First demonstration of an inhibitory activity of milk proteins against human immunodeficiency virus-1 reverse transcriptase and the effect of succinylation.

abstract：:Autophagy is considered as an important intracellular mechanism that degrades cytoplasmic components to furnish additional energy. It has cytoprotective effects through the degradation of intracellular pathogens, damaged organelles, and protein aggregates. On the other hand, there are reports of an association between...

journal_title：Life sciences

authors： Karami J,Masoumi M,Khorramdelazad H,Bashiri H,Darvishi P,Sereshki HA,Shekarabi M,Sahebkar A

更新日期：2020-08-01 00:00:00

abstract：:A series of studies were conducted to determine the effects of leucine-(leu-) enkephalin and methionine-(met-) enkephalin on perfusion pressure. These experiments utilized isolated perfused femoral arterial preparations in pentobarbital-anesthetized cats. The enkephalins were administered intraarterially into the femo...

journal_title：Life sciences

authors： Moore RH 3rd,Dowling DA

更新日期：1982-10-11 00:00:00

abstract：:Platelet functions are becoming the useful tool for delineating the etiology of pregnancy induced hypertension. Electronmicroscopic studies, efflux and content of 5-HT in platelets and platelet aggregation responses towards various aggregating agents have been measured in 25 normotensive pregnant subjects and 31 PIH s...

journal_title：Life sciences

authors： Gujrati VR,Goyal A,Gaur SP,Singh N,Shanker K,Chandravati

更新日期：1994-01-01 00:00:00

abstract：:This study was designed to evaluate the effects of roxithromycin (RXM), a newly synthesized macrolide antibiotic on allergic responses in mice. RXM was orally administered into BALB/c mice once a day for 42 days in a single dose of 5 mg/kg body weight. Spleen cells (Sp C) collected from mice on day 7, 14, 28 and 42 po...

journal_title：Life sciences

authors： Konno S,Adachi M,Asano K,Okamoto K,Takahashi T

更新日期：1993-01-01 00:00:00

abstract：:1,25-dihydroxyvitamin D3 has important physiological effects such as calcium transport and cell growth and differentiation. These biological effects are mediated by their binding to specific intracellular receptor termed vitamin D receptor (VDR). VDR mRNA expression has been demonstrated in several tissues, but to dat...

journal_title：Life sciences

authors： Pérez-Fernandez R,Alonso M,Segura C,Muñoz I,García-Caballero T,Diguez C

更新日期：1997-01-01 00:00:00

abstract：:L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl. Haloperidol catalepsy was increased only by ivc histamine. H1 (but not H2) receptor antagonists have shown anticataleptic effect in the action of analgesics and haloperidol. ...

journal_title：Life sciences

authors： Malec D,Langwiński R

更新日期：1983-01-01 00:00:00

abstract：:An acute injection of an intoxicating dose of alcohol to male rats 24 hours prior to breeding with drug-naive females produced no discernible effect on copulatory activity, as reflected in vaginal plugs, but resulted in markedly (> 50%) reduced pregnancy rates. Fetal outcome was also markedly affected in offspring sir...

journal_title：Life sciences

authors： Cicero TJ,Nock B,O'Connor LH,Sewing BN,Adams ML,Meyer ER

更新日期：1994-01-01 00:00:00

abstract：:Carboxylesterase activity (EC 3.1.1.1) of hen brain including neurotoxic esterases NTEA and NTEB is solubilized from lyophilized lipid-extracted brain material by the use of n-octylglucoside. The solubilized enzymes are subjected to free isoelectric focusing, six carboxyl - esterase activity peaks are obtained. By gel...

journal_title：Life sciences

authors： Chemnitius JM,Haselmeyer KH,Zech R

更新日期：1984-03-19 00:00:00

abstract：:Based on our earlier animal study, we became interested to investigate if thromboxane A2 (TXA2) is involved in angiotensin converting enzyme (ACE) induced cough in man. To 11 patients with hypertension, who had developed cough induced by ACE inhibitors, a TXA2 synthetase inhibitor, ozagrel was given for 1 to 2 months ...

journal_title：Life sciences

authors： Umemura K,Nakashima M,Saruta T

更新日期：1997-01-01 00:00:00

abstract：AIMS:Salivary gland dysfunction is a common complication of diabetes mellitus (DM). Long non-coding RNA (lncRNA) is evidenced to involve in the functional regulation of salivary gland, however, its role in DM-impaired gland is unknown. Therefore, this study aimed to investigate the expression profiles and functional ne...

journal_title：Life sciences

authors： Huang Y,Liu HM,Wu LL,Yu GY,Xiang RL

更新日期：2021-01-04 00:00:00

abstract：:We studied the different effects of three kinds of somatostatin (somatostatin 1-14, somatostatin 15-28, somatostatin 1-28) on the aggregation of rabbit's platelets. It was clarified that somatostatin 15-28 had inhibitory effects on rabbit's platelet aggregation stronger than somatostatin 1-14 did, and that somatostati...

journal_title：Life sciences

authors： Fuse I,Ito S,Takagi A,Shibata A

更新日期：1985-05-27 00:00:00

abstract：AIMS:The protein kinase C (PKC) family of enzymes has been implicated in cellular proliferation, differentiation, and apoptosis. However, the distribution of specific PKC isoforms with varying functions in normal and malignant human tissues remains to be determined. The objective of this study was to investigate the ex...

journal_title：Life sciences

authors： Ali S,Al-Sukhun S,El-Rayes BF,Sarkar FH,Heilbrun LK,Philip PA

更新日期：2009-05-22 00:00:00

abstract：:Nociceptin/orphanin FQ (=N/OFQ), the endogenous ligand of ORL1 receptor (=NOP), has been reported to induce, in rodents, after intracerebroventricular (i.c.v.) administration, anti-stress and anxiolytic effects. We have observed that the handling of mice followed by an i.c.v. injection of saline, induced a marked incr...

journal_title：Life sciences

authors： Le Cudennec C,Naudin B,Do Rego JC,Costentin J

更新日期：2002-11-29 00:00:00

abstract：:The binding of the D2-like agonists, (+)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin (7-OH-DPAT) and [3H]pramipexole (2-amino-4,5,6-tetrahydro-6-propylaminobenzthiazole; MIRAPEX) were determined in membranes from adult male Sprague-Dawley and Fischer-344 rats. Saturation analysis, which optimized binding to D3 recep...

journal_title：Life sciences

authors： Wallace DR,Owens J,Booze RM

更新日期：1998-01-01 00:00:00

abstract：:In order to clarify the role played by interleukin-2 (IL-2) in the regulation of fibroblast function, we investigated the effect of rat IL-2 and human recombinant IL-2 on 3T3 fibroblast proliferation and collagen synthesis. Fibroblasts were incubated with various concentrations of IL-2 for different periods of time. I...

journal_title：Life sciences

authors： Rubinchik E,Levi-Schaffer F

更新日期：1996-01-01 00:00:00

abstract：AIMS:The type 2 muscarinic receptor (M2R) differs from the other G-protein-coupled muscarinic receptor (type 4, or M4R) in tissue distribution and physiologic effects. We studied the impact of these receptors on sleep and arousal by using M2R and M4R knock-out (KO) mice. MAIN METHODS:M2R and M4R KO and genetically int...

journal_title：Life sciences

authors： Turner J,Hughes LF,Toth LA

更新日期：2010-01-30 00:00:00

abstract：:Cd2+ (0.4 mg/kg) administration to growing rats (45 +/- 5 g) intraperitoneally, daily for 30 days was found to decrease the activity of superoxide dismutase (SOD) in all the brain regions, except hippocampus. The concentrations of lipid peroxides were significantly elevated in the cerebellum, cerebral cortex, corpus s...

journal_title：Life sciences

authors： Shukla GS,Hussain T,Chandra SV

更新日期：1987-11-09 00:00:00

abstract：:Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potent...

journal_title：Life sciences

authors： Jain A,Rani V

更新日期：2018-07-15 00:00:00

abstract：:In our previous paper (Biochem. Biophys. Res. Commun. 141, 20-26 (1986) we reported the isolation of a 34000-dalton protein (p34K) which binds to calmodulin and F-actin from chicken gizzard smooth muscle. We examined the distribution of the immunoreactive component of gizzard p34K in bovine tissues by immunoblot analy...

journal_title：Life sciences

authors： Takahashi K,Hiwada K,Kokubu T

更新日期：1987-07-20 00:00:00

abstract：:Trichosanthin (TCS) is a type 1 ribosome-inactivating protein (RIP) effective against HIV-1 and HSV-1 replication. The mechanism of its antiviral activity is not clear. Many believe that it is related to ribosome inactivation. Some RIPs and viral infection affect the phosphorylation of MAPK and Bcl-2 and these protein...

journal_title：Life sciences

authors： Huang H,Chan H,Wang YY,Ouyang DY,Zheng YT,Tam SC

更新日期：2006-08-22 00:00:00

abstract：:The present study was undertaken to evaluate the cardioprotective potential of Curcuma longa (Turmeric) in the ischemia-reperfusion (I/R) model of myocardial infarction (MI). Wistar rats were divided into three groups and received saline orally (sham, control I/R group) and Curcuma longa 100 mg/kg (CL-100 treated grou...

journal_title：Life sciences

authors： Mohanty I,Singh Arya D,Dinda A,Joshi S,Talwar KK,Gupta SK

更新日期：2004-08-20 00:00:00

abstract：:The effect of thapsigargin, a specific inhibitor of intracellular Ca(2+)-ATPases, on endothelium-dependent relaxation was studied in the guinea pig thoracic aorta. Thapsigargin (1 nM-1 microM) produced a concentration-dependent relaxation of aortic strips precontracted by phenylephrine (0.1 microM) in the presence and...

journal_title：Life sciences

authors： Matsuyama S,Shuntoh H,Katayama S,Tanaka C

更新日期：1993-01-01 00:00:00

abstract：:Tobacco smoke exposure has been shown to inhibit brain and platelet MAO B in animals and in humans. Though the mechanism(s) responsible for MAO B inhibition are not known, studies in rodents have shown that nicotine administration does not inhibit brain MAO B. In this study we investigated whether brain MAO B is also ...

journal_title：Life sciences

authors： Fowler JS,Volkow ND,Logan J,Pappas N,King P,MacGregor R,Shea C,Garza V,Gatley SJ

更新日期：1998-01-01 00:00:00

abstract：AIMS:Dysfunction of the Hippo-Yes-Associated Protein (YAP) signaling pathway is known to be associated with hepatocellular carcinoma (HCC). Evodiamine (Evo), a plant-derived bioactive alkaloid, exerts inhibitory effects on cancer. However, the precise influence of Evo on HCC and its potential effects on Hippo-YAP signa...

journal_title：Life sciences

authors： Zhao S,Xu K,Jiang R,Li DY,Guo XX,Zhou P,Tang JF,Li LS,Zeng D,Hu L,Ran JH,Li J,Chen DL

更新日期：2020-06-15 00:00:00

abstract：:The application of acetic acid to the hind leg of a frog will induce a spinally mediated wiping reflex only if the acetic acid concentration is above a certain threshold. By using this reflex as the basis of a test for nociception, we show that morphine sulfate is a potent analgesic in the frog when injected into the ...

journal_title：Life sciences

authors： Stevens CW,Pezalla PD

更新日期：1983-11-21 00:00:00

abstract：:The participation of the medullary structures in the total respiratory effect of opiates was studied by restricting the access of the delta-agonist D-ala2-D-leu5-enkephalin and the mu-agonist D-ala2-Me-Phe4-Met (O) ol5-enkephalin, to the ventral medullary surface, and by comparing their responses with those induced af...

journal_title：Life sciences

authors： Flórez J,Hurlé MA,Mediavilla A

更新日期：1982-11-15 00:00:00

abstract：:In order to determine whether CCl4, CBrCl3, CBr4 or CHCl3 undergo oxidative metabolism to electrophilic halogens by liver microsomes, they were incubated with liver microsomes from phenobarbital pretreated rats in the presence of NADPH and 2,6-dimethylphenol. The analysis of the reaction mixtures by capillary gas chro...

journal_title：Life sciences

authors： Mico BA,Branchflower RV,Pohl LR,Pudzianowski AT,Loew GH

更新日期：1982-01-11 00:00:00

abstract：:Three cholecystokinin type B (CCKB) receptor antagonists were labelled with 11C and evaluated ex vivo in rat biodistribution studies. The CCKB antagonists were YF 476 and two other compounds of the basic 3-ureido-1,4-benzodiazepine class. Following tail-vein administration of [11C]-YF 476 exceedingly low levels of rad...

journal_title：Life sciences

authors： Wilson AA,Jin L,Garcia A,DaSilva JN,Houle S

更新日期：2001-02-02 00:00:00

abstract：:Bile duct ligation (BDL) in rats induces portal fibrosis. This process has been linked to changes in the oxidative state of the hepatic cells and in the production of nitric oxide. Our objective was to find possible temporal connections between hepatic redox state, NO synthesis and liver injury. In this work we have c...

journal_title：Life sciences

authors： Vázquez-Gil MJ,Mesonero MJ,Flores O,Criado M,Hidalgo F,Arévalo MA,Sánchez-Rodríguez A,Tuñón MJ,López-Novoa JM,Esteller A

更新日期：2004-06-25 00:00:00

abstract：:Previous studies demonstrated a direct action of interleukin-1 (IL-1) on release of hormones from rat anterior pituitary cells in monolayer culture. To rule out any possibility of a paracrine effect from the elevated hormones in the static monolayer system, and to examine further the dynamics of hormone release elicit...

journal_title：Life sciences

authors： Beach JE,Smallridge RC,Kinzer CA,Bernton EW,Holaday JW,Fein HG

更新日期：1989-01-01 00:00:00