Abstract：
:Following severe thermal injury, patients are resistant to non-depolarizing muscle relaxants. Although this resistance has been well documented clinically, little is known about its etiology. We have tested the hypothesis that circulating factors contribute to the decreased potency of neuromuscular blockers following burns. The potencies of d-tubocurarine (2 microM) or pancuronium (2 microM) dissolved in plasma from either burned or control human subjects were tested on the indirectly stimulated (0.2 Hz) rat phrenic nerve-hemidiaphragm preparation. The muscle relaxants produced less neuromuscular blockade when dissolved in plasma from burned patients than when they were dissolved in plasma from controls. Thus, circulating factors are involved in the decreased potency of non-depolarizing neuromuscular blocking drugs.
journal_name
Life Scijournal_title
Life sciencesauthors
Storella RJ,Martyn JA,Bierkamper GGdoi
10.1016/0024-3205(88)90234-2subject
Has Abstractpub_date
1988-01-01 00:00:00pages
35-40issue
1eissn
0024-3205issn
1879-0631pii
0024-3205(88)90234-2journal_volume
43pub_type
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