A newly discovered xenobiotic metabolic pathway: ethyl ester formation.

abstract：AIMS:Centella asiatica has been used to treat kidney diseases in Chinese traditional medicine. Asiaticoside (an extraction of C. asiatica) exerts a variety of pharmacological effects including immunomodulatory and anti-inflammatory functions. However, the mechanism of asiaticoside in the treatment of renal diseases rem...

journal_title：Life sciences

authors： Wang Z,Liu J,Sun W

更新日期：2013-09-03 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), an adrenal steroid of no known biological function, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). DHEA inhibited the growth of two stains of HeLa and WI-38 cells in culture. One of the HeLa strains, TCRC-2, was about 10x as sensitive to growth inhibition a...

journal_title：Life sciences

authors： Dworkin CR,Gorman SD,Pashko LL,Cristofalo VJ,Schwartz AG

更新日期：1986-04-21 00:00:00

abstract：:We have examined the role of membrane hyperpolarization in mediating vascular hyporeactivity induced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat thoracic aorta ex vivo. The injection of rats with LPS caused a significant fall of blood pressure and a severe vascular hyporeactivity to nore...

journal_title：Life sciences

authors： Chen SJ,Wu CC,Yang SN,Lin CI,Yen MH

更新日期：2000-12-29 00:00:00

abstract：:Collagen is the most abundant protein in mammalian systems; it can be found in organs such as bones, the liver, kidney, heart, teeth, and skin. Collagen provides the necessary structural framework for tissues in which it is found. However, if there are any alterations in the delicate balance of collagen types in the e...

journal_title：Life sciences

authors： Kisling A,Lust RM,Katwa LC

更新日期：2019-07-01 00:00:00

abstract：:Catecholamine uptake into PC12 cells, in the presence and absence of ATP, was measured in a bicarbonate-buffered Krebs Ringer. ATP enhanced significantly the uptake in a dose-dependent manner with maximal uptake at 1-3 mM. ATP increased the Vmax of uptake by 3-5 fold for both dopamine and norepinephrine, without a sig...

journal_title：Life sciences

authors： Eshleman A,Dunigan C,Shamoo A,Eldefrawi M

更新日期：1995-01-01 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) is a proliferative disorder characterized by enhanced proliferation and suppressed apoptosis of intrapulmonary vascular smooth muscle cells. Recently, network-based bioinformatics have identified let-7 family, a tumor suppressive microRNA, regulate multiple interacting targets relevant ...

journal_title：Life sciences

authors： Zhang WF,Xiong YW,Zhu TT,Xiong AZ,Bao HH,Cheng XS

更新日期：2017-02-01 00:00:00

abstract：AIMS:To investigate the effects of curcumin on alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease (COPD) and its potential mechanism. MAIN METHODS:The rat COPD model was established by cigarette smoke exposure combined with intratracheal administration of lipopolysaccharide. Thirty-eigh...

journal_title：Life sciences

authors： Zhang M,Xie Y,Yan R,Shan H,Tang J,Cai Y,Yin J,Chen M,Zhang J,Yang X,Zhang Q,Li Y

更新日期：2016-11-01 00:00:00

abstract：:Tobacco smoke exposure has been shown to inhibit brain and platelet MAO B in animals and in humans. Though the mechanism(s) responsible for MAO B inhibition are not known, studies in rodents have shown that nicotine administration does not inhibit brain MAO B. In this study we investigated whether brain MAO B is also ...

journal_title：Life sciences

authors： Fowler JS,Volkow ND,Logan J,Pappas N,King P,MacGregor R,Shea C,Garza V,Gatley SJ

更新日期：1998-01-01 00:00:00

abstract：:Activation of the sympathetic system by phencyclidine (PCP) should result in catecholamine release from the adrenals. However, adrenalectomy does not reduce PCP-induced hypertension. In an attempt to rectify this inconsistency, the direct effects of PCP on the bovine adrenal medulla were examined. At (3 X 10(-6) M), P...

journal_title：Life sciences

authors： Malavé A,Borowitz JL,Yim GK

更新日期：1983-08-08 00:00:00

abstract：AIMS:Our overall objective was to investigate the effect of the adenosine derivative 2',3',5'-tri-O-acetyl-N6-(3-hydroxylaniline) adenosine (WS010117) on AMP-activated protein kinase (AMPK) activation and lipid metabolism and to also assess the underlying mechanisms involved in these processes. MAIN METHODS:HepG2 cell...

journal_title：Life sciences

authors： Guo P,Lian ZQ,Sheng LH,Wu CM,Gao J,Li J,Wang Y,Guo YS,Zhu HB

更新日期：2012-01-02 00:00:00

abstract：:The effect of continuous treatment with the selective 5-HT1A agonist gepirone upon 5-HT2-mediated behavior and cortical 5-HT2 receptor binding sites was examined in naive rats or rats receiving noradrenergic (DSP4) or serotonergic (5,7-DHT) lesions. Continuous administration of gepirone in non-lesioned rats for 3, 7, ...

journal_title：Life sciences

authors： Yocca FD,Eison AS,Hyslop DK,Ryan E,Taylor DP,Gianutsos G

更新日期：1991-01-01 00:00:00

abstract：AIMS:Studies using transgenic mouse strains that incorporate Alzheimer's disease (AD) mutations are valuable for the identification of signaling pathways, potential drug targets, and possible mechanisms of disease that will aid in our understanding of AD. However, reports on the effects of specific AD mutations (Swedis...

journal_title：Life sciences

authors： Glazner KA,Odero GL,Anema E,Motnenko A,Schapansky J,Grossman D,Oliver DR,Glazner GW,Albensi BC

更新日期：2010-06-19 00:00:00

abstract：:DHEA improves insulin sensitivity and has anti-obesity effect in animal models and men. However, the molecular mechanisms by which DHEA improves insulin action have not been clearly understood. In the present study, we examined the protein levels and phosphorylation state of insulin receptor (IR), IRS-1 and IRS-2, the...

journal_title：Life sciences

authors： Campbell CS,Caperuto LC,Hirata AE,Araujo EP,Velloso LA,Saad MJ,Carvalho CR

更新日期：2004-11-19 00:00:00

abstract：:Hypertension is closely associated with vascular endothelial dysfunction. The aim of this study was to investigate the effects of Angiotensin II (ANG II) receptor antagonist losartan on the blood-brain barrier (BBB) permeability in L-NAME-induced hypertension and/or in ANG II-induced acute hypertension in normotensive...

journal_title：Life sciences

authors： Kucuk M,Kaya M,Kalayci R,Cimen V,Kudat H,Arican N,Elmas I,Korkut F

更新日期：2002-07-12 00:00:00

abstract：:The present study was conducted to characterize the binding of neurotransmitter receptors (dopamine D(2), serotonin 5-HT(2), histamine H(1), adrenaline alpha(1) and muscarine M(l) receptors) in the rat's brain after the oral administration of haloperidol, risperidone, and olanzapine. Haloperidol at 1 and 3 mg/kg displ...

journal_title：Life sciences

authors： Uchida S,Kato Y,Hirano K,Kagawa Y,Yamada S

更新日期：2007-04-03 00:00:00

abstract：:Juncusol, phenolic compound, was isolated from the black needlerush, Juncus roemerianus. Different concentrations of this extract were tested for toxicity against selected species of estuarine fish and grass shrimp. Juncusol was ten times more toxic to the various species of fish than to grass shrimp. At 2.0 ppm conce...

journal_title：Life sciences

authors： de la Cruz AA,Miles DH,Chapatwala KD

更新日期：1982-05-24 00:00:00

abstract：:The regulation of G protein-coupled receptor expression is important in the physiology of an organism and can occur at any of the steps between gene transcription to turnover of the receptor protein itself. Agonist stimulation causes receptor desensitization, which is characterized by a rapid reduction in response to ...

journal_title：Life sciences

authors： Heck DA,Bylund DB

更新日期：1998-01-01 00:00:00

abstract：:Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...

journal_title：Life sciences

authors： Roman-Campos D,Cruz JS

更新日期：2014-03-07 00:00:00

abstract：AIM:Cyclophosphamide (CYP) chemotherapy induces bladder toxicity and hemorrhagic cystitis in cancer patients constituting a current clinical concern. Oxidative inflammatory cascades have been implicated as the mechanism contributing to CYP bladder urotoxicity. We thus assayed to explore whether zinc (Zn) supplementatio...

journal_title：Life sciences

authors： Famurewa AC,Edeogu CO,Offor FI,Besong EE,Akunna GG,Maduagwuna EK

更新日期：2021-02-01 00:00:00

abstract：:Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone re...

journal_title：Life sciences

authors： Porreca F,Dray A

更新日期：1984-06-25 00:00:00

abstract：UNLABELLED:The present study was conducted to examine whether melatonin impairs serotonin (5HT) release and uptake in rat platelets. Exposure of platelet-rich plasma samples (PRP) to melatonin induced a concentration-dependent inhibition of 5HT uptake and the value of IC50 was 1.3 x 10(-3) M. We have also investigated ...

journal_title：Life sciences

authors： Martín FJ,Atienza G,Aldegunde M,Míguez JM

更新日期：1993-01-01 00:00:00

abstract：:Reportedly, excitatory amino acids are involved in the control of gonadotropin secretion of rats and non-human primates. The aim of this study was to investigate the effect of chronic blockade of NMDA (N-methyl-D-aspartic acid) receptors by the non competitive receptor antagonist MK-801 on gonadotropin secretion and t...

journal_title：Life sciences

authors： Veneroni O,Cocilovo L,Müller EE,Cocchi D

更新日期：1990-01-01 00:00:00

abstract：:Oxidative stress (free radical generation exceeds antioxidant defense) occurs in many diseases and after exposure to certain chemicals. We automated assays estimating the antioxidant status of serum and lipid hydroperoxide concentrations using the Syva-30R automated analyzer. In this assay, the antioxidant status of s...

journal_title：Life sciences

authors： Mahle C,Dasgupta A

更新日期：1997-01-01 00:00:00

abstract：:ACE and chymase play crucial roles in the establishment of pressure overload-induced cardiac hypertrophy. In the present study, time sequences of ACE and chymase-like activities, and their correlation with hypertrophic changes including free wall thickness and cardiac fibrosis, were elucidated in dogs with constant pr...

journal_title：Life sciences

authors： Orito K,Yamane T,Kanai T,Fujii Y,Wakao Y,Matsuda H

更新日期：2004-07-16 00:00:00

abstract：AIMS:Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. MAIN METHODS:Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assay...

journal_title：Life sciences

authors： Sogawa N,Hirai K,Sogawa C,Ohyama K,Miyazaki I,Tsukamoto G,Asanuma M,Sasaki A,Kitayama S

更新日期：2013-04-09 00:00:00

abstract：:Recent studies suggest lipopolysaccharide (LPS) mediated cell death as underlying mechanism of hyporesponsiveness and dysfunction of macrophages in the late phase of septic shock. In the present study LPS (0.001 - 30 microg/ml) caused a concentration-dependent toxicity in the macrophage cell line (J774.1A) within 24 h...

journal_title：Life sciences

authors： Abate A,Schröder H

更新日期：1998-01-01 00:00:00

abstract：:In order to better understand the mechanisms underlying the reduction in GH secretion in diabetic rats, we have characterized and measured SRIH receptors in the hypothalamus and anterior pituitary gland 5 and 9 days after induction of diabetes in the rat. Experimental diabetes was induced by an intraperitoneal injecti...

journal_title：Life sciences

authors： Pesce G,Guillaume V,Dutour A,Dadoun F,Joanny P,Steinberg J,Oliver C

更新日期：1994-01-01 00:00:00

abstract：:Although lipid peroxidation of biological samples may be assessed by different chemical and physical methods, those based on the measurement of malondialdehyde formed from the breakdown of endoperoxides during the last stages of the oxidation of a polyunsaturated fatty acid, appear as the most widely used. Among the v...

journal_title：Life sciences

authors： Valenzuela A

更新日期：1991-01-01 00:00:00

abstract：:Kainic acid (KA) is a potent convulsant which, when administered subcutaneously, induces sustained limbic seizures and a pattern of limbic brain damage that is thought to be seizure-mediated. Diazepam suppresses and morphine enhances both the seizures and brain damage induced by KA. Here we show that morphine enhancem...

journal_title：Life sciences

authors： Fuller TA,Olney JW,Conboy VT

更新日期：1982-07-19 00:00:00

abstract：:The ontogeny and regulation by isoproterenol of type II thyroxine 5'-deiodinase, N-acetyltransferase, and hydroxyindole-O-methyltransferase activities were studied in the rat Harderian gland. Both 5'-deiodinase and N-acetyltransferase activities exhibited maximal values at the first week of age. These activities gradu...

journal_title：Life sciences

authors： Osuna C,Rubio A,Goberna R,Guerrero JM

更新日期：1990-01-01 00:00:00