.) on the entrainment of circadian running wheel activity rhythm to a new lighting schedule were measured in rats. After the light-dark (LD) cycle was abruptly reversed, rats given vitamin B12 took less time to entrain their circadian locomotor activity rhythm to the ne...

journal_title：Life sciences

authors： Tsujimaru S,Ida Y,Satoh H,Egami H,Shirao I,Mukasa H,Nakazawa Y

更新日期：1992-01-01 00:00:00

abstract：:Hypotensive responses to tryptophan and 5-hydroxytryptophan infusions were studied in normotensive male Sprague-Dawley rats. Results showed that 5-hydroxytryptophan but not tryptophan lowered pressure in a dose dependent way in direct relation to the production of brain serotonin and 5-HIAA. Intrinsic release of serot...

journal_title：Life sciences

authors： Freed CR,Echizen H,Bhaskaran D

更新日期：1985-11-11 00:00:00

abstract：:Alpha adrenergic agonists and antagonists as clonidine, guanfacine, yohimbine, phenylephrine and prazosin inhibited the [3H]-QNB binding to rat brain cortex muscarinic acetylcholine receptor (mAChR, M-1 subtype), heart (M-2 subtype) and parotid gland homogenate (M-3 subtype) in a dose-dependent competitive fashion. Ki...

journal_title：Life sciences

authors： Simon G,Filep J,Zelles T

更新日期：1990-01-01 00:00:00

abstract：:Angiotensin (AII) and atrial natriuretic peptide (ANP) exert opposite effects on phosphorylation of a 17.6 kDa nuclear protein from bovine adrenal glomerulosa cells. The protein was separated by sodium dodecyl sulfate electrophoresis and blotted onto polyvinylidene difluoride, and the N-terminal sequence was obtained....

journal_title：Life sciences

authors： Elliott ME

更新日期：1990-01-01 00:00:00

abstract：:The effect of 32 mM ascorbate on the time courses of phosphocreatine (PCr), inorganic phosphate (Pi), adenosine triphosphate (ATP) and intracellular pH in rat skeletal muscle during ischemia and reperfusion was investigated in vivo using 31P nuclear magnetic resonance (NMR) spectroscopy. Ascorbate was administered int...

journal_title：Life sciences

authors： Lagerwall K,Daneryd P,Scherstén T,Soussi B

更新日期：1995-01-01 00:00:00

abstract：:Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitoch...

journal_title：Life sciences

authors： Costa E,Guidotti A

更新日期：1991-01-01 00:00:00

abstract：:An increase in the weight of the thyroid gland, accompanied by reductions in uptake and release of 1311, serum T3 and reverse T3 concentrations and an increase in serum TSH concentration, occurs during the development of renal hypertension in rats. Renal function, as assessed by BUN, serum and urinary creatinine conce...

journal_title：Life sciences

authors： Fregly MJ,Threatte RM

更新日期：1982-02-15 00:00:00

abstract：:Ketamine, used clinically as an intravenous analgetic and dissociative anaesthetic agent, is a racemate with both pharmacokinetic and pharmacodynamic enantioselectivity. S-ketamine has been found have a higher clearance and greater potency than R-ketamine as well as a greater therapeutic index. We performed a study in...

journal_title：Life sciences

authors： Edwards SR,Mather LE

更新日期：2001-09-14 00:00:00

abstract：:SGK1 is one of the protein-serine/threonine kinases that is activated by insulin in a PI3K-dependent manner. Although SGK1 mediates a variety of biological activities, the mechanisms regulating its activity remain unclear. In this study, we examined the potential roles of calcium signaling in the activation of SGK1. T...

journal_title：Life sciences

authors： Imai S,Okayama N,Shimizu M,Itoh M

更新日期：2003-04-04 00:00:00

abstract：AIMS:Chemo-resistance still was the main obstacle for AML patients, more effective and less toxic forms of therapies were desperately needed. Metformin, a classic hypoglycemic drug for diabetes recently delivered us a new identity that it exerted anti-tumor activity through suppressing mTOR in various tumors. But the a...

journal_title：Life sciences

authors： Yuan F,Cheng C,Xiao F,Liu H,Cao S,Zhou G

更新日期：2020-02-15 00:00:00

abstract：:Different receptors mediating the release of endothelium-derived nitric oxide (EDNO) have been identified at endothelial level. In the present study we aimed to characterise, on rabbit aorta by means of pharmacological tools, the generation of EDNO by receptors located on endothelial cell membrane (M3, P2u, P2y) and b...

journal_title：Life sciences

authors： Chinellato A,Froldi G,Caparrotta L,Ragazzi E

更新日期：1998-01-01 00:00:00

abstract：:To understand the leptin's action on hypothalamic arcuate nucleus (ARC), Ca2+/calmodulin (CaM)-dependent response in leptin-treated rat ARC was investigated. The in vitro phosphorylation of ARC extracts from leptin-treated rats did not respond to CaM. Although CaM-dependent protein kinase II activity was not affected ...

journal_title：Life sciences

authors： Morishita T,Hidaka T,Sugahara K,Noguchi T

更新日期：1998-01-01 00:00:00

abstract：AIMS:Prior work suggests that ischemic preconditioning increases the level of CD39 in the heart and contributes to cardiac protection. Therefore, we examined if targeted cardiac expression of CD39 protects against myocardial injury. MAIN METHODS:Mice with cardiac-specific expression of human CD39 (αMHC/hCD39-Tg) were ...

journal_title：Life sciences

authors： Smith SB,Xu Z,Novitskaya T,Zhang B,Chepurko E,Pu XA,Wheeler DG,Ziolo M,Gumina RJ

更新日期：2017-06-15 00:00:00

abstract：AIMS:The mechanism of cough hypersensitivity induced by particulate matter 2.5 (PM2.5) remains elusive. The current study was designed to explore the effect of transient receptor potential vanilloid-1 (TRPV1) on cough hypersensitivity in airway and central nervous system. MAIN METHODS:The PM2.5-induced chronic cough m...

journal_title：Life sciences

authors： Lv H,Yue J,Chen Z,Chai S,Cao X,Zhan J,Ji Z,Zhang H,Dong R,Lai K

更新日期：2016-04-15 00:00:00

abstract：:Arsenic as a one of the most important toxic metals could induce hepatotoxicity. Previous reports revealed the significance of oxidative stress in promoting of arsenic-induced liver toxicity. The aim of the present investigation is to evaluate the effect of chrysin (CHR), a natural flavonoid with potent antioxidant ac...

journal_title：Life sciences

authors： Fatemi I,Khalili H,Mehrzadi S,Basir Z,Malayeri A,Goudarzi M

更新日期：2021-02-15 00:00:00

abstract：:Karyopherin α2 (KPNA2, also known as importinα-1), a member of the nuclear transporter family, is involved in the nucleocytoplasmic transport pathway of a variety of tumor-associated proteins. Recent studies have found that KPNA2 is overexpressed in various cancers, which is associated with poor prognosis. In addition...

journal_title：Life sciences

authors： Han Y,Wang X

更新日期：2020-01-15 00:00:00

abstract：:Increased oxidative stress plays a role in the pathogenesis of beta-cell dysfunction and death. We studied isoforms of NADPH oxidase components in islets of Langerhans isolated from rat pancreas and tumoral rat beta-cell line RINm5F cells by RT-PCR and sequencing of its products. RT-PCR revealed that isolated islets c...

journal_title：Life sciences

authors： Uchizono Y,Takeya R,Iwase M,Sasaki N,Oku M,Imoto H,Iida M,Sumimoto H

更新日期：2006-12-14 00:00:00

abstract：:Adrenocortical activity varies on a circannual basis with increased secretion in the winter and decreased secretion in the summer. One consequence of this variation is a circannual pattern in immune function. Adrenal corticosteroids, especially glucocorticoids, depress cellular immune function and seem to be more effe...

journal_title：Life sciences

authors： MacMurray JP,Barker JP,Armstrong JD,Bozzetti LP,Kuhn IN

更新日期：1983-05-16 00:00:00

abstract：AIMS:Changes in cardiac autonomic nervous function have been evaluated by studying the related indexes of heart rate variability (HRV) in patients with focal epilepsy (FE) in the interictal period. MAIN METHODS:A total of 30 FE patients who were treated in our department from July 2015 to May 2017, were included into ...

journal_title：Life sciences

authors： Yu YL,Li NN,Shi MT,Lu HJ

更新日期：2018-09-15 00:00:00

abstract：:We conducted a study to determine whether angiotensin converting enzyme inhibitors (ACEIs) inhibit endothelin secretion from cultured human endothelial cells. Confluent umbilical vein endothelial cells were incubated in multi-well plates with culture medium containing either captopril (10(-6), 10(-5), 10(-4) M) or ena...

journal_title：Life sciences

authors： Yoshida H,Nakamura M

更新日期：1992-01-01 00:00:00

abstract：AIMS:Hyperphosphatemia is an independent risk factor of cardiovascular events in the patients with chronic kidney disease. High phosphate can induce endothelial cell apoptosis, but the exact mechanism is not clear. This study fills this knowledge gap. MATERIALS AND METHODS:Microarray analysis was used to identify diff...

journal_title：Life sciences

authors： Qin L,Tang B,Deng B,Mohan C,Wu T,Peng A

更新日期：2015-06-15 00:00:00

abstract：AIMS:High level of saturated fatty acids leads to mitochondrial dysfunction and inflammation in the development of insulin resistance in skeletal muscle. We recently found that puerarin improved impaired insulin signaling in skeletal muscle in diabetic animals and in myotubes in vitro. However, whether puerarin can act...

journal_title：Life sciences

authors： Chen X,Yi L,Song S,Wang L,Liang Q,Wang Y,Wu Y,Gao Q

更新日期：2018-08-01 00:00:00

abstract：:Homocysteine (Hcy), an intermediate in methionine metabolism, has been proposed to be involved in hepatic fibrogenesis. Impaired liver function can alter Hcy metabolism. The aim of the present study was to determine plasma Hcy alterations in acute obstructive cholestasis and the subsequent biliary cirrhosis. Cholestas...

journal_title：Life sciences

authors： Ebrahimkhani MR,Sadeghipour H,Dehghani M,Kiani S,Payabvash S,Riazi K,Honar H,Pasalar P,Mirazi N,Amanlou M,Farsam H,Dehpour AR

更新日期：2005-04-08 00:00:00

abstract：:To evaluate possible deleterious effects of commonly used herbicides on leukocytes, cytokine production was selected as a sensitive indicator. After in vitro exposure of human peripheral blood mononuclear cells from normal donors, the production of all 3 cytokines tested--interferon-gamma (a type 1 cytokine), interleu...

journal_title：Life sciences

authors： Hooghe RJ,Devos S,Hooghe-Peters EL

更新日期：2000-05-19 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic, and HAM/TSP...

journal_title：Life sciences

authors： Fuzii HT,da Silva Dias GA,de Barros RJ,Falcão LF,Quaresma JA

更新日期：2014-05-28 00:00:00

abstract：:"Bath salts" is one street name for a family of synthetic cathinones that display pharmacological effects resembling cocaine and commonly abused amphetamines. Despite extensive legislation aimed at the criminalization of bath salts, several designer cathinones are gaining a foothold in the illicit drug scene; for exam...

journal_title：Life sciences

authors： Gregg RA,Rawls SM

更新日期：2014-02-27 00:00:00