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Complement inactivation by allergenic plant pollen extracts.

Abstract：

:Dialyzed aqueous extracts of plant pollen are widely used in the clinical practice of allergy for diagnostic and therapeutic purposes. The present investigation shows that such allergenic extracts are capable of consuming complement in every human serum, independent of the clinical condition. Complement is engaged by way of the first component C1, but without the participation of allergen-specific antibodies. The capacity of distinct pollen extracts to inactivate haemolytic complement was found to depend on the plant species, the most potent extracts being from the pollen of the weeds and trees. Analysis by UV-spectroscopy of the flavonoids remaining firmly bound to the proteins gives rise to the proposal that complement inactivation by allergenic and non-allergenic pollen extracts is due to polyphenolic (flavonoid) structures complexed with, or chemically conjugated to, the pollen proteins.

journal_name

Life Sci

journal_title

Life sciences

authors

Berrens L,de la Cuadra B,Gallego MT

doi

10.1016/s0024-3205(97)00101-x

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

1497-503

issue

17

eissn

0024-3205

issn

1879-0631

pii

S002432059700101X

journal_volume

60

pub_type

杂志文章

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