Tetrahydroaminoacridine affects the cholinergic function of blood-brain barrier.

abstract：AIMS:The aim of study is to investigate the effect of nifedipine on viral myocarditis in an animal model. MAIN METHODS:Four-week-old male DBA/2 mice were inoculated with 2 pfu of encephalomyocarditis virus (EMCV) and randomized to nifedipine (n=10) or control (n=10) group. The control group was fed by regular chow and...

journal_title：Life sciences

authors： Liu W,Shimada M,Xiao J,Hu D,Matsumori A

更新日期：2009-07-31 00:00:00

abstract：:This investigation examines the role of Angiotensin II in renal hemodynamic functions during acute unilateral ureteral obstruction (UUO) in a dog model. An electro magnetic flow probe was utilized to assess renal blood flow while the arteriovenous extraction technique of technetium 99m DTPA was utilized for the assess...

journal_title：Life sciences

authors： Katzberg RW,DiMarco PL,Morris TW,Harnish PP,Graves RF,Merguerian PA,Ventura JA,Proskin HM

更新日期：1988-01-01 00:00:00

abstract：:Metabolic flux through the purine salvage pathway appears to modulate superoxide secretion by elicited macrophages. Exogenous adenosine, the first substrate of this pathway, stimulates superoxide secretion, and Allopurinol, a specific inhibitor of xanthine oxidase, inhibits superoxide secretion. The effects of these a...

journal_title：Life sciences

authors： Tritsch GL,Niswander PW

更新日期：1983-03-21 00:00:00

abstract：:Extracts of Hypericum perforatum (St. John's wort) have antidepressant properties in depressed patients and exert antidepressant-like action in laboratory animals. The phloroglucinol derivative hyperforin has become a topic of interest, as this Hypericum component is a potent inhibitor of monoamines reuptake. The mole...

journal_title：Life sciences

authors： Roz N,Rehavi M

更新日期：2003-06-13 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), a major steroid secreted by the adrenal gland, is known to have antiproliferative effects but the mechanism is unclear. We recently reported that DHEA induces growth inhibition and apoptosis in BV-2 cells and these effects are inversely associated with glucose concentrations in the mediu...

journal_title：Life sciences

authors： Yang NC,Jeng KC,Ho WM,Hu ML

更新日期：2002-03-15 00:00:00

abstract：AIMS:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered to be one of the most promising candidates in research on treatments for cancer, including renal cell carcinoma (RCC). However, many cells are resistant to TRAIL-induced apoptosis which limits the potential application of TRAIL in ...

journal_title：Life sciences

authors： Ou YC,Li JR,Kuan YH,Raung SL,Wang CC,Hung YY,Pan PH,Lu HC,Chen CJ

更新日期：2014-04-01 00:00:00

abstract：:Intestinal mucosa, bone marrow hematopoietic cells and brain have limited capacity for the de novo synthesis of nucleosides (NSs) and nucleotides (NTs). Whereas the role of dietary NS and NT in the former two tissues is known, it is not known in the brain. Therefore we studied the effect of dietary NS and NT mixture o...

journal_title：Life sciences

authors： Chen TH,Huang HP,Matsumoto Y,Wu SH,Wang MF,Chung SY,Uezu K,Moriyama T,Uezu E,Korin T,Sato S,Yamamoto S

更新日期：1996-01-01 00:00:00

abstract：:Previous studies have indicated that one of the causes of alveolar bone destruction with periodontitis is lipopolysaccharide (LPS) from the cell wall of gram-negative bacteria in plaque, and that prostaglandin E(2) (PGE(2)) is one of the bone resorption factors that stimulate osteoclast formation through an intercellu...

journal_title：Life sciences

authors： Shoji M,Tanabe N,Mitsui N,Tanaka H,Suzuki N,Takeichi O,Sugaya A,Maeno M

更新日期：2006-03-20 00:00:00

abstract：:In the course of investigating the binding of imipramine to soluble cellular fractions from brain and leukocytes using equilibrium dialysis, an artifactual binding component was produced. On Scatchard and double-reciprocal plots of the data, the component appeared as a homogenous population of sites displaying a bindi...

journal_title：Life sciences

authors： Cullen EI,Medzihradsky F

更新日期：1983-07-11 00:00:00

abstract：:Uncoupling proteins (UCPs) are supposed to be involved in diet-induced thermogenesis. Their activities are usually elevated by feeding and reduced by fasting in normal animals. To investigate whether fasting affects the expression of UCPs mRNA in brown adipose tissue (BAT) of bilateral ventromedial hypothalamus (VMH)-...

journal_title：Life sciences

authors： Kageyama H,Osaka T,Kageyama A,Kawada T,Hirano T,Oka J,Miura M,Namba Y,Ricquier D,Shioda S,Inoue S

更新日期：2003-05-16 00:00:00

abstract：:Endothelin-1 (ET-1) is produced from its precursor, big endothelin-1 (BigET-1), by a putative endothelin-converting enzyme (ECE), but it is not known whether the enzyme is present in the brain. This study was conducted to examine the central hemodynamic effects of BigET-1 and to indirectly determine the presence of an...

journal_title：Life sciences

authors： Hashim MA,Tadepalli AS

更新日期：1991-01-01 00:00:00

abstract：:The adverse effects of prenatal nicotine and alcohol exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, substantial percentage of women (20-25%) of childbearing age currently smoke cigarettes and consume alcohol, and only a small percentage of these individu...

journal_title：Life sciences

authors： Bhattacharya D,Majrashi M,Ramesh S,Govindarajulu M,Bloemer J,Fujihashi A,Crump BR,Hightower H,Bhattacharya S,Moore T,Suppiramaniam V,Dhanasekaran M

更新日期：2018-02-01 00:00:00

abstract：:Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute liver injury mediated by reactive oxygen species (ROS) as normal metabolites in hepatocytes. In this study, the molecular process in this type of liver injury was analyzed from the aspect of liver function and regulatory factor...

journal_title：Life sciences

authors： Taniguchi M,Takeuchi T,Nakatsuka R,Watanabe T,Sato K

更新日期：2004-08-13 00:00:00

abstract：:This study examined the protective effect of phenobarbital on kainic acid-induced deficits in acquisition learning. A single kainic acid injection (9 mg/kg i.p.) was administered five days prior to testing using the Morris water maze test. Kainic acid produced deficits in the acquisition of spatial information observe...

journal_title：Life sciences

authors： Brown-Croyts LM,Caton PW,Radecki DT,McPherson SL

更新日期：2000-06-30 00:00:00

abstract：AIMS:Salivary gland dysfunction is a common complication of diabetes mellitus (DM). Long non-coding RNA (lncRNA) is evidenced to involve in the functional regulation of salivary gland, however, its role in DM-impaired gland is unknown. Therefore, this study aimed to investigate the expression profiles and functional ne...

journal_title：Life sciences

authors： Huang Y,Liu HM,Wu LL,Yu GY,Xiang RL

更新日期：2021-01-04 00:00:00

abstract：:In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress-induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, i.p.) or an equal volume of saline once a day for two days. Animals received no treatment on...

journal_title：Life sciences

authors： Bell RL,Soignier RD,Olson RD,Vaccarino AL

更新日期：1998-01-01 00:00:00

abstract：:The effect of diabetes mellitus on serum cholesterol and aortic microsomal prostanoid synthesis was studied in cholesterol fed male Lewis rats. Normal, diabetic and diabetic rats treated with pancreatic islets were divided into three diet subgroups, control diet, control +2% cholesterol for 8 weeks and control +2% cho...

journal_title：Life sciences

authors： Myers SI,Bartula L,Linzel M,Phan T,Jung PJ,Merrell RC

更新日期：1990-01-01 00:00:00

abstract：:Two-dimensional and line-scan analyses of the early phase Ca2+ transients in rat cardiomyocytes were performed with a rapid-scanning laser confocal microscope and fluo-3 to elucidate the mechanism of activation of Ca2+ release from the sarcoplasmic reticulum in atrial myocytes which lack a well developed T-tubular net...

journal_title：Life sciences

authors： Tanaka H,Masumiya H,Sekine T,Kase J,Kawanishi T,Hayakawa T,Miyata S,Sato Y,Nakamura R,Shigenobu K

更新日期：2001-12-28 00:00:00

abstract：:We determined by PCR the number of (A-C)n repeats in the 2. 1 kb upstream of the aldose reductase (AR2) gene in healthy control subjects and in patients with NIDDM in Japanese. Sixty-one patients were recruited based on the severity of retinopathy and subdivided into two groups with proliferative retinopathy and witho...

journal_title：Life sciences

authors： Ikegishi Y,Tawata M,Aida K,Onaya T

更新日期：1999-01-01 00:00:00

abstract：:Fish oil is rich in the long chain n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); typically these fatty acids constitute 20 to 25 g/100 g total fatty acids in fish oil. Feeding rodents diets rich in fish oil has been shown to decrease lymphocyte proliferation and natural ki...

journal_title：Life sciences

authors： Peterson LD,Thies F,Sanderson P,Newsholme EA,Calder PC

更新日期：1998-01-01 00:00:00

abstract：:NMDA receptors are glutamate-regulated ion channels of critical importance for many neurophysiological and neuropathological processes. Mg2+ blocks the NMDA receptor by binding to the channel pore with an apparent affinity that depends on the membrane potential. We have investigated the effect of NMDA and the required...

journal_title：Life sciences

authors： Liu Y,Hill RH,Arhem P,von Euler G

更新日期：2001-03-09 00:00:00

abstract：:The bone marrow is home to mesenchymal stem cells (MSCs) that are able to differentiate into many different cell types. The effect of hyperbaric oxygen (HBO) on MSCs is poorly understood. Placental growth factor (PlGF) is an attractive therapeutic agent for stimulating revascularization of ischemic tissue. HBO has bee...

journal_title：Life sciences

authors： Shyu KG,Hung HF,Wang BW,Chang H

更新日期：2008-07-04 00:00:00

abstract：AIMS:Lithium is a common mood stabilizer to treat bipolar disorder. It has a narrow window of therapeutic action and its mechanism of action and possible side effects are still not fully understood. Lithium is a potent inhibitor of glycogen synthase kinase 3β (GSK-3β). Previous studies indicated that lithium can induce...

journal_title：Life sciences

authors： Tsui MM,Tai WC,Wong WY,Hsiao WL

更新日期：2012-09-24 00:00:00

abstract：:The nonsteroidal anti-inflammatory drug zomepirac (ZP) is metabolised to a chemically reactive acyl glucuronide conjugate (ZAG) which can form covalent adducts with proteins. In vivo, such adducts could initiate immune or toxic responses. In rats given ZP, the major band detected in liver homogenates by immunoblotting...

journal_title：Life sciences

authors： Wang M,Gorrell MD,McGaughan GW,Dickinson RG

更新日期：2001-01-05 00:00:00

abstract：:The beta-endorphin, met5-enkephalin-arg6-phe7 (MEAP) and met5-enkephalin (ME) changes related to age and diurnal rhythms were studied in various regions of rat brain and in the pituitary by specific radioimmunoassays. The contents of MEAP, met5-enkephalin and beta-endorphin were higher in the pituitary of old rats (18...

journal_title：Life sciences

authors： Tang F,Tang J,Chou J,Costa E

更新日期：1984-08-27 00:00:00

abstract：AIM:Preparation of pegylated gold nanorods (PEG-AuNRs) that are capable of converting near infrared (NIR) light into heat. Evaluation of cancer therapeutic efficacy and long-term toxicity of the proposed photothermal therapy in comparison with other conventional modalities. MATERIALS AND METHODS:Prepared PEG-AuNRs wer...

journal_title：Life sciences

authors： Monem AS,Sayed FA,Rageh MM,Mohamed N

更新日期：2020-09-15 00:00:00

abstract：:The present study was designed to investigate the effects of chronic administration of the alcoholic extract of Terminalia arjuna (TAAE) bark on isoproterenol induced myocardial injury. The TAAE was administered orally to Wistar albino rats (150-200 g) in three different doses, by gastric gavage [3.4 mg/kg: (T1), 6.75...

journal_title：Life sciences

authors： Karthikeyan K,Bai BR,Gauthaman K,Sathish KS,Devaraj SN

更新日期：2003-10-10 00:00:00

abstract：:Phosphoesterase complex (Pho), a major active component of barley malt, has been demonstrated to be clinically effective in relieving alcoholic fatty liver disease (AFLD), and several lines of evidence have suggested that microbial dysbiosis, caused by chronic alcohol overconsumption, plays a key role in the progressi...

journal_title：Life sciences

authors： Ma D,Hu J,Xu W,Wang Y,Wang J,Li L,Wang S,Zhou H,Li Y,Liu L

更新日期：2020-12-01 00:00:00

abstract：:The metabolic capability of hepatocytes prepared by the perfusion method (P cells) and the tissue slice method (S cells) has been compared using standardised procedures. Yields of P cells were four times greater than for S cells. Trypan blue exclusion viability and oxygen utilization were similar although the viabilit...

journal_title：Life sciences

authors： Sturdee AP,Beirne JM,Sörman AE,Orton TC,Crisp DM

更新日期：1983-03-28 00:00:00

abstract：:Activin A is a member of the transforming growth factor-beta superfamily that exerts its diverse biological effects through bindings to activin specific transmembrane serine/threonine kinase receptors. The fibroblast-mediated contraction of a collagen gel is thought to be a model of part of the wound-repair response a...

journal_title：Life sciences

authors： Ohga E,Matsuse T,Teramoto S,Ouchi Y

更新日期：2000-03-01 00:00:00