Abstract：
:This study examined the protective effect of phenobarbital on kainic acid-induced deficits in acquisition learning. A single kainic acid injection (9 mg/kg i.p.) was administered five days prior to testing using the Morris water maze test. Kainic acid produced deficits in the acquisition of spatial information observed as an increase in latency to a hidden escape platform. Daily phenobarbital treatment (20 mg/kg i.p.) initiated 45 minutes prior to the kainic acid injection blocked the kainic acid-induced deficits in acquisition learning. When daily phenobarbital treatment was initiated 2-3 hours after kainic acid seizure development it did not block the kainic acid induced-deficits in water maze performance. Daily administration of phenobarbital alone at the moderate concentration used in this study did not cause alterations in behavioral performance in the Morris water maze. These studies indicate that phenobarbital pre-treatment results in a behavioral neuroprotection against kainic acid-induced neurotoxicity.
journal_name
Life Scijournal_title
Life sciencesauthors
Brown-Croyts LM,Caton PW,Radecki DT,McPherson SLdoi
10.1016/s0024-3205(00)00658-5subject
Has Abstractpub_date
2000-06-30 00:00:00pages
643-50issue
6eissn
0024-3205issn
1879-0631pii
S0024-3205(00)00658-5journal_volume
67pub_type
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