Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice.

abstract：:Retinoic acids and their cognate nuclear receptors exert a substantial regulatory role in cell growth and development as well as in the neuroendocrine system. These effects are primarily mediated by all-trans retinoic acid receptors (RARs), members of the steroid/thyroid hormone receptor superfamily of ligand inducibl...

journal_title：Life sciences

authors： Brtko J,Knopp J,Kvetnanský R

更新日期：2000-03-24 00:00:00

abstract：:Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can trigger fre...

journal_title：Life sciences

authors： Nobre MJ,Borelli KG,Brandão ML

更新日期：2002-11-08 00:00:00

abstract：OBJECTIVE:To investigate the expression and time-dependent manner of bradykinin (BK) as well as its receptors (Bradykinin receptors 1 and 2, B1R and B2R) in spinal cord ischemia-reperfusion injury (SCII) in rat model. METHODS:Sprague-Dawley (SD) rats were subjected to 1 h of infra-renal abdominal aorta occlusion and r...

journal_title：Life sciences

authors： Ma Z,Dong Q,Lyu B,Wang J,Quan Y,Gong S

更新日期：2019-02-01 00:00:00

abstract：:Ethanol-induced emesis were investigated using Suncus murinus and the emetogenic mechanisms of ethanol were compared with those of cisplatin. Intraperitoneal injection of ethanol caused dose-dependent emesis with ED50 value of 22.3% (v/v) when injection volume was adjusted to 4 ml/kg. Intraperitoneal and subcutaneous ...

journal_title：Life sciences

authors： Chen Y,Saito H,Matsuki N

更新日期：1997-01-01 00:00:00

abstract：:We have investigated the possible involvement of arachidonic acid metabolites in dopamine-induced inhibition of adrenocortical steroidogenesis. Administration of dopamine (5 x 10(-5) M) for 20 min to perifused frog adrenal slices caused a marked reduction of the release of both prostaglandin E2 (PGE2) and 6-keto-PGF1 ...

journal_title：Life sciences

authors： Morra M,Leboulenger F,Homo-Delarche F,Netchitalo P,Vaudry H

更新日期：1989-01-01 00:00:00

abstract：AIMS:Aging and drug-induced side effects may contribute to deteriorate mitochondrial bioenergetics in many tissues, including kidney and liver. One possibility is that the combination of both aging and drug toxicity accelerates the process of mitochondrial degradation, leading to progressive bioenergetic disruption. We...

journal_title：Life sciences

authors： Rocha-Rodrigues S,Santos-Alves E,Coxito PM,Marques-Aleixo I,Passos E,Guimarães JT,Martins MJ,Oliveira PJ,Magalhães J,Ascensão A

更新日期：2013-09-03 00:00:00

abstract：:The accumulation of inositol monophosphate (IP1) was measured after stimulation of 5-hydroxytryptamine2 (5-HT2) receptors on platelets from alcoholics and healthy controls. In controls, 5-HT induced a dose-dependent response with an EC50 = 2 x 10(-6) M and a maximal response at 10(-5) M. Ritanserin, a selective 5-HT2 ...

journal_title：Life sciences

authors： Simonsson P,Alling C

更新日期：1988-01-01 00:00:00

abstract：:Lewis rats were trained to self-stimulate the medial forebrain bundle (MFB) using a rate-frequency paradigm. They were then tested for the effects of the cannabinoid receptor agonist CP 55,940, the selective cannabinoid receptor antagonist SR 141716 and the dopamine D1 receptor antagonist SCH 23390. CP 55,940 (0, 10, ...

journal_title：Life sciences

authors： Arnold JC,Hunt GE,McGregor IS

更新日期：2001-11-21 00:00:00

abstract：:Morphine and the enkephalin-like peptide FK 33-824 given i.p. to rats potently inhibit gastrointestinal transit of a charcoal test meal, the doses inhibiting transit by 50% being respectively about 10 and 1 microgram/kg. These intestinal effects are opiate-specific, locally elicited and presumably involve the same act...

journal_title：Life sciences

authors： Manara L,Bianchi G,Fiocchi R,Notarnicola A,Peracchia F,Tavani A

更新日期：1982-09-20 00:00:00

abstract：AIMS:JM-1232(-) ((-)-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-phenyl-3,5,6,7-tetrahydrocyclopenta[f] isoindole-1(2H)-one) is a novel isoindoline compound that acts on benzodiazepine receptors. Clinical trials are being conducted to assess its potential clinical use as an intravenous anesthetic or sedative agent. In ...

journal_title：Life sciences

authors： Kato R,Watanabe R,Miki H,Ijiri Y,Hayashi T,Tanaka K

更新日期：2009-11-18 00:00:00

abstract：:Iron imbalance has been implicated in oxidative injury associated with many brain diseases. The present study investigated the importance of iron location in hydroxyl radical (.OH) generation and the link between .OH production evaluated by the salicylate method and lipid peroxidation monitored by thiobarbituric acid-...

journal_title：Life sciences

authors： Demougeot C,Marie C,Beley A

更新日期：2000-06-16 00:00:00

abstract：:We have confirmed that hypoxia elicits a substantial rise in blood choline levels in young adult rats. An intravenous infusion of tracer quantities of [2H4]-Ch, serial measurements of blood [2H0]-Ch and [2H4]-Ch, and a simple pharmacokinetic model were used to assess the bidirectional flux of choline between the centr...

journal_title：Life sciences

authors： Jenden DJ,Scremin OU,Roch M,Li G

更新日期：1996-01-01 00:00:00

abstract：AIMS:Activation of the renin-angiotensin system (RAS), renal oxidative stress and inflammation are constantly present in experimental hypertension. Nitric oxide (NO) inhibition with N(w)-nitro-L-arginine methyl ester (L-NAME) has previously been reported to produce hypertension, increased expression of Angiotensin II (...

journal_title：Life sciences

authors： Rincón J,Correia D,Arcaya JL,Finol E,Fernández A,Pérez M,Yaguas K,Talavera E,Chávez M,Summer R,Romero F

更新日期：2015-03-01 00:00:00

abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...

journal_title：Life sciences

authors： Asai M,Kawashima D,Katagiri K,Takeuchi R,Tohnai G,Ohtsuka K

更新日期：2011-02-14 00:00:00

abstract：AIMS:Steroid hormones and steroid receptors (SRs) play a crucial role in spermatogenesis. Steroid receptor coregulators are the major determinants of SR functioning, and any alteration in their expression is known to be associated with impaired spermatogenesis. Since Bisphenol A (BPA) exposure leads to an impairment of...

journal_title：Life sciences

authors： Salian S,Doshi T,Vanage G

更新日期：2009-07-03 00:00:00

abstract：:Earlier studies from the authors' laboratory showed that malnourishment induces alterations in the cardiovascular homeostasis increasing the basal mean arterial pressure and heart rate. In this study, the authors evaluated whether the sympathetic and parasympathetic efferent activities contribute to changes in the car...

journal_title：Life sciences

authors： Loss Ide O,Fernandes LG,Martins CD,Cardoso LM,Silva ME,Dias-da-Silva VJ,Moraes MF,Chianca DA Jr

更新日期：2007-08-23 00:00:00

abstract：:Site-directed mutagenesis has been used to evaluate the roles of the key aspartate and arginine residues in transmembrane domain three of the muscarinic receptors. The results suggest that the formation of an ionic bond between the Asp carboxylate group and the onium headgroup is essential to anchor acetylcholine in i...

journal_title：Life sciences

authors： Hulme EC,Curtis CA,Page KM,Jones PG

更新日期：1995-01-01 00:00:00

abstract：:T cell receptor (TCR/CD3) induced fluctuations in intracellular free ionizied calcium, [Ca2+]i, was analysed in the human T leukemia cell clone, Jurkat, cultured in the presence of the opioid methionine enkephalinamide (Met-Enk) in titrated concentrations (10[-7] to 10[-15] M) or saline (PBS). In the majority of indiv...

journal_title：Life sciences

authors： Sørensen AN,Claësson MH

更新日期：1998-01-01 00:00:00

abstract：:The kinetic parameters of serotonin (5-HT) uptake and imipramine binding of the synaptosomes and blood platelets of male Fawn-hooded rats, which have a 5-HT storage abnormality, and normal Sprague-Dawley rats were compared. The Vmax for 5-HT uptake of synaptosomes from Fawn-hooded rats was significantly greater than t...

journal_title：Life sciences

authors： Arora RC,Tong C,Jackman HL,Stoff D,Meltzer HY

更新日期：1983-08-01 00:00:00

abstract：:Preconditioning (PC) is a potential approach to myocardial protection. We hypothesize that brief ischemia or adenosine given prior to an extended period of warm ischemia may prevent myocardial stunning by altering myocardial metabolism. Using a global ischemia model, 19 dogs were subjected to no PC(control), two episo...

journal_title：Life sciences

authors： Phillips AB,Ko W

更新日期：2007-10-13 00:00:00

abstract：:Effects of lithium (Li) deficiency and/or immobilization stress on the thymus weight and differential blood count of rats were studied. The thymus weight of the rats fed a low Li diet were lighter than those of rats fed a Li supplemented diet, whether the rats were exposed to stress or not. Of the rats not exposed to ...

journal_title：Life sciences

authors： Ono T,Iijima M,Shinoda S,Wada O

更新日期：1997-01-01 00:00:00

abstract：AIMS:Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study aimed to investigate the effects of pretreatment of vitamin D3 (100, 1000, and 10,000 IU/kg) against lipopolysacchar...

journal_title：Life sciences

authors： Mokhtari-Zaer A,Hosseini M,Salmani H,Arab Z,Zareian P

更新日期：2020-07-15 00:00:00

abstract：:Using Sokoloff's 2-deoxyglucose (2-DG) autoradiographic technique, the psychotomimetic drug, phencyclidine (PCP, "angel dust") dramatically increased metabolism in diencephalic and telencephalic brain regions known to be rich in high affinity PCP receptors. These effects were greatest in the limbic circuit described i...

journal_title：Life sciences

authors： Piercey MF,Ray CA

更新日期：1988-01-01 00:00:00

abstract：:Novel magnetic resonance imaging sequences have and still continue to play an increasing role in neuroimaging and neuroscience. Among these techniques, diffusion-weighted imaging (DWI) has revolutionized the diagnosis and management of diseases such as stroke, neoplastic disease and inflammation. However, the effects ...

journal_title：Life sciences

authors： Rau PR,Sellner J,Heiland S,Plaschke K,Schellinger PD,Meyding-Lamadé UK,Lamadé WR

更新日期：2006-02-09 00:00:00

abstract：:Previous in vitro evidence suggests that adrenaline causes K influx in skeletal muscle by stimulating a ouabain sensitive Na/K ATPase membrane pump. However in rabbits, adrenaline induced hypokalaemia was not significantly altered by pretreatment with digoxin (50 micrograms/kg). Rats were infused with adrenaline or sa...

journal_title：Life sciences

authors： Struthers AD,Davies DL,Harland D,Price JS,Brown RA,Quigley C,Brown MJ

更新日期：1987-01-05 00:00:00

abstract：AIMS:7-Ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxidized low-density lipoprotein (oxLDL), has been reported to be a crucial ligand of beta2-glycoprotein I (β(2)-GPI), and plays a potential role in the development of atherosclerosis (AS), however, the role of the sole oxLig-1 in the development of...

journal_title：Life sciences

authors： Huang Z,Li W,Wang R,Zhang F,Chi Y,Wang D,Liu Z,Zhang Y,Matsuura E,Liu Q

更新日期：2010-11-20 00:00:00

abstract：:Synthetic atriopeptin II (APII) was infused directly into the right renal artery of intact conscious SHR at rates of 0.25-1 microgram/kg/min, while simultaneously measuring blood pressure (MAP) and selected regional blood flows. The latter were measured using chronically implanted miniaturized Doppler flowprobes that ...

journal_title：Life sciences

authors： Smits JF,van Essen H,Struyker-Boudier HA,Lappe RW

更新日期：1986-01-06 00:00:00

abstract：:Several recent reports indicate that patients with Huntington's Disease (HD) may manifest membrane abnormalities in a wide variety of cells including peripheral blood lymphocytes. In this study, flow cytometry is used in conjunction with the fluorescent membrane probe, 8-anilino-1-naphthalene sulfonate (ANS), to exami...

journal_title：Life sciences

authors： Gollin SM,Leary JF,Shoulson I,Doherty RA

更新日期：1985-02-18 00:00:00

abstract：:The role of alpha 1-adrenoceptors in the mediation of autonomic functions, particularly in the control of the cardiovascular system, is widely known. It has been shown that alpha 1-adrenoceptors localized in human prostate mediate the contraction of prostatic smooth muscles which produces an increase in the intraureth...

journal_title：Life sciences

authors： Yamada S,Tanaka C,Kimura R,Kawabe K

更新日期：1994-01-01 00:00:00

abstract：:Brain noradrenaline takes part in the regulation of several brain functions. The formation of brain noradrenaline depends on brain tyrosine (Tyr) levels, which associates with the ratio in plasma of Tyr to other large, neutral amino acids (LNAA). Tyr metabolism has been studied in users of the new generation combined ...

journal_title：Life sciences

authors： Møller SE,Maach-Møller B,Olesen M,Madsen B,Madsen P,Fjalland B

更新日期：1995-01-01 00:00:00