Epinephrine sulfation in the forearm: arteriovenous differences in free and conjugated catecholamines.

abstract：:Uric acid values in serum have been analyzed as one of the markers to predict cellular damage due to ischemia reperfusion injury in the field of organ transplantation. The present study was conducted to confirm that uric acid values in serum could be an efficient marker of ischemic injury of liver parenchyma following...

journal_title：Life sciences

authors： Kogure K,Ishizaki M,Nemoto M,Kuwano H,Tatemoto K,Maruyama Y,Ikarashi Y,Makuuchi M

更新日期：1999-01-01 00:00:00

abstract：:miRNAs are a group of non-coding RNAs that have regulatory functions in post-transcriptional gene expression. These molecules play a fundamental role in cellular processes, for instance cell proliferation, apoptosis, migration, and invasion. Scientific investigations have previously established that miRNAs can either ...

journal_title：Life sciences

authors： Khalili N,Nouri-Vaskeh M,Hasanpour Segherlou Z,Baghbanzadeh A,Halimi M,Rezaee H,Baradaran B

更新日期：2020-09-01 00:00:00

abstract：:Peptide Histidine Isoleucine (PHI) is generally considered a low affinity agonist for Vasoactive Intestinal Peptide (VIP) receptors. In this study, we investigated the presence and characteristics of [125I]PHI binding sites on rat liver membranes. Detergents at nonsolubilizing concentrations (1 mM CHAPS or 0.01% Tween...

journal_title：Life sciences

authors： Paul S,Chou J,Kubota E

更新日期：1987-11-23 00:00:00

abstract：AIM:Myocardial infarction (MI), an important cause of morbidity and mortality, can be followed by left ventricular dysfunction and cardiomyocyte loss. Cardiac repair mechanisms may subsequently improve left ventricular function. Exercise training has been suggested to have cardioprotective effects against MI damage, bu...

journal_title：Life sciences

authors： Naderi N,Hemmatinafar M,Gaeini AA,Bahramian A,Ghardashi-Afousi A,Kordi MR,Darbandi-Azar A,Karimzade F,Mohebbi H,Barati M

更新日期：2019-03-15 00:00:00

abstract：:Vascular endothelial cells have been found to produce a relaxant mediator, identified as nitric oxide (NO) and implicated in numerous physiological functions. Subsequently, there has been an intensive search for accurate and specific detection methods to measure biological NO production. In the present study, we compa...

journal_title：Life sciences

authors： Privat C,Lantoine F,Bedioui F,Millanvoye van Brussel E,Devynck J,Devynck MA

更新日期：1997-01-01 00:00:00

abstract：:Human uridinediphosphate-glucuronosyltransferase 1A1 (UGT1A1) was expressed in Salmonella typhimurium TA1535 cells by transfection of the cells with plasmids carrying the UGT1A1 cDNA. UGT1A1 cDNA was isolated by a polymerase chain reaction from human liver total RNA and was inserted into the pSE420 plasmid, linked to ...

journal_title：Life sciences

authors： Fujita K,Mogami A,Hayashi A,Kamataki T

更新日期：2000-04-07 00:00:00

abstract：:Low pH medium has been shown to activate the 'efferent' function of capsaicin-sensitive primary sensory neurons. Calcitonin gene-related peptide (CGRP) is released from capsaicin-sensitive afferents of guinea-pig superior sagittal and transverse sinuses (SSTS), by capsaicin or bradykinin. Here, we report that low pH m...

journal_title：Life sciences

authors： Fanciullacci M,Tramontana M,Del Bianco E,Alessandri M,Geppetti P

更新日期：1991-01-01 00:00:00

abstract：:Alpha adrenergic agonists and antagonists as clonidine, guanfacine, yohimbine, phenylephrine and prazosin inhibited the [3H]-QNB binding to rat brain cortex muscarinic acetylcholine receptor (mAChR, M-1 subtype), heart (M-2 subtype) and parotid gland homogenate (M-3 subtype) in a dose-dependent competitive fashion. Ki...

journal_title：Life sciences

authors： Simon G,Filep J,Zelles T

更新日期：1990-01-01 00:00:00

abstract：:Inhaled antimuscarinics, often called anticholinergics in clinical medicine, are established as first line bronchodilators in COPD. Tiotropium has been developed as a new generation antimuscarinic following ipratropium. Tiotropium is a specific, highly potent antimuscarinic, demonstrating very slow dissociation from m...

journal_title：Life sciences

authors： Disse B,Speck GA,Rominger KL,Witek TJ Jr,Hammer R

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:This study investigated the role of long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) in kidney injury induced by urine-derived sepsis (US). MATERIALS AND METHODS:An Escherichia coli suspension was injected into the distal ureter of adult male Sprague Dawley rats to establish a US model. Lipo...

journal_title：Life sciences

authors： Shen J,Zhang J,Jiang X,Wang H,Pan G

更新日期：2018-10-01 00:00:00

abstract：:Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects ...

journal_title：Life sciences

authors： Rahmani S,Pour Khalili N,Khan F,Hassani S,Ghafour-Boroujerdi E,Abdollahi M

更新日期：2018-12-01 00:00:00

abstract：:We have previously shown that matrix metalloproteinases (MMPs) play a role in osteoclastic bone resorption by facilitating migration of osteoclastic cells toward bone surface through matrices. Of MMPs identified so far, MMP-9 is likely the most important proteinase for the action, since osteoclasts express this enzyme...

journal_title：Life sciences

authors： Ishibashi O,Niwa S,Kadoyama K,Inui T

更新日期：2006-09-20 00:00:00

abstract：:Endothelin-1 (ET-1) is produced from its precursor, big endothelin-1 (BigET-1), by a putative endothelin-converting enzyme (ECE), but it is not known whether the enzyme is present in the brain. This study was conducted to examine the central hemodynamic effects of BigET-1 and to indirectly determine the presence of an...

journal_title：Life sciences

authors： Hashim MA,Tadepalli AS

更新日期：1991-01-01 00:00:00

abstract：:Bacterial endotoxin or lipopolysaccharide (LPS) can trigger inflammatory responses and cause damage in organs such as liver and lungs when it is introduced into mammals, but the exact molecular events that mediate these responses have remained obscure. In this study, by using 2D gel electrophoresis and cDNA microarray...

journal_title：Life sciences

authors： Xie W,Shao N,Ma X,Ling B,Wei Y,Ding Q,Yang G,Liu N,Wang H,Chen K

更新日期：2006-10-04 00:00:00

abstract：:Concanavalin A enhanced the rat rectal absorption of phenol red and cefoxitin at pH 7.4 and the uptake of cefoxitin into brush border membrane vesicles prepared from rat rectal membrane. The enhancing action of concanavalin A demonstrated a sodium ion dependency and was inhibited by the presence of 4,4'-diisothiocyano...

journal_title：Life sciences

authors： Nishihata T,Higuchi T

更新日期：1984-01-30 00:00:00

abstract：AIMS:TsTX-I scorpion toxin, also known as γ-toxin, is a β-toxin which binds to site 4 of the sodium channel, shifting its activation potential. There are few studies about its pharmacological action in the central nervous system. The objective of this work was to determine the electroencephalographic, behavioral and hi...

journal_title：Life sciences

authors： Teixeira VF,Conceição IM,Lebrun I,Nencioni AL,Coronado Dorce VA

更新日期：2010-10-09 00:00:00

abstract：:In 6-[18F]fluoro-L-dopa (Fdopa)/positron emission tomography (PET) studies, carbidopa pretreatment increases the Fdopa bioavailability to the brain and enhances the intensity of striatal PET images. Different PET research teams have used various carbidopa doses and routes of administration in non-human primate studies...

journal_title：Life sciences

authors： Chan GL,Doudet DJ,Dobko T,Hewitt KA,Schofield P,Pate BD,Ruth TJ

更新日期：1995-01-01 00:00:00

abstract：:The ontogenetic development of [3H]-spiroperidol binding sites was measured in the optic tectum, cerebellum, forebrain base, and forebrain roof of 1-, 4-, and 16-day-old chicks. In the chick optic tectum and cerebellum both the density and the total number of [3H]-spiroperidol binding sites increased from 4- to 16-day...

journal_title：Life sciences

authors： McDougall SA,Neisewander JL,Bardo MT,Zolman JF

更新日期：1989-01-01 00:00:00

abstract：:Ethanol-induced emesis were investigated using Suncus murinus and the emetogenic mechanisms of ethanol were compared with those of cisplatin. Intraperitoneal injection of ethanol caused dose-dependent emesis with ED50 value of 22.3% (v/v) when injection volume was adjusted to 4 ml/kg. Intraperitoneal and subcutaneous ...

journal_title：Life sciences

authors： Chen Y,Saito H,Matsuki N

更新日期：1997-01-01 00:00:00

abstract：AIMS:The heterodimerization of angiotensin II receptors (AT1R and AT2R) with adiponectin receptor AdipoR1 and AdipoR2 may instigate high glucose (HG)-induced renal tubulointerstitial injury. This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism. MAIN METHODS:Diabetes w...

journal_title：Life sciences

authors： Zha D,Yao T,Bao L,Gao P,Wu X

更新日期：2019-03-15 00:00:00

abstract：:The expression of the corticotropin-releasing hormone (CRH) gene and the arginine vasopressin (AVP) gene in the hypothalamus examined in bilateral nephrectomized rats by in situ hybridization histochemistry. The expression of the CRH gene was significantly increased in the parvocellular part of the paraventricular nuc...

journal_title：Life sciences

authors： Nomura M,Serino R,Yamamoto Y,Ozaki Y,Saito J,Matsumoto T,Yamashita H,Ueta Y

更新日期：2002-12-20 00:00:00

abstract：:The mechanism of the antithrombotic effects of heparin and the synthetic antithrombin agent argatroban was evaluated in a dog model. Thrombus formation following balloon injury was evaluated by angioscopy in the right iliac arteries of 20 dogs to serve as a control. After the evaluation of the growth of thrombus on th...

journal_title：Life sciences

authors： Tomaru T,Kawano HA,Tsujiuchi Y,Suzuki J,Nakajima T,Uchida Y

更新日期：2005-10-07 00:00:00

abstract：:Identifying factors that modulate cocaine self-administration is fundamental to the development of effective strategies to treat and prevent cocaine abuse. In the present study, the influence of an alternative reinforcer on the probability of cocaine use was examined in four adult humans under controlled laboratory co...

journal_title：Life sciences

authors： Higgins ST,Bickel WK,Hughes JR

更新日期：1994-01-01 00:00:00

abstract：AIMS:TRAF6 is an intracellular signal adapter molecule plays a significant role in tumor development. However, the specific mechanism causes and promotes of colorectal cancer keep largely unknown. Therefore, we sought to investigate the roles and the molecular mechanisms of TRAF6 in regulation colorectal cancer. MATER...

journal_title：Life sciences

authors： Zhu G,Cheng Z,Huang Y,Zheng W,Yang S,Lin C,Ye J

更新日期：2019-10-15 00:00:00

abstract：AIMS:Evidence suggests that hypobaric hypoxia (HH) exposure causes biochemical and molecular level perturbations in brain resulting in associated cognitive dysfunction. However, the possible effect of HH on amygdala and the associated limbic regions based functions remains elusive. Regulated fear expression is essentia...

journal_title：Life sciences

authors： Kumari P,Roy K,Wadhwa M,Chauhan G,Alam S,Kishore K,Ray K,Panjwani U

更新日期：2020-08-01 00:00:00

abstract：:The purpose of the present study was to investigate whether Lewis (LEW) and spontaneously hypertensive rats (SHR), characterized in numerous behavioral tests as strains with high-anxiety and low-anxiety, respectively, could differ in their sensitivity to the effects of ethanol in the elevated plus maze (EPM) and the o...

journal_title：Life sciences

authors： Da Silva GE,Vendruscolo LF,Takahashi RN

更新日期：2005-06-24 00:00:00

abstract：:5-Bromo-2'-deoxyuridine (BrdU) has been recently found to enhance adrenal glucocorticoid secretion in rats. Since BrdU-labeling is today the most employed technique for assessing cell proliferation, we have investigated whether this side-effect of BrdU may influence mitotic activity (as evaluated by metaphase-arrested...

journal_title：Life sciences

authors： Malendowicz LK,Nussdorfer GG,Trejer M

更新日期：1997-01-01 00:00:00

abstract：AIMS:We explored the effect of aerobic exercise on renal sinus adipose (RSA) accumulation and RSA accumulation-related renal injury in obese mice. MAIN METHODS:C57BL/6J male mice (n = 30) were evenly divided into three groups: control group (CON, n = 10), obese group (OB, n = 10; given high-fat diet) and obese + aerob...

journal_title：Life sciences

authors： Wang SS,Gu Q,Liu N,Li J,Liu X

更新日期：2021-01-23 00:00:00

abstract：:Superoxide dismutase (SOD) levels, thought to be the first cellular defence against free radicals, were studied in the nonobese diabetesprone (NOD-p) mouse, an animal model of type 1 diabetes in which about 100% of females and 20% of males become diabetic. Nonobese diabetes nonprone (NON-p) mice were used as controls....

journal_title：Life sciences

authors： Papaccio G,Frascatore S,Pisanti FA,Latronico MV,Linn T

更新日期：1995-01-01 00:00:00

abstract：:Protein binding determination in post heparin plasma samples is complicated by the continued post heparin lipase activity, in vitro, during the binding analysis. The decomposition of lipoproteins and accumulation of nonesterified fatty acids (NEFA) results in artifically elevated free fractions of many drugs. This art...

journal_title：Life sciences

authors： Pearce GA,Brown KF

更新日期：1983-10-10 00:00:00