当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Leptin changes Ca2+/calmodulin-dependent response and up-regulates the gene expression of calcineurin in rat hypothalamus.

Leptin changes Ca2+/calmodulin-dependent response and up-regulates the gene expression of calcineurin in rat hypothalamus.

Abstract：

:To understand the leptin's action on hypothalamic arcuate nucleus (ARC), Ca2+/calmodulin (CaM)-dependent response in leptin-treated rat ARC was investigated. The in vitro phosphorylation of ARC extracts from leptin-treated rats did not respond to CaM. Although CaM-dependent protein kinase II activity was not affected by leptin, the gene expression of calcineurin, CaM-dependent phosphatase, increased in leptin-treated rats.

journal_name

Life Sci

journal_title

Life sciences

authors

Morishita T,Hidaka T,Sugahara K,Noguchi T

doi

10.1016/s0024-3205(98)00460-3

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

PL311-5

issue

20

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(98)00460-3

journal_volume

63

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Subcellular fractionation of striatum: sedimentation properties of dopaminergic synaptosomes.

    abstract：:Linear sucrose density gradient centrifugation of a crude synaptosomal-mitochondrial preparation of rat striatum was performed at 82,500g for 7.5, 15 and 30 min and 1, 4 and 20 h. After centrifugation various marker enzyme activities were measured throughout the gradients, viz. tyrosine hydroxylase (TH) and DOPA decar...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90248-5

    authors： Van der Krogt JA,Koot-Gronsveld E,Van den Berg CJ

    更新日期：1983-08-15 00:00:00

  • Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet: Neurotrophin content and protein kinase activity.

    abstract：AIMS:The purpose of this study was to determine a relatively short-term effect of feeding an α-linolenic acid (ALA, n-3)-restricted, linoleic acid (LA, n-6)-adequate diet on neurotrophin contents and protein kinase activities in brain regions of the mouse. MAIN METHODS:After feeding mice a safflower oil (SAF) diet (AL...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2010.09.003

    authors： Miyazawa D,Yasui Y,Yamada K,Ohara N,Okuyama H

    更新日期：2010-10-09 00:00:00

  • Meconium-induced lung injury mediated by activation of alveolar macrophages.

    abstract：:To clarify the mechanism of meconium-induced cellular injury, we examined the effect of meconium on the alveolar macrophages (AM) and bronchial epithelial cells (AK-D). Meconium obtained from healthy newborns was added to culture medium of AM and/or AK-D, which were cultured for 1 hour. Superoxide anion production of ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)90026-4

    authors： Kojima T,Hattori K,Fujiwara T,Sasai-Takedatsu M,Kobayashi Y

    更新日期：1994-01-01 00:00:00

  • Developmental changes of testicular activin and FSH receptor mRNA and plasma FSH and inhibin levels in the rat.

    abstract：:To investigate the changes in the FSH receptor and the activin receptor during sexual maturation in rat testes, we examined the mRNA levels of the receptors by Northern blot analysis. With a full length rat activin receptor cRNA probe in this study, Northern blot analysis revealed two activin receptor mRNAs (6Kb and 3...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90575-n

    authors： Ito I,Minegishi T,Hasegawa Y,Shinozaki H,Nakamura K,Igarashi S,Nakamura M,Miyamoto K,Ibuki Y

    更新日期：1993-01-01 00:00:00

  • Phorbol esters, but not the hormonal form of vitamin D, induce changes in protein kinase C during differentiation of human histiocytic lymphoma cell line (U-937).

    abstract：:Human histiocytic lymphoma cells (U-937) undergo similar differentiation when incubated with the phorbol ester 12-0-tetradecanoyl phorbol-13-acetate (TPA) and 1,25-dihydroxycholecalciferol. In this action, TPA somehow implicates calcium-sensitive and phospholipid-dependent protein kinase (protein kinase C), which is r...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90105-6

    authors： Mezzetti G,Bagnara GP,Monti MG,Pernecco Casolo L,Bonsi L,Brunelli MA

    更新日期：1987-05-25 00:00:00

  • The appropriate remodeling of extracellular matrix is the key molecular signature in subcutaneous adipose tissue following Roux-en-Y gastric bypass.

    abstract：AIMS:We sought to reveal the key molecular signature in subcutaneous adipose tissue (scAT) following Roux-en-Y gastric bypass (RYGB), through bioinformatics analysis and further verification in vivo. MAIN METHODS:We obtained a transcriptome data of scAT from RYGB and sham-operated rats from the Gene Expression Omnibus...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.12.051

    authors： Chen X,Gong L,Li Q,Hu J,Liu X,Wang Y,Bai J,Ran X,Wu J,Ge Q,Li R,Xiao X,Li X,Zhang J,Wang Z

    更新日期：2019-02-01 00:00:00

  • Reduction of stress-induced analgesia following ethanol exposure in mice.

    abstract：:In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress-induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, i.p.) or an equal volume of saline once a day for two days. Animals received no treatment on...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00328-2

    authors： Bell RL,Soignier RD,Olson RD,Vaccarino AL

    更新日期：1998-01-01 00:00:00

  • Alpha 1-adrenoceptors in human prostate: characterization and binding characteristics of alpha 1-antagonists.

    abstract：:The role of alpha 1-adrenoceptors in the mediation of autonomic functions, particularly in the control of the cardiovascular system, is widely known. It has been shown that alpha 1-adrenoceptors localized in human prostate mediate the contraction of prostatic smooth muscles which produces an increase in the intraureth...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0024-3205(94)90141-4

    authors： Yamada S,Tanaka C,Kimura R,Kawabe K

    更新日期：1994-01-01 00:00:00

  • Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclear cells.

    abstract：AIMS:To evaluate potential agents of therapeutic value in tissue inflammation, we studied norcantharidin (NCTD) and its derivatives for their effects on immune responses of human peripheral blood mononuclear cells (PBMC) in vitro. MAIN METHODS:PBMC proliferation was evaluated by tritiated thymidine uptake method. The ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2008.11.020

    authors： Chen YC,Chang SC,Wu MH,Chuang KA,Wu JY,Tsai WJ,Kuo YC

    更新日期：2009-02-13 00:00:00

  • Characterization of homogeneous atrial granule serine proteinase, a candidate processing enzyme of pro-atrial natriuretic factor.

    abstract：:We previously reported the discovery and partial characterization of bovine atrial granule serine proteinase, a candidate processing enzyme of pro-atrial natriuretic factor, which is associated with atrial granule membranes. We now report the physicochemical properties of electrophoretically homogeneous enzyme purifie...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90392-3

    authors： Wypij DM,Harris RB

    更新日期：1992-01-01 00:00:00

  • Protective effect of a molecular chaperone inducer, paeoniflorin, on the HCl- and ethanol-triggered gastric mucosal injury.

    abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2010.12.014

    authors： Asai M,Kawashima D,Katagiri K,Takeuchi R,Tohnai G,Ohtsuka K

    更新日期：2011-02-14 00:00:00

  • Nuclear all-trans retinoic acid receptor status in rat liver: a comparison of effects of three different stressors--immobilization, laparotomy, and 2-deoxy-D-glucose.

    abstract：:Retinoic acids and their cognate nuclear receptors exert a substantial regulatory role in cell growth and development as well as in the neuroendocrine system. These effects are primarily mediated by all-trans retinoic acid receptors (RARs), members of the steroid/thyroid hormone receptor superfamily of ligand inducibl...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00496-3

    authors： Brtko J,Knopp J,Kvetnanský R

    更新日期：2000-03-24 00:00:00

  • Nkx2.5 enhances the efficacy of mesenchymal stem cells transplantation in treatment heart failure in rats.

    abstract：AIMS:The aim of this study is to determine whether Nkx2.5 transfection of transplanted bone marrow mesenchymal stem cells (MSCs) improves the efficacy of treatment of adriamycin-induced heart failure in a rat model. MAIN METHODS:Nkx2.5 was transfected in MSCs by lentiviral vector transduction. The expressions of Nkx2....

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.06.014

    authors： Deng B,Wang JX,Hu XX,Duan P,Wang L,Li Y,Zhu QL

    更新日期：2017-08-01 00:00:00

  • Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice.

    abstract：:Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118847

    authors： Bastaki S,Aravindhan S,Ahmadpour Saheb N,Afsari Kashani M,Evgenievich Dorofeev A,Karoon Kiani F,Jahandideh H,Beigi Dargani F,Aksoun M,Nikkhoo A,Masjedi A,Mahmoodpoor A,Ahmadi M,Dolati S,Namvar Aghdash S,Jadidi-Niaragh F

    更新日期：2021-02-01 00:00:00

  • Inhibition by talipexole, a thiazolo-azepine derivative, of dopaminergic neurons in the ventral tegmental area.

    abstract：:A microiontophoretic study using rats anesthetized with chloral hydrate and immobilized with gallamine triethiodide was carried out to compare the effect of talipexole (B-HT 920 CL2:2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo [4,5-d]-azepine-dihydrochloride), a dopamine autoreceptor agonist, on dopaminergic neurons...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90071-i

    authors： Momiyama T,Sasa M,Takaori S

    更新日期：1991-01-01 00:00:00

  • Renal glutathione homeostasis in compensatory renal growth.

    abstract：:Glutathione homeostasis was investigated in unilaterally nephrectomized and sham-operated rats. Following twelve days of compensatory renal growth, it was found that the concentrations of glutathione and glutathione disulfide in representative samples of the entire remnant right kidney from the nephrectomized rats wer...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90132-4

    authors： Zalups RK,Veltman JC

    更新日期：1988-01-01 00:00:00

  • Effects of ischemia on cholinergic neurotransmission and electrolyte content in newborn pig lumbar spinal cord.

    abstract：:The biochemical changes of the elements of cholinergic neurotransmission (choline acetyltransferase, ChAT; acetylcholinesterase, AChE; butyrylcholinesterase, BuChE; and muscarinic cholinergic receptors, mAChR) as well as the electrolyte content were studied in ischemic lumbar spinal cord segments of newborn pigs. Isch...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90069-4

    authors： Tekulics P,Rakonczay Z,Szerdahelyi P,Kása P,Gulya K

    更新日期：1990-01-01 00:00:00

  • Effects of subacute treatment with cocaine on activities of N-demethylase, UDP-glucuronyltransferase and sulfotransferase in WKY and SHR rat liver--sex and strain differences.

    abstract：:The effects of subacute treatment with cocaine on activities of cocaine N-demethylase, UDP-glucuronyltransferase (GT) toward 4-nitrophenol and phenolphthalein and sulfotransferase (ST) toward androsterone and 4-nitrophenol in livers from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigat...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90626-1

    authors： Watanabe HK,Hoskins B,Ho IK

    更新日期：1988-01-01 00:00:00

  • Psychobiological factors related to human natural killer cell activity and hormonal modulation of NK cells in vitro.

    abstract：:The present report investigated whether percentages of circulating natural killer (NK) cells and NK cell activity (NKCA) are associated with psychological variables. Subjects (n = 95) were selected, based on a combination of low or high scores on questionnaires on daily hassles and self-reported symptoms, to create fo...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90002-k

    authors： Benschop RJ,Jabaaij L,Oostveen FG,Vingerhoets AJ,Kirschbaum C,Duivenvoorden HJ,Ballieux RE

    更新日期：1993-01-01 00:00:00

  • Agomelatine affects rat suprachiasmatic nucleus neurons via melatonin and serotonin receptors.

    abstract：AIMS:The hypothalamic suprachiasmatic nucleus (SCN), which functions as a circadian pacemaker in mammals, is influenced by melatonin and serotonin. Agomelatine, which acts as an antidepressant and can synchronize disturbed circadian rhythms, displays a unique mechanism of action involving both melatonergic agonist and ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.04.035

    authors： Yang J,Jin HJ,Mocaër E,Seguin L,Zhao H,Rusak B

    更新日期：2016-06-15 00:00:00

  • Mancozeb-induced genotoxicity and apoptosis in cultured human lymphocytes.

    abstract：AIMS:Mancozeb is a dithiocarbamate fungicide known to be genotoxic and induces tumors in rodents at various sites. There is no report in the literature about its genotoxicity in humans. Here, we investigated the association between mancozeb exposure and induction of genotoxic and proapoptotic changes in cultured human ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2011.12.013

    authors： Srivastava AK,Ali W,Singh R,Bhui K,Tyagi S,Al-Khedhairy AA,Srivastava PK,Musarrat J,Shukla Y

    更新日期：2012-06-06 00:00:00

  • Streptozotocin induced hyperglycemia stimulates molecular signaling that promotes cell cycle reentry in mouse hippocampus.

    abstract：AIMS:Cerebral atrophy resulting from neurodegeneration is highly prevalent in individuals with diabetes; however, the underlying mechanisms for diabetic neurodegeneration are not fully understood. Here we hypothesized that hyperglycemia induces molecular signaling that favors induction of proliferation in post mitotic,...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.05.019

    authors： Yang E,Gavini K,Bhakta A,Dhanasekaran M,Khan I,Parameshwaran K

    更新日期：2018-07-15 00:00:00

  • Neutralizing IL-6 reduces heart injury by decreasing nerve growth factor precursor in the heart and hypothalamus during rat cardiopulmonary bypass.

    abstract：AIMS:To investigate whether the expression of nerve growth factor precursor (proNGF) changes during cardiopulmonary bypass (CPB) and whether neutralizing interleukin-6 (IL-6) during CPB has cardiac benefits. MAIN METHODS:Thirty patients undergoing CPB were recruited and their serum proNGF and troponin-I (TNI) were det...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.04.007

    authors： Cheng C,Xu JM,Yu T

    更新日期：2017-06-01 00:00:00

  • Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis.

    abstract：AIMS:Naturally-derived farnesol has been reported for its chemopreventive and chemotherapeutic efficacy in various cancers. However, the mechanism of action of farnesol is still to be elucidated. The present study demonstrates the chemopreventive potential of farnesol on 9,10-dimethylbenz(a)anthracene (DMBA)-initiated ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2009.05.008

    authors： Chaudhary SC,Alam MS,Siddiqui MS,Athar M

    更新日期：2009-07-31 00:00:00

  • Molecular mechanisms of interplay between autophagy and metabolism in cancer.

    abstract：:Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how auto...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2020.118184

    authors： Raj S,Chandel V,Kumar A,Kesari KK,Asthana S,Ruokolainen J,Kamal MA,Kumar D

    更新日期：2020-10-15 00:00:00

  • Adrenalectomy increases norepinephrine turnover in brown adipose tissue of obese (ob/ob) mice.

    abstract：:The hyperphagia and rapid body weight gain normally observed in young obese (ob/ob) mice were abolished by removal of their adrenal glands, whereas food intake and weight gain of lean mice were not significantly affected by adrenalectomy. Adrenalectomy lowered body energy density (kcal/g carcass) in obese mice more th...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90056-0

    authors： Vander Tuig JG,Ohshima K,Yoshida T,Romsos DR,Bray GA

    更新日期：1984-04-09 00:00:00

  • pH and thermo dual stimulus-responsive liposome nanoparticles for targeted delivery of platinum-acridine hybrid agent.

    abstract：:The complexes of the type [PtCl(L2)(ACRAMTU)](NO3)2 (ACRAMTU = 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea) were synthesized: PT-ACRAMTU (1), L2 = ethane-1,2-diamine (en); PT(dach)-ACRAMTU (2), L2 = (1R,2R)-1,2-diaminocyclohexane (dach); PT(pda-OH)-ACRAMTU (3), L2 = 2-hydroxy-1,3-propanediamine (pda-OH). The c...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.11.052

    authors： Zhou Q,You C,Ling Y,Wu H,Sun B

    更新日期：2019-01-15 00:00:00

  • Identification of endothelin converting enzyme in bovine lung membranes using a new fluorogenic substrate.

    abstract：:An enzyme partially purified from bovine lung membranes appears to be endothelin converting enzyme (ECE). This enzyme specifically cleaves big endothelin-1 (big ET-1) at the proper site, between Trp21 and Val22, with maximum activity at pH 7.5 and with a Km of roughly 3 microM, to produce endothelin-1 (ET-1) and C-ter...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90175-o

    authors： Kundu GC,Wilson IB

    更新日期：1992-01-01 00:00:00

  • Protective effect of XY99-5038 on hydrogen peroxide induced cell death in cultured retinal neurons.

    abstract：:XY99-5038 is a preparation from a specific formula provided by Dr. Yan Xin, a renowned Traditional Chinese Medicine specialist. This formulation has proven to be effective without side effects but has not been studied under rigorous laboratory conditions. In order to investigate the role of XY99-5038 in protecting neu...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01122-5

    authors： Xin Y,Fong YT,Wolf G,Wolf D,Cao W

    更新日期：2001-06-08 00:00:00

  • Effect of transient receptor potential vanilloid-1 on cough hypersensitivity induced by particulate matter 2.5.

    abstract：AIMS:The mechanism of cough hypersensitivity induced by particulate matter 2.5 (PM2.5) remains elusive. The current study was designed to explore the effect of transient receptor potential vanilloid-1 (TRPV1) on cough hypersensitivity in airway and central nervous system. MAIN METHODS:The PM2.5-induced chronic cough m...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.02.064

    authors： Lv H,Yue J,Chen Z,Chai S,Cao X,Zhan J,Ji Z,Zhang H,Dong R,Lai K

    更新日期：2016-04-15 00:00:00